Protein Alignment Nlg1 and nlgn4xb

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: NP_001159809.1
• Gene: nlgn4xb / 100147967
• ZFINID: ZDB-GENE-100309-1
• Length: 795
• Species: Danio rerio
• Alignment Length: 764
• Identity: 237/764 - (31%)
• Similarity: 350/764 - (45%)
• Gaps: 149/764 - (19%)

  Fly   153 QYTQEIQV--KQGRLMGITRRFQVTSG-LRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIA 214
            |.||.|.|  ..|:|.|:  |..:.|. |..|:||||:|||.||||.|||..|..||.|.|::.|
Zfish    18 QQTQFITVTTNYGKLRGL--RVALPSEILGPVEQFLGVPYAMAPTGERRFQAPEPPLSWPGIRNA 80

  Fly   215 RHLPPVCPQKLPDLSPHGSENMSRARHKHLSRLLP------------YLRTESEDCLYLNLYVP- 266
            ....|||||.|.|             ...|:.:||            |:..:||||||||:|||
Zfish    81 TQFAPVCPQFLED-------------RLLLTDMLPVWFTANLDTVATYVHDQSEDCLYLNIYVPT 132

  Fly   267 HEEPQSTPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNI 331
            .||.|.......|:||:||.|:...:||..|||||:|||.||||||||||||||||.....|..
Zfish   133 EEETQDDAGLKPVMVYIHGGSYVEGTGNMIDGSVLASYGNVIVVTVNYRLGVLGFLSTGDQAAK- 196

  Fly   332 ANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAM 396
            .||.|||||.||.|:||||::|.||..|||:.|...||:||:.|.:|..:..||.:||:.||:|:
Zfish   197 GNYGLLDQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHSGTAL 261

  Fly   397 SDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDV-LLDCLRHRRYQDILHIPTALTQFSTSLGP 460
            |.||.:.|..:.|..:|..:.|       .|||.: |::||:.:.|::::.......::..:.||
Zfish   262 SSWAVNYQPAKYTRLLAEKVGC-------NEDDTLELIECLQSKNYKELIEQNITPAKYHIAFGP 319

  Fly   461 IVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTL-AALALEEGLRENERD-------NL 517
            ::||.|||:.|..:|..  ..|..||::.|:.:.|.|..: ..|..|:.:..|:.:       :.
Zfish   320 VIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGYKFVDGILDSEDRVTSNDFEFAISEFVDH 382

  Fly   518 LRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHA 581
            |..|.:.:..:|..:..         ||.:.....|.| .|..::.:.:|.:.|.|.:.|...||
Zfish   383 LYGYPEGKDTLRETIKF---------MYTDWADRENPEMRRKTLVALFTDHQWVAPAVATADLHA 438

  Fly   582 DVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAY 646
            ......|.|.|.|:..:........|..|:||.::||.|:.......:.|::..:.:||..||.|
Zfish   439 QYGSPTYFYAFYHHCQSDMKPAWADSSHGDELPYVFGIPMIGPTDLFNCNFSKNDIMLSAVVMTY 503

  Fly   647 WTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYM 707
            ||||.|||:|..|    .|.|....:..|    ::.|.::|.:.|.||:||:.|.|...||...:
Zfish   504 WTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWSKYNPKDQLYLHIGLKPRVRDHYRATKI 564

  Fly   708 NFWNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQS 772
            .||.:.:|...|    |.|..|      .....:|..|:|
Zfish   565 AFWLELVPHLHN----INELFQ------YVSSTTKIPPQD------------------------- 594

  Fly   773 GESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPP----------ETVA 827
                        ..|  |.:..::           |.....|...||.|||          :|..
Zfish   595 ------------TTP--FSYTKRL-----------SNKLFPSTTRHPPAPPANTKQMSDQQKTSE 634

  Fly   828 KSEAT-----------MQLLIALITIIIVLNLLIYGTFLLRQRRRRAKA 865
            .::.|           :.:.||:...::.||:|.:.....::.:.|.::
Zfish   635 HADGTVIIEARDYSTELSVTIAVGASLLFLNILAFAALYYKKDKHRLES 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	207/582 (36%)
nlgn4xb	NP_001159809.1	COesterase	24..567	CDD:395084	206/580 (36%)