Protein Alignment Nlg1 and Ces1d

DIOPT Version :9

• Sequence 1: NP_001246966.1
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_444430.2
• Gene: Ces1d / 104158
• MGIID: 2148202
• Length: 565
• Species: Mus musculus
• Alignment Length: 600
• Identity: 170/600 - (28%)
• Similarity: 272/600 - (45%)
• Gaps: 94/600 - (15%)

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQ-VDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVC 221
            :...:|:::|   ::....|..| |..|||:|:|:.|.|:.||.||....||..:|.....||:|
Mouse    26 VNTVKGKVLG---KYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMC 87

  Fly   222 PQK------LPDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYAVL 280
            .|.      |.:|..:..||:.          |.:    ||||||||:|.|.:..:::  :..|:
Mouse    88 SQDAVGGQVLSELFTNRKENIP----------LQF----SEDCLYLNIYTPADLTKNS--RLPVM 136

  Fly   281 VYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHW 345
            |::||........:.|||..||::..|:|||:.||||:.||.... |.|:..|:..|||:|||.|
Mouse   137 VWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFSTG-DEHSRGNWGHLDQVAALRW 200

  Fly   346 IKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTM 410
            :::||..|||:...||:.|.|.|...|:.|::||:|..||||||..||.:::....:.....:..
Mouse   201 VQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAG 265

  Fly   411 QIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTALTQFSTSL--GP---------IVDG 464
            .:|....|      :.....|::.|||.:...::|.....|..|...|  .|         ::||
Mouse   266 LVATLSGC------KTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDG 324

  Fly   465 HVIPNQPYKVMGHYTEHFSRYDLLFGITESE---SYHTLAALALEEGLRENERDNLLRFYMQSRF 526
            .|:|..|.:::..  :.||....:.||.:.|   ...||....|.||..:.:..|.|.:......
Mouse   325 VVLPKAPEEILAE--KSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGKLDQKTANSLLWKSYPTL 387

  Fly   527 DIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYV 591
            .|..:: :....:||....::..|     .:|:..|:::|.....|.:.....|.|.....|||.
Mouse   388 KISENM-IPVVAEKYLGGTDDLTK-----KKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYE 446

  Fly   592 FGHN----SATGPFAHL-PHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAYWTNFV 651
            |.:.    ||..|.|.: .|   |:|:..:||:|....|.      :.:|..||:.||.:|.||.
Mouse   447 FEYRPSFVSAMRPKAVIGDH---GDEIFSVFGSPFLKDGA------SEEETNLSKMVMKFWANFA 502

  Fly   652 KTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPD 716
            :.|||         |...|.      .|||:::: :.||.||.......:.:...::|| .||
Mouse   503 RNGNP---------NGGGLP------HWPEYDQK-EGYLKIGASTQAAQRLKDKEVSFW-AEL-- 548

  Fly   717 ELNQIAAIQEQLQKP 731
                  ..:|..|:|
Mouse   549 ------RAKESAQRP 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	163/577 (28%)
		Aes	<263..>408	CDD:223730	54/144 (38%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	163/577 (28%)
		Aes	<121..>239	CDD:223730	46/120 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810