DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg3 and CES2

DIOPT Version :10

Sequence 1:NP_731170.2 Gene:Nlg3 / 40912 FlyBaseID:FBgn0083963 Length:1159 Species:Drosophila melanogaster
Sequence 2:NP_003860.3 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:658 Identity:178/658 - (27%)
Similarity:281/658 - (42%) Gaps:145/658 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            :|.|..|..|.:.|.:|.:.|.:.. |:.:.|||:|.||:|.|||.||.....||||:.......
Human    30 ASPIRTTHTGQVLGSLVHVKGANAG-VQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPA 93

  Fly   219 VCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283
            :|.|.|..:.:|.          |.......| ..:.|||||||:||.|            :.|.
Human    94 MCLQDLTAVESEF----------LSQFNMTFP-SDSMSEDCLYLSIYTP------------AHSH 135

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348
            .||:                            .||:|::||.:..:...:.||||:||:...::|
Human   136 EGSN----------------------------LPVMVWIHGGALVFGMASLYDGSMLAALENVVV 172

  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413
            |.|.||||||||.:.. |:::  ..|:|.:|.:|||.|:::|||.|||:|:.:|:.|...|...|
Human   173 VIIQYRLGVLGFFSTG-DKHA--TGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSV 234

  Fly   414 HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKT 478
            ..|:.| .:.:| ||:.||:.||..|.| .|:::.|...:.|..:::....:....|:.|||.|:
Human   235 SSLVVS-PISQG-LFHGAIMESGVALLP-GLIASSADVISTVVANLSACDQVDSEALVGCLRGKS 296

  Fly   479 LDQLLSV--PIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIA 541
            .:::|::  |.:          .|.|||  .|.::|..|....|.|..|...:.......|.   
Human   297 KEEILAINKPFK----------MIPGVV--DGVFLPRHPQELLASADFQPVPSIVGVNNNEF--- 346

  Fly   542 AAGGWGTPGQLENIVLMRKTAINKLSR-YDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAY 605
               ||..|               |:.| ||...                    |.||.:.  :|.
Human   347 ---GWLIP---------------KVMRIYDTQK--------------------EMDREAS--QAA 371

  Fly   606 VRNTYT-FHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNS 669
            ::...| ..|...|..::.|  ::......|..::.:..|.::|:..|.||.|.... .......
Human   372 LQKMLTLLMLPPTFGDLLRE--EYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHF-QCSRAPV 433

  Fly   670 YLYVFDYQTRF--GDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNF 732
            |.|.|.:|..:  ...|......||::||::|.:...|.:..|    |:.|..||..:|.||:||
Human   434 YFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKF----TEEEEQLSRKMMKYWANF 494

  Fly   733 VRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIP- 796
            .|.||||.: ...|             |..::. .::||..:.:|.:....:||||.||...:| 
Human   495 ARNGNPNGE-GLPH-------------WPLFDQ-EEQYLQLNLQPAVGRALKAHRLQFWKKALPQ 544

  Fly   797 ---DLHKP 801
               :|.:|
Human   545 KIQELEEP 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg3NP_731170.2 COesterase 154..791 CDD:395084 173/642 (27%)
CES2NP_003860.3 COesterase 30..538 CDD:395084 173/642 (27%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.

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