Protein Alignment Nlg1 and Ces2

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001177298.1
• Gene: Ces2 / 100910144
• RGDID: 6504334
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 186/617 - (30%)
• Similarity: 283/617 - (45%)
• Gaps: 106/617 - (17%)

  Fly   129 EGSSEHEPSTTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAP 193
            :.|.|..|..|.|..:   |..||.:.::  .|.|                 |..|||:|:|:.|
  Rat    27 QDSPESSPIRTTHTGQ---VQGKLDHVKD--TKAG-----------------VHTFLGIPFAKPP 69

  Fly   194 TGNRRFMPPGAPLPWQGLKIARHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLPYLRTESEDC 258
            .|..||.||..|.||.|::.|...|.:|.|.|..|...|..:|...    ||.:     :.||||
  Rat    70 VGPLRFAPPEPPEPWSGVRDATSQPAMCLQNLDILDEVGLLDMKMI----LSSI-----SMSEDC 125

  Fly   259 LYLNLYVP-H-EEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGF 321
            ||||:|.| | .|..:.|    |:|::||.:......:.||||:|:...:::|||:.||||||||
  Rat   126 LYLNVYAPAHAREGSNLP----VMVWIHGGALVVGMASMYDGSLLTVNEDLVVVTIQYRLGVLGF 186

  Fly   322 LRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFH 386
            .... |.|...|:..|||:|||.|:::||..|||:.:|||:.|.|.|...|:..::||::.||||
  Rat   187 FSTG-DEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQGLFH 250

  Fly   387 RAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDILHIPTAL 451
            .||:.||.|:.....|..|..::..:|....|      ||.|.:.|:.|||.:...:||    .:
  Rat   251 GAIMESGVALLPDLISETSETVSTTVAKLSGC------EAMDSEALVRCLRAKSGAEIL----VI 305

  Fly   452 TQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL-AALALEEGLRENERD 515
            .:....:..:|||..:|..|.:::.  :|.|.....:.|:...|...|: ..:...:.::|..|:
  Rat   306 NKVFKMIPAVVDGEFLPRHPKELLA--SEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRE 368

  Fly   516 NLLRFYMQ--SRFDIRP---DLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQ 575
            ||......  ::..:.|   ||.:...:....|.....|:.|         :::.|...|.|.||
  Rat   369 NLQAVLKDTAAQMMLPPECGDLLMEEYMGNTDDSQTLQIQYT---------EMMGDFLFVIPALQ 424

  Fly   576 TGMF---HADVNRRNYMYVFGH-----NSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSG-- 630
            ...|   ||.|    |.|.|.|     .:...|.....|:   :|:.|:||:       |.||
  Rat   425 VAHFQRSHAPV----YFYEFQHAPSYFKNVRPPHVKADHA---DEVPFVFGS-------FFSGMK 475

  Fly   631 -NYTVQEKLLSEAVMAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGI 694
             ::|.:|:|||..:|.||.||.:.|||         ||..|.:      ||..:...| ||.:..
  Rat   476 LDFTEEERLLSRRMMKYWANFARQGNP---------NSEGLPY------WPALDHDEQ-YLQLDT 524

  Fly   695 PPTVGYKYRQIYMNFWNKELPDELNQIAAIQE 726
            .|.|....:...:.||.|.||.::.::...|:
  Rat   525 HPAVDRALKARRLQFWTKTLPQKIEELNGAQK 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	172/571 (30%)
Ces2	NP_001177298.1	COesterase	32..540	CDD:395084	178/594 (30%)