Protein Alignment Nlg1 and nlgn1

DIOPT Version :10

• Sequence 1: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Sequence 2: XP_017213657.1
• Gene: nlgn1 / 100002610
• ZFINID: ZDB-GENE-090918-1
• Length: 867
• Species: Danio rerio
• Alignment Length: 1017
• Identity: 275/1017 - (27%)
• Similarity: 401/1017 - (39%)
• Gaps: 311/1017 - (30%)

  Fly   123 AVLATDEGSSEHEP--STTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFL 185
            |.||..|...|.:|  :||:                      |::.|..:... ...|..|.|||
Zfish    41 AQLAASEKLDETDPIVTTTY----------------------GKVRGFKKELN-NEILGPVIQFL 82

  Fly   186 GLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQ-----KLPDLSPHGSENMSRARHKHLS 245
            |:|||..|||.|||.||..|:.|..::.|....|||||     :|||:
Zfish    83 GVPYAAPPTGERRFQPPEPPISWSEIRNATQFAPVCPQTLLEGRLPDV----------------- 130

  Fly   246 RLLP------------YLRTESEDCLYLNLYVPHEEPQSTPKQYA-------------------- 278
             :||            |::.:|||||:||:|||.|:.:...|:.|
Zfish   131 -MLPVWFTNSIEVVSSYVQDQSEDCLFLNIYVPTEDVKRISKECARKPGKKICRKGGPLSKKQND 194

  Fly   279 ---------------------VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFL 322
                                 |:|::||.|:...:||.:|||:|:|||.|||:||||||||||||
Zfish   195 DLADNDGAEDEDIRESGSPKPVMVFVHGGSYMEGTGNMFDGSILASYGNVIVITVNYRLGVLGFL 259

  Fly   323 RPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVA------ 381
            .....|.. .||.|||.|.||.|..|||..||||..|:|:.|...||:|||.|.:|..:
Zfish   260 STGDQAAK-GNYGLLDLIQALRWTSENIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWS 323

  Fly   382 ---SGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQD 443
               .|||.|||..||:|:|.||.|.|..:....:|..:.|.|.:.||      :::||:.:.|::
Zfish   324 NSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLAKKVGCNLKDTVE------MVECLQKKHYKE 382

  Fly   444 ILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEE 507
            ::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|....:..:. .|.
Zfish   383 LVEQDIQPARYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGLKFVELIVDNEN 445

  Fly   508 GLRENERDNLLRFYMQSRF------DIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILS 565
            |::.|:.|..:..::...:      ||     |..|:|   .||.:.....|.| .|..:|.:.:
Zfish   446 GVQANDFDYAVSSFVDDLYGYPEGKDI-----LRETIK---FMYTDWADRHNPETRRKTLLALFT 502

  Fly   566 DARVVGPLLQTGMFHADVNRRNYMYVFGHNSAT---GPFAHLPHSIMGEELAFIFGAPLAAAGP- 626
            |.:.|.|.:.|...|:......|.|.|.|:..|   .|:|...|   |:|:.::||.|:  .||
Zfish   503 DHQWVAPAVATADLHSSFGSPTYFYAFYHHCQTEQVPPWADAAH---GDEIPYVFGLPM--IGPT 562

  Fly   627 --FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRR 685
              ||. |::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.|..:|::
Zfish   563 ELFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWTRYNQK 622

  Fly   686 AQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQKPGQEVITGHMSKYGPRDH 748
            .|.||:||:.|.|...||...:|.|.:.:|  ..||:::.|....:.|..||......|.
Zfish   623 DQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHSLNEVSQIISTTKLPPPEVTPRTPKKI----- 682

  Fly   749 GAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLE 813
                ||.|.:          |..:...|||...:..|....|                     |.
Zfish   683 ----PVNTKR----------PYPTPFPTETQDSHNQNQNQPF---------------------LV 712

  Fly   814 SGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTIL 878
            ...|:           ...:.:.||:...::.||:|.:.....::.:||
Zfish   713 DQRDY-----------STELSVTIAVGASLLFLNILAFAALYYKKDKRR---------------- 750

  Fly   879 SYDGANDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVDTHTKVCEWMSSQ--- 940
                  .|..:|||..|                     |....|      .||:..|.||.|
Zfish   751 ------HEVHRRCSPQR---------------------TTANEL------PHTQEEEIMSLQMKH 782

  Fly   941 --------EA--PKSGSFNTATPP---------PQPILSDGRLIICQDIEVADAALLIPQHM--- 983
                    ||  |......||.||         |..|          .:...:...:||..|
Zfish   783 SDLERECREAMHPHEVVLRTACPPDYTLAMRRSPDDI----------PLMTPNTITMIPNSMPGL 837

  Fly   984 ---HEPQHYEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHS 1022
               |....|.   ..|::.|..|             |.||||
Zfish   838 TSLHPFNSYS---SGQNNTLPHP-------------HPHSHS 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	205/637 (32%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:395084	208/661 (31%)