Protein Alignment Nlg3 and Ache

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: XP_038945765.1
• Gene: Ache / 83817
• RGDID: 69313
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 674
• Identity: 192/674 - (28%)
• Similarity: 289/674 - (42%)
• Gaps: 157/674 - (23%)

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::..|.|.:.|:.::..|   .||.|:.|||:|.||||:.|||||.....|||:..|..|..||.
  Rat    40 LVRVRGGQLRGIRLKAPG---GPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCY 101

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGS 286
            |.:..::......|.....|            ..||||||||::.|.   .|.:|.:
  Rat   102 QYVDTLYPGFEGTEMWNPNR------------ELSEDCLYLNVWTPY---PRPTSPT-------- 143

  Fly   287 SSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSG----NPYDGSVLASYGQIL 347
                                          |||::::|..:  .||    :.|||..||.....:
  Rat   144 ------------------------------PVLIWIYGGGF--YSGASSLDVYDGRFLAQVEGTV 176

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            :|::|||:|..|||.....|  ..|.|.||:|...||.|::||||||||||.|:||.|...|||.
  Rat   177 LVSMNYRVGTFGFLALPGSR--DAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAAS 239

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVS--NPAKYAAIVAHHVNC------ASDLPHAH 469
            |...|  :::|...||:||:|.||:...||:.||  ...:.|.::|..|.|      .:|   ..
  Rat   240 VGMHI--LSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGND---TE 299

  Fly   470 LMKCLREKTLDQLLSVP--IRPPE--FGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAA 530
            |:.|||.:....|:...  :.|.|  |.|:|.|.:|      ||::...|       :|..:|..
  Rat   300 LISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVD------GDFLSDTP-------EALINTGD 351

  Fly   531 GNGLGGEAGIAAAGG-----WGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQ 590
            ...|....|:....|     :|.||       ..|...:.:||...:||              |:
  Rat   352 FQDLQVLVGVVKDEGSYFLVYGVPG-------FSKDNESLISRAQFLAG--------------VR 395

  Fly   591 YGIEADRRSRILKAYVRNTYTFHLNEIFA-TIVNEYTDWERPVQHPINIRDETLEALSDAQVVAP 654
            .|:.                  ..:::.| .:|..||||..| :.|.::||.....:.|..||.|
  Rat   396 IGVP------------------QASDLAAEAVVLHYTDWLHP-EDPAHLRDAMSAVVGDHNVVCP 441

  Fly   655 AAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEI 719
            .||.....:|.....|.|:|:::.....:|...|..||.::.:|||.||....     |||..|.
  Rat   442 VAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSL-----NYTVEER 501

  Fly   720 SLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKP-KLKNHY 783
            ..::.:|.||:||.|||:||:..::           |:..|..|.:..::|::.:.|| :::...
  Rat   502 IFAQRLMKYWTNFARTGDPNDPRDS-----------KSPRWPPYTTAAQQYVSLNLKPLEVRRGL 555

  Fly   784 RAHRLSFWLNLIPDLHKPGGDNVP 807
            ||...:||...:|.|.......||
  Rat   556 RAQTCAFWNRFLPKLLSATATEVP 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	186/656 (28%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	186/656 (28%)