DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and Nlgn4l

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_036018038.1	Gene:	Nlgn4l / 100113365	MGIID:	3775191	Length:	945	Species:	Mus musculus

Alignment Length:	812	Identity:	238/812 - (29%)
Similarity:	348/812 - (42%)	Gaps:	142/812 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222
            :....|:|.|: |.......|..|.||||:|||..|||.|||.||..|..|.|::.|....||||
Mouse    31 VATNYGKLRGV-RAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCP 94

  Fly   223 QKLPDLSPHGSENMSRAR-----HKHLSRLLPYLRTESEDCLYLNLYVP---------------- 266
            |.|.:.:      :.|.|     ..:|..:..|::.:||||||||||||
Mouse    95 QHLDERA------LLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGGANGKKMADDVTGND 153

  Fly   267 HEEPQ-----------STPKQYAVLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLG 320
            |.:.|           :...:..|:||:||.|:...:.|..|||||:|||:||||||||||||||
Mouse   154 HGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLGVLG 218

  Fly   321 FLRPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLF 385
            ||.....|.. .||.|||||.||.|::||..|||||..|||:.|...||:||:.|.:|..:.|||
Mouse   219 FLSTGDQAAK-GNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVSLLTLSHYSEGLF 282

  Fly   386 HRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNE------HVEAEDDDVLLDCLRHRRYQDI 444
            .:||:.||:|:|.||.:.|..:....:...:.|...:      .....|...|:.|||.:...::
Mouse   283 QKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWDSASLVSCLRGKAAGEL 347

  Fly   445 LHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAAL------ 503
            .........:..:.||.|||.|||:.|..:|..  ..|..||::.|:.:.|....:..|
Mouse   348 ARARVTPATYHVAFGPTVDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGARFVDGLGGGHDG 410

  Fly   504 ------------ALEEGLRENERDNLLRFYMQSRFDI-----------RPD---LALAATLKKYQ 542
                        ..::.:::...|..........||:           ||:   .||..|:|
Mouse   411 GYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPEGRGDALRETVK--- 472

  Fly   543 DMYNNPIKATNLE-HRDVVLDILSDARVVGPLLQTGMFHADVNRRNYMYVFGH------------ 594
            .||.:.....:.| .|..::.:.:|.:.|.|.:.|...||......|.|.|.|
Mouse   473 FMYTDWADRDSPEARRKTLVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHRCHGGGGGGGGV 537

  Fly   595 -------------NSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAVMAY 646
                         ..|...:|...|   |:|:.::||.|:|..|.....|::..:.:||..||.|
Mouse   538 DGVAGGVAGGVGGEEARPAWADAAH---GDEVPYVFGVPMAGPGDVFGCNFSRNDVMLSAVVMTY 599

  Fly   647 WTNFVKTGNPKAP--WKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPTVGYKYRQIYMNF 709
            ||||.|||:|..|  ....|:::....::  ::.|.:::.|.|.||:||:.|.|...||...:.|
Mouse   600 WTNFAKTGDPNQPVAQDTRFVHTRPNRFE--EVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAF 662

  Fly   710 WNKELPDELNQIAAIQEQLQKPGQEVITGHMSKYGPRDHGAEDPVRTLKLLLQEPSLAGPTQSGE 774
            | .||...|:.:||      .||     .::|....|...:.||.|       :|...|   .|.
Mouse   663 W-LELVPHLHGLAA------DPG-----AYLSAAATRAAPSGDPDR-------DPGGGG---GGR 705

  Fly   775 STETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLESGEDHPQAPPETVAKSEATMQLLIAL 839
            .....|...    |.......|..||.......|..:..||........||.......:.:.||:
Mouse   706 RRPRPATRR----PAVMTSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAV 766

  Fly   840 ITIIIVLNLLIYGTFLLRQRRRRAKALPFPAP 871
            ...::.||:|.:.....::.:||.:....|.|
Mouse   767 GASLLFLNVLAFAALYYKKDKRRHETHRRPPP 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	202/649 (31%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	77/171 (45%)
Nlgn4l	XP_036018038.1	COesterase	30..663	CDD:395084	202/649 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010