DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg3 and CES2

DIOPT Version :9

Sequence 1:NP_001036685.2 Gene:Nlg3 / 40912 FlyBaseID:FBgn0083963 Length:1159 Species:Drosophila melanogaster
Sequence 2:NP_001352334.1 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:658 Identity:178/658 - (27%)
Similarity:281/658 - (42%) Gaps:145/658 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            :|.|..|..|.:.|.:|.:.|.:.. |:.:.|||:|.||:|.|||.||.....||||:.......
Human    30 ASPIRTTHTGQVLGSLVHVKGANAG-VQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPA 93

  Fly   219 VCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283
            :|.|.|..:.:|.          |.......| ..:.|||||||:||.|            :.|.
Human    94 MCLQDLTAVESEF----------LSQFNMTFP-SDSMSEDCLYLSIYTP------------AHSH 135

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348
            .||:                            .||:|::||.:..:...:.||||:||:...::|
Human   136 EGSN----------------------------LPVMVWIHGGALVFGMASLYDGSMLAALENVVV 172

  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413
            |.|.||||||||.:.. |:::  ..|:|.:|.:|||.|:::|||.|||:|:.:|:.|...|...|
Human   173 VIIQYRLGVLGFFSTG-DKHA--TGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSV 234

  Fly   414 HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKT 478
            ..|:.| .:.:| ||:.||:.||..|.| .|:::.|...:.|..:::....:....|:.|||.|:
Human   235 SSLVVS-PISQG-LFHGAIMESGVALLP-GLIASSADVISTVVANLSACDQVDSEALVGCLRGKS 296

  Fly   479 LDQLLSV--PIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIA 541
            .:::|::  |.:          .|.|||  .|.::|..|....|.|..|...:.......|.   
Human   297 KEEILAINKPFK----------MIPGVV--DGVFLPRHPQELLASADFQPVPSIVGVNNNEF--- 346

  Fly   542 AAGGWGTPGQLENIVLMRKTAINKLSR-YDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAY 605
               ||..|               |:.| ||...                    |.||.:.  :|.
Human   347 ---GWLIP---------------KVMRIYDTQK--------------------EMDREAS--QAA 371

  Fly   606 VRNTYT-FHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNS 669
            ::...| ..|...|..::.|  ::......|..::.:..|.::|:..|.||.|.... .......
Human   372 LQKMLTLLMLPPTFGDLLRE--EYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHF-QCSRAPV 433

  Fly   670 YLYVFDYQTRF--GDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNF 732
            |.|.|.:|..:  ...|......||::||::|.:...|.:..|    |:.|..||..:|.||:||
Human   434 YFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKF----TEEEEQLSRKMMKYWANF 494

  Fly   733 VRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIP- 796
            .|.||||.: ...|             |..::. .::||..:.:|.:....:||||.||...:| 
Human   495 ARNGNPNGE-GLPH-------------WPLFDQ-EEQYLQLNLQPAVGRALKAHRLQFWKKALPQ 544

  Fly   797 ---DLHKP 801
               :|.:|
Human   545 KIQELEEP 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg3NP_001036685.2 COesterase 151..791 CDD:278561 173/642 (27%)
Aes <313..>410 CDD:223730 39/96 (41%)
CES2NP_001352334.1 COesterase 30..538 CDD:306613 173/642 (27%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142568
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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