DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg1 and nlgn1

DIOPT Version :9

Sequence 1:	NP_001246966.1	Gene:	Nlg1 / 40913	FlyBaseID:	FBgn0051146	Length:	1354	Species:	Drosophila melanogaster
Sequence 2:	XP_017213657.1	Gene:	nlgn1 / 100002610	ZFINID:	ZDB-GENE-090918-1	Length:	867	Species:	Danio rerio

Alignment Length:	1017	Identity:	275/1017 - (27%)
Similarity:	401/1017 - (39%)	Gaps:	311/1017 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 AVLATDEGSSEHEP--STTHHPERRHVVPDKLQYTQEIQVKQGRLMGITRRFQVTSGLRQVDQFL 185
            |.||..|...|.:|  :||:                      |::.|..:... ...|..|.|||
Zfish    41 AQLAASEKLDETDPIVTTTY----------------------GKVRGFKKELN-NEILGPVIQFL 82

  Fly   186 GLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCPQ-----KLPDLSPHGSENMSRARHKHLS 245
            |:|||..|||.|||.||..|:.|..::.|....|||||     :|||:
Zfish    83 GVPYAAPPTGERRFQPPEPPISWSEIRNATQFAPVCPQTLLEGRLPDV----------------- 130

  Fly   246 RLLP------------YLRTESEDCLYLNLYVPHEEPQSTPKQYA-------------------- 278
             :||            |::.:|||||:||:|||.|:.:...|:.|
Zfish   131 -MLPVWFTNSIEVVSSYVQDQSEDCLFLNIYVPTEDVKRISKECARKPGKKICRKGGPLSKKQND 194

  Fly   279 ---------------------VLVYLHGESFEWNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFL 322
                                 |:|::||.|:...:||.:|||:|:|||.|||:||||||||||||
Zfish   195 DLADNDGAEDEDIRESGSPKPVMVFVHGGSYMEGTGNMFDGSILASYGNVIVITVNYRLGVLGFL 259

  Fly   323 RPSIDAHNIANYALLDQIAALHWIKENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVA------ 381
            .....|.. .||.|||.|.||.|..|||..||||..|:|:.|...||:|||.|.:|..:
Zfish   260 STGDQAAK-GNYGLLDLIQALRWTSENIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWS 323

  Fly   382 ---SGLFHRAILMSGSAMSDWAASNQSLQLTMQIAHALECPLNEHVEAEDDDVLLDCLRHRRYQD 443
               .|||.|||..||:|:|.||.|.|..:....:|..:.|.|.:.||      :::||:.:.|::
Zfish   324 NSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLAKKVGCNLKDTVE------MVECLQKKHYKE 382

  Fly   444 ILHIPTALTQFSTSLGPIVDGHVIPNQPYKVMGHYTEHFSRYDLLFGITESESYHTLAALA-LEE 507
            ::.......::..:.||::||.|||:.|..:|..  ..|..||::.|:.:.|....:..:. .|.
Zfish   383 LVEQDIQPARYHIAFGPVIDGDVIPDDPQILMEQ--GEFLNYDIMLGVNQGEGLKFVELIVDNEN 445

  Fly   508 GLRENERDNLLRFYMQSRF------DIRPDLALAATLKKYQDMYNNPIKATNLE-HRDVVLDILS 565
            |::.|:.|..:..::...:      ||     |..|:|   .||.:.....|.| .|..:|.:.:
Zfish   446 GVQANDFDYAVSSFVDDLYGYPEGKDI-----LRETIK---FMYTDWADRHNPETRRKTLLALFT 502

  Fly   566 DARVVGPLLQTGMFHADVNRRNYMYVFGHNSAT---GPFAHLPHSIMGEELAFIFGAPLAAAGP- 626
            |.:.|.|.:.|...|:......|.|.|.|:..|   .|:|...|   |:|:.::||.|:  .||
Zfish   503 DHQWVAPAVATADLHSSFGSPTYFYAFYHHCQTEQVPPWADAAH---GDEIPYVFGLPM--IGPT 562

  Fly   627 --FPSGNYTVQEKLLSEAVMAYWTNFVKTGNPKAP----WKGIFINSHALEWDRYDLDWPEFNRR 685
              ||. |::..:.:||..||.|||||.|||:|..|    .|.|....:..|    ::.|..:|::
Zfish   563 ELFPC-NFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE----EVAWTRYNQK 622

  Fly   686 AQAYLNIGIPPTVGYKYRQIYMNFWNKELP--DELNQIAAIQEQLQKPGQEVITGHMSKYGPRDH 748
            .|.||:||:.|.|...||...:|.|.:.:|  ..||:::.|....:.|..||......|.
Zfish   623 DQLYLHIGLKPRVKEHYRANKVNLWLELVPHLHSLNEVSQIISTTKLPPPEVTPRTPKKI----- 682

  Fly   749 GAEDPVRTLKLLLQEPSLAGPTQSGESTETAAENMYNAPPTFGHVHKMQGGSDFEDLVTSTNSLE 813
                ||.|.:          |..:...|||...:..|....|                     |.
Zfish   683 ----PVNTKR----------PYPTPFPTETQDSHNQNQNQPF---------------------LV 712

  Fly   814 SGEDHPQAPPETVAKSEATMQLLIALITIIIVLNLLIYGTFLLRQRRRRAKALPFPAPKLGGTIL 878
            ...|:           ...:.:.||:...::.||:|.:.....::.:||
Zfish   713 DQRDY-----------STELSVTIAVGASLLFLNILAFAALYYKKDKRR---------------- 750

  Fly   879 SYDGANDEELKRCSKSRDGDDSFVLEMTRKSNTYEAIKTGQRSLSCSTVDTHTKVCEWMSSQ--- 940
                  .|..:|||..|                     |....|      .||:..|.||.|
Zfish   751 ------HEVHRRCSPQR---------------------TTANEL------PHTQEEEIMSLQMKH 782

  Fly   941 --------EA--PKSGSFNTATPP---------PQPILSDGRLIICQDIEVADAALLIPQHM--- 983
                    ||  |......||.||         |..|          .:...:...:||..|
Zfish   783 SDLERECREAMHPHEVVLRTACPPDYTLAMRRSPDDI----------PLMTPNTITMIPNSMPGL 837

  Fly   984 ---HEPQHYEMLLQRQHSALTEPSDEILQQQYPLRNHSHSHS 1022
               |....|.   ..|::.|..|             |.||||
Zfish   838 TSLHPFNSYS---SGQNNTLPHP-------------HPHSHS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg1	NP_001246966.1	COesterase	153..710	CDD:278561	205/641 (32%)
Nlg1	NP_001246966.1	Aes	<263..>408	CDD:223730	76/194 (39%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:306613	208/661 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.780