Protein Alignment Nlg1 and CEL

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 160/567 - (28%)
• Similarity: 249/567 - (43%)
• Gaps: 103/567 - (18%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLP-WQGLKIARHLPPVC 221
            :..:.|.:.|:.::..:...  .||.|.|:|:| |||   :.:....|.| |||...|::....|
Human    26 VYTEGGFVEGVNKKLGLLGD--SVDIFKGIPFA-APT---KALENPQPHPGWQGTLKAKNFKKRC 84

  Fly   222 PQ-KLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVLVYLHG 285
            .| .:...|.:|                      .|||||||::||....| ..:...|:::::|
Human    85 LQATITQDSTYG----------------------DEDCLYLNIWVPQGRKQ-VSRDLPVMIWIYG 126

  Fly   286 ESFEWNSGNP--------YDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAA 342
            .:|...||:.        |||..:::.|.|||||.|||:|.||||... ||:...||.|.||..|
Human   127 GAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTG-DANLPGNYGLRDQHMA 190

  Fly   343 LHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQ 407
            :.|:|.||.|||||.:.:||.|.|.|.|.|:...:||...||..|||..||.|:|.|......|.
Human   191 IAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLF 255

  Fly   408 LTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALT-QFSTSLG------------ 459
            ...::|..:.||:.:...      :..||:       :..|.||| .:...|.
Human   256 WAKKVAEKVGCPVGDAAR------MAQCLK-------VTDPRALTLAYKVPLAGLEYPMLHYVGF 307

  Fly   460 -PIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL---ALEEGLRE-NERDNLLR 519
             |::||..||..|..:..:..:    .|.:.| |.:...|..|::   |:.:|.:: .|.|
Human   308 VPVIDGDFIPADPINLYANAAD----IDYIAG-TNNMDGHIFASIDMPAINKGNKKVTEED---- 363

  Fly   520 FY-MQSRFDIRPDLALA-ATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPL-LQTGMFHA 581
            || :.|.|.|...|..| .|...|.:.:.......|  .:..|:|..:|...:.|. :......|
Human   364 FYKLVSEFTITKGLRGAKTTFDVYTESWAQDPSQEN--KKKTVVDFETDVLFLVPTEIALAQHRA 426

  Fly   582 DV-NRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMA 645
            :. :.:.|.|:|.|.|....:.....:...:::.::||.|.|.    |:| |..|::.:|:|::|
Human   427 NAKSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFAT----PTG-YRPQDRTVSKAMIA 486

  Fly   646 YWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNI 692
            |||||.|||:|......  :.:|          |..:......||.|
Human   487 YWTNFAKTGDPNMGDSA--VPTH----------WEPYTTENSGYLEI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	160/567 (28%)
		Aes	<263..>408	CDD:223730	62/152 (41%)
CEL	NP_001798.3	Heparin-binding	21..121		31/123 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910