DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and nlgn3

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_012823589.1	Gene:	nlgn3 / 100329188	XenbaseID:	XB-GENE-977261	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	239/782 - (30%)
Similarity:	362/782 - (46%)	Gaps:	140/782 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 YTQEIQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLP 218
            |:|.:....|:|.| ||....:..|..|||:||:|||..|.|.:||:||..|..|.|::.|.|..
Frog    34 YSQTVNTHYGKLRG-TRVPLPSEILGPVDQYLGVPYAAPPVGEKRFLPPEPPPSWSGIRNATHFS 97

  Fly   219 PVCPQKL----PDLSPHGSENMSRARHKHLSRLLPYLRTESEDCLYLNLYVPHEEPQSTPKQYA- 278
            |||||.:    ||:.      |......:|..:..||:.:||||||||:|||.|:.:...|:..
Frog    98 PVCPQNIQNAVPDIM------MPVWFTSNLDTVTGYLQEQSEDCLYLNIYVPTEDVKRISKECVR 156

  Fly   279 ---------------------------------------VLVYLHGESFEWNSGNPYDGSVLSSY 304
                                                   |:||:||.|:...|||..|||||:||
Frog   157 KPNKKICRKGGPSAKKQGEELSDNDEDEEGDIRDTGAKPVMVYIHGGSYMEGSGNMIDGSVLASY 221

  Fly   305 GEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGA 369
            |.|:|:|:|||:||||||.....|.. .||.|||||.||.|:.||:..||||..|:|:.|...||
Frog   222 GNVVVITLNYRVGVLGFLSTGDQAAK-GNYGLLDQIQALRWVSENVAFFGGDPHRITVFGSGIGA 285

  Fly   370 ACVNYLMVSPVASGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLD 434
            :||:.|.:|..:.|||.|||:.||||:|.||.:.|.::.|..:|..:.|.:.:.|:      ::|
Frog   286 SCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTRLLAEKVGCNVLDTVD------MVD 344

  Fly   435 CLRHRRYQDILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHT 499
            |||.:..::::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|....
Frog   345 CLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQ--GEFLNYDIMLGVNQGEGLKF 407

  Fly   500 LA-ALALEEGLR--------ENERDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE 555
            :. .:..|:|:.        .|..|||.. |.:.:..:|..:..         ||.:.....|.|
Frog   408 VENVVDAEDGVSGSDFDYSVSNFVDNLYG-YPEGKDTLRETIKF---------MYTDWADRDNPE 462

  Fly   556 -HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGHN--SATGP-FAHLPHSIMGEELAFI 616
             .|..::.:.:|.:.|.|.:.|...||......|.|.|.|:  |...| :|...|   |:|:.::
Frog   463 TRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWADAAH---GDEVPYV 524

  Fly   617 FGAPLAAAGP---FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPK--APWKGIFINSHALEWDRYD 676
            ||.|:  .||   ||. |::..:.:||..||.|||||.|||:|.  .|....||::.|..::  :
Frog   525 FGVPM--VGPTDLFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFE--E 584

  Fly   677 LDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNFWNKELPDELNQIAAIQEQLQKPGQEVITGHMS 741
            :.|.::|.|.|.||:||:.|.|...||...:.||...:|...|    :.:...      .|...:
Frog   585 VAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYN----LHDMFH------YTSTTT 639

  Fly   742 KYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTF-GHVHKMQGGSDFEDL 805
            |..|.|......:      .:.|.:....:.|.|            ||| |.|.|.....|..|.
Frog   640 KVPPSDTTQNSHI------TRRPKVWDTKRPGVS------------PTFNGPVAKWDPELDPVDP 686

  Fly   806 VTSTNSLESGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPA 870
            |.    ::...|:           ...:.:.||:...::.||:|.:.....|..:||......|:
Frog   687 VV----IQDPRDY-----------STELSVTIAVGASLLFLNVLAFAALYYRNDKRRQDTQRQPS 736

  Fly   871 PK 872
            |:
Frog   737 PQ 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	208/617 (34%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	74/184 (40%)
nlgn3	XP_012823589.1	COesterase	31..618	CDD:278561	208/617 (34%)
nlgn3	XP_012823589.1	Aes	<195..>302	CDD:223730	57/107 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020