DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and NLGN2

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	943	Identity:	301/943 - (31%)
Similarity:	438/943 - (46%)	Gaps:	212/943 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::||..|.:.||..:|:...|.||..:.|:|||:||:|..||.||.:.|.|.||:.|....|.||
Human    43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACP 107

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGS 286
            |.|   |....|: .:|....:.|:....|:|||||||||||:|||.:
Human   108 QNL---HGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTE----------------- 151

  Fly   287 SSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTI 351
                .|..:.....::.:........|.|.||::|:||.||...:||.:||||||:||.::|.|:
Human   152 ----DGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATL 212

  Fly   352 NYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFL 416
            ||||||||||:.. |:.:|  .||||:|.|.||.||.||||.|||||..||:.|.|.||:||:.|
Human   213 NYRLGVLGFLSTG-DQAAK--GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLL 274

  Fly   417 ISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLDQ 481
            |.|.. .|| ||.:||..||:.::.||:...|.||..::|..|.|..: ..|..::|||.|...:
Human   275 ILSHH-SEG-LFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDRE-DSAEAVECLRRKPSRE 336

  Fly   482 LLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGGW 546
            |:...::|..:..||||.:|      ||.||..|.
Human   337 LVDQDVQPARYHIAFGPVVD------GDVVPDDPE------------------------------ 365

  Fly   547 GTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQYGIEADRRSRILKAYVRNTY 610
                     :||::   .:...||::.||.:.|.. |..:|.:.:.|:.|......:..:|.|.|
Human   366 ---------ILMQQ---GEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLY 418

  Fly   611 TFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLHSADHRNS 669
            .:.     |.|   ||...||||..  :....:|.:||.|| :|.|.||||..|..|| ||:::.
Human   419 GYPEGKDVLRE---TIKFMYTDWAD--RDNGEMRRKTLLALFTDHQWVAPAVATAKLH-ADYQSP 477

  Fly   670 -YLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFV 733
             |.|.|.:..:....|:.....||::|||:||.|:||..:.|..|::|.::.||.|||.||:||.
Human   478 VYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFA 542

  Fly   734 RTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNL 794
            :||:||:.:..:    |   .:.:|::.:.|:.:.|..|:||:...||:::::|||::::|||.|
Human   543 KTGDPNQPVPQDTKFIH---TKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLEL 604

  Fly   795 IPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQVFSL 859
            :|.||.        .|.:|.   .....:|..|:..|..||     |.|.....
Human   605 VPHLHN--------LHTELF---TTTTRLPPYATRWPPRPP-----AGAPGTRR----------- 642

  Fly   860 LNLSSPSSSLQRNGTRYGGGKIYPDDMMDGDHAGGAASASQDSDGFAAYSTALSVTIAIGCSLLI 924
               ..|.::|........|.:.|  |...||        |:|      |||.||||:|:|.|||.
Human   643 ---PPPPATLPPEPEPEPGPRAY--DRFPGD--------SRD------YSTELSVTVAVGASLLF 688

  Fly   925 LNVLIFAGVYYQRDK------TRLSEPRPQTKLKRQENGQMPNNICG--------------DLET 969
            ||:|.||.:||:||:      .|||.|           |...:.:.|              :.|.
Human   689 LNILAFAALYYKRDRRQELRCRRLSPP-----------GGSGSGVPGGGPLLPAAGRELPPEEEL 742

  Fly   970 LTIHAK------SDPATILSHHHAMQHHQLPPPEFA--------DIPHRA------------PPP 1008
            :::..|      :|||..|        ....||::.        |:|..|            |||
Human   743 VSLQLKRGGGVGADPAEAL--------RPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPP 799

  Fly  1009 PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPHA 1041
            |....||. |.|..........|....:|.||:
Human   800 PPPPPSLH-PFGPFPPPPPTATSHNNTLPHPHS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	226/645 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	56/96 (58%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	226/645 (35%)
		Aes	<170..>268	CDD:223730	56/100 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668		12/65 (18%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835		12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69317
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.870