Protein Alignment Nlg3 and NLGN4X

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 288/916 - (31%)
• Similarity: 422/916 - (46%)
• Gaps: 216/916 - (23%)

  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKA 213
            :.:|....::||..|.|.|:...|....|.|||.|.|:||||||.|..||.||...:.|:|::..
Human    39 IDSQAQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNT 103

  Fly   214 DRFSPVCPQRLPD---IHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDS 275
            .:|:.||||.|.:   :|      :.:|......|..|:.|:|:|:|||||||||||.:
Human   104 TQFAAVCPQHLDERSLLH------DMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTE------ 156

  Fly   276 SGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVL 340
            .|:::..:|...:|...|........:           :|.||:|::||.||...:||..|||:|
Human   157 DGANTKKNADDITSNDRGEDEDIHDQN-----------SKKPVMVYIHGGSYMEGTGNMIDGSIL 210

  Fly   341 ASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAG 405
            ||||.::|:|||||||:||||:.. |:.:|  .||||:|.|.||.|::||:.||||||..:|:.|
Human   211 ASYGNVIVITINYRLGILGFLSTG-DQAAK--GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFG 272

  Fly   406 HGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHL 470
            .|.||:||..|..| ...|| ||.:||:.||:.|:.|::...||||..|:|..|.| :.|....:
Human   273 SGAGASCVSLLTLS-HYSEG-LFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGC-NMLDTTDM 334

  Fly   471 MKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG 535
            ::|||.|...:|:...|.|..:..||||.|||.||         |..|.
Human   335 VECLRNKNYKELIQQTITPATYHIAFGPVIDGDVI---------PDDPQ---------------- 374

  Fly   536 GEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIEADRR 598
                                :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:..:..
Human   375 --------------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVDGIVDNEDGVTPNDF 415

  Fly   599 SRILKAYVRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAP 654
            ...:..:|.|.|.:     .|.|   ||...||||   |.|     ..|.:||.|| :|.|.|||
Human   416 DFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADKENP-----ETRRKTLVALFTDHQWVAP 472

  Fly   655 AAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEI 719
            |..|.|||:.....:|.|.|.:..:....|......||:::||:||.|::|....|:.|::|.::
Human   473 AVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDV 537

  Fly   720 SLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLK 780
            .||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||:::
Human   538 MLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWSKYNPKDQLYLHIGLKPRVR 599

  Fly   781 NHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAA 845
            :||||.:::|||.|:|.||.
Human   600 DHYRATKVAFWLELVPHLHN--------------------------------------------- 619

  Fly   846 MANFTIFTNQVFSLLNLSS----PSSSLQRNGTRYGGGKIYPDDMMDG------------DHAGG 894
                   .|::|..::.::    |..:....|||....||:|......            .|..|
Human   620 -------LNEIFQYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTG 677

  Fly   895 AASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLS---EPRPQTKLKRQEN 956
            ....:...:....|||.||||||:|.|||.||:|.||.:||::||.|..   .|.||
Human   678 PEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRRPSPQ-------- 734

  Fly   957 GQMPNNICGDL------ETLTIHAKSDPATILSHHH---AMQHHQ----LPPPEFA--------D 1000
                .|...|:      |.:::..|.     |.|.|   ::|.|.    ..||::.        |
Human   735 ----RNTTNDIAHIQNEEIMSLQMKQ-----LEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDD 790

  Fly  1001 IPHRAP 1006
            ||...|
Human   791 IPLMTP 796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	228/654 (35%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	228/654 (35%)