DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg1 and nlgn4xb

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	NP_001159809.1	Gene:	nlgn4xb / 100147967	ZFINID:	ZDB-GENE-100309-1	Length:	795	Species:	Danio rerio

Alignment Length:	764	Identity:	237/764 - (31%)
Similarity:	350/764 - (45%)	Gaps:	149/764 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 QYTQEIQV--KQGRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIA 214
            |.||.|.|  ..|:|.|:  |..:.|. |..|:||||:|||.||||.|||..|..||.|.|::.|
Zfish    18 QQTQFITVTTNYGKLRGL--RVALPSEILGPVEQFLGVPYAMAPTGERRFQAPEPPLSWPGIRNA 80

  Fly   215 RHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLP------------YLRTESEDCLYLNLYVP- 266
            ....|||||.|.|             ...|:.:||            |:..:||||||||:|||
Zfish    81 TQFAPVCPQFLED-------------RLLLTDMLPVWFTANLDTVATYVHDQSEDCLYLNIYVPT 132

  Fly   267 HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNI 331
            .||.|.......|:||:||.|:...:||..|||||:|||.||||||||||||||||.....|..
Zfish   133 EEETQDDAGLKPVMVYIHGGSYVEGTGNMIDGSVLASYGNVIVVTVNYRLGVLGFLSTGDQAAK- 196

  Fly   332 ANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAM 396
            .||.|||||.||.|:||||::|.||..|||:.|...||:||:.|.:|..:..||.:||:.||:|:
Zfish   197 GNYGLLDQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHSGTAL 261

  Fly   397 SDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDV-LLDCLRHRRYQDILHIPTALTQFSTSLGP 460
            |.||.:.|..:.|..:|..:.|       .|||.: |::||:.:.|::::.......::..:.||
Zfish   262 SSWAVNYQPAKYTRLLAEKVGC-------NEDDTLELIECLQSKNYKELIEQNITPAKYHIAFGP 319

  Fly   461 IVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL-AALALEEGLRENERD-------NL 517
            ::||.|||:.|..:|..  ..|..||::.|:.:.|.|..: ..|..|:.:..|:.:       :.
Zfish   320 VIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGYKFVDGILDSEDRVTSNDFEFAISEFVDH 382

  Fly   518 LRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHA 581
            |..|.:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.:.|...||
Zfish   383 LYGYPEGKDTLRETIKF---------MYTDWADRENPEMRRKTLVALFTDHQWVAPAVATADLHA 438

  Fly   582 DVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAY 646
            ......|.|.|.|:..:........|..|:||.::||.|:.......:.|::..:.:||..||.|
Zfish   439 QYGSPTYFYAFYHHCQSDMKPAWADSSHGDELPYVFGIPMIGPTDLFNCNFSKNDIMLSAVVMTY 503

  Fly   647 WTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYM 707
            ||||.|||:|..|    .|.|....:..|    ::.|.::|.:.|.||:||:.|.|...||...:
Zfish   504 WTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWSKYNPKDQLYLHIGLKPRVRDHYRATKI 564

  Fly   708 NFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQS 772
            .||.:.:|...|    |.|..|      .....:|..|:|
Zfish   565 AFWLELVPHLHN----INELFQ------YVSSTTKIPPQD------------------------- 594

  Fly   773 GESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPP----------ETVA 827
                        ..|  |.:..::           |.....|...||.|||          :|..
Zfish   595 ------------TTP--FSYTKRL-----------SNKLFPSTTRHPPAPPANTKQMSDQQKTSE 634

  Fly   828 KSEAT-----------MQLLIALITIIIVLNLLIYGTFLLRQRRRRAKA 865
            .::.|           :.:.||:...::.||:|.:.....::.:.|.::
Zfish   635 HADGTVIIEARDYSTELSVTIAVGASLLFLNILAFAALYYKKDKHRLES 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	210/586 (36%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	77/145 (53%)
nlgn4xb	NP_001159809.1	COesterase	17..567	CDD:278561	210/586 (36%)
nlgn4xb	NP_001159809.1	Aes	70..>243	CDD:223730	89/186 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920