DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and TG

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	817	Identity:	196/817 - (23%)
Similarity:	299/817 - (36%)	Gaps:	273/817 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SSSATS--SSVPSLSLT--SSSSAGL-----SSPGS-----SSSSSSSSTSTSGSNSNRSSRPTS 133
            |::|||  |:|..|.|:  |...|.|     :.||:     .:.:.|.:.|..|.|.....|..:
Human  2116 STAATSNFSAVRDLCLSECSQHEACLITTLQTQPGAVRCMFYADTQSCTHSLQGQNCRLLLREEA 2180

  Fly   134 NN-----SNSNSNYSPNHDQLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPV 193
            .:     ..|..:|..:...:|.....|::. |:.||.      .|.....|:.:.|:|||:||:
Human  2181 THIYRKPGISLLSYEASVPSVPISTHGRLLG-RSQAIQ------VGTSWKQVDQFLGVPYAAPPL 2238

  Fly   194 GNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSED 258
            ...||..| ....|:|...|.:....|.|  |.....|:                    ...|||
Human  2239 AERRFQAP-EPLNWTGSWDASKPRASCWQ--PGTRTSTS--------------------PGVSED 2280

  Fly   259 CLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVH 323
            |||||:::|..|....|                                          ||||.|
Human  2281 CLYLNVFIPQNVAPNAS------------------------------------------VLVFFH 2303

  Fly   324 G-----ESYEWNSGNPYDGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAA 383
            .     ||..|.:   .|||.||:.|.::|||.:||:||.|||::.:...|   .|:||:|.:||
Human  2304 NTMDREESEGWPA---IDGSFLAAVGNLIVVTASYRVGVFGFLSSGSGEVS---GNWGLLDQVAA 2362

  Fly   384 LHWLKENIAAFGGDPNSITLAGHGTGA--ACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVS 446
            |.|::.:|..|||||..::||....||  |.:|.|  :.......||.||:||.||.|:|.:::|
Human  2363 LTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLL--TARATNSQLFRRAVLMGGSALSPAAVIS 2425

  Fly   447 NP-AKYAAI-VAHHVNCASDLPHAHLMKCLREKTLD-------QLLSV--PIRPPEFGFAFGPSI 500
            :. |:..|| :|..|:|... ....::.|||:|..:       :||:|  |..      .:||.|
Human  2426 HERAQQQAIALAKEVSCPMS-SSQEVVSCLRQKPANVLNDAQTKLLAVSGPFH------YWGPVI 2483

  Fly   501 DGVVIDGGDYVPPAP--------------GSP-------AAQAQAQASTAAG------------- 531
            ||..:    ..|||.              ||.       .|:|..|...:.|
Human  2484 DGHFL----REPPARALKRSLWVEVDLLIGSSQDDGLINRAKAVKQFEESRGRTSSKTAFYQALQ 2544

  Fly   532 NGLGGE---AGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGI 593
            |.||||   |.:.||..|                                           .|.:
Human  2545 NSLGGEDSDARVEAAATW-------------------------------------------YYSL 2566

  Fly   594 EADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQT 658
            |..                         .::|..:.|.:::          |..|..::.|   .
Human  2567 EHS-------------------------TDDYASFSRALEN----------ATRDYFIICP---I 2593

  Fly   659 VDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGE-----DLPYIFGAPLVGGFNHFTRNYTKTE 718
            :|:.||..:.:...||.|..     |:..|  ||.     |:.:..|.|.   :..:...::..|
Human  2594 IDMASAWAKRARGNVFMYHA-----PENYG--HGSLELLADVQFALGLPF---YPAYEGQFSLEE 2648

  Fly   719 ISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAY--ESVHKKYLNFDTKPKLKN 781
            .|||..:|.|:|:|:|:||||...|.   ||:..: :.| .|..:  .:..:.|..|......:.
Human  2649 KSLSLKIMQYFSHFIRSGNPNYPYEF---SRKVPT-FAT-PWPDFVPRAGGENYKEFSELLPNRQ 2708

  Fly   782 HYRAHRLSFWLNLIPDLH-----KPGGDNVPAAHHQL 813
            ..:....|||...|..|.     ..||.:..:...:|
Human  2709 GLKKADCSFWSKYISSLKTSADGAKGGQSAESEEEEL 2745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	168/701 (24%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	41/101 (41%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129		6/12 (50%)
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187		11/56 (20%)
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		178/745 (24%)
		COesterase	2197..2718	CDD:395084	169/707 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768		3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910