DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg3 and nlgn3a

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_005157256.1	Gene:	nlgn3a / 562702	ZFINID:	ZDB-GENE-071219-1	Length:	878	Species:	Danio rerio

Alignment Length:	885	Identity:	287/885 - (32%)
Similarity:	417/885 - (47%)	Gaps:	169/885 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQ 222
            :||:.|.:.|..|.|....|.||:.|.|:|||:||||..||:||...:.|||:|.|..|:|||||
Zfish    71 VNTQYGKLRGARVPLHSEILGPVDQYLGVPYATPPVGEKRFLPPEPPSSWSGIKNATHFAPVCPQ 135

  Fly   223 RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS---- 283
               :|||....: .||......|..:...:|:|:|||||||||||.:...|.|...:...:
Zfish   136 ---NIHNAVPEI-MMPIWFTFNLDIVATSIQDQNEDCLYLNIYVPTEDVKRISKECTRKPNKKIC 196

  Fly   284 -AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
             .|.:.|...|...|.:..........:|:.   ||:|::||.||...:||..|||||||||.::
Zfish   197 RKGGTHSKKQGEDLSDNDGDEDEDIRDTGAK---PVMVYIHGGSYMEGTGNMIDGSVLASYGNVI 258

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            |:|:|:|:||||||:.. |:.:|  .||||:|.|.||.|:.|||..||||.|.||:.|.|.||:|
Zfish   259 VITLNFRVGVLGFLSTG-DQAAK--GNYGLLDQIQALRWISENIGYFGGDSNRITVFGSGIGASC 320

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREK 477
            |..|..|.. .|| ||:|||:.|||.|:.|::...|.||..::|..|.| :.|....::.|||:|
Zfish   321 VSLLTLSHH-SEG-LFHRAIIQSGSALSSWAVNYQPVKYTRLLAEKVGC-NVLDTLDMVDCLRKK 382

  Fly   478 TLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAA 542
            :..:|:...|:|..:..||||.|||.||         |..|.
Zfish   383 SARELVEQDIQPARYHVAFGPVIDGDVI---------PDDPE----------------------- 415

  Fly   543 AGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQYGIEADRRSRILKAYV 606
                         :||.:   .:...||:|.||.:.|.. |..|..|.:.|:..:.....:..:|
Zfish   416 -------------ILMEQ---GEFLNYDIMLGVNQGEGLRFVENVVDSEDGVSGNDFDFSVSDFV 464

  Fly   607 RNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLH 662
            .:.|.:     .|.|   ||...||||   :.|     ..|.:||.|| :|.|.|.|:..|.|||
Zfish   465 DSLYGYPEGKDTLRE---TIKFMYTDWADRDNP-----ETRRKTLVALFTDHQWVEPSVVTADLH 521

  Fly   663 SADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMF 727
            :.....:|.|.|.:..:....|......||:::||:||.|::|..:.|..|::|.:|.||.|||.
Zfish   522 ARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGIPMIGPTDLFPCNFSKNDIMLSAVVMT 586

  Fly   728 YWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRL 788
            ||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||::::||||.::
Zfish   587 YWTNFAKTGDPNKPVPQDTKFIH---TKANRFEEVAWSKYNPQDQLYLHIGLKPRVRDHYRATKV 648

  Fly   789 SFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFT 853
            :||.:|:|.|            :.|||                              |.::|..|
Zfish   649 AFWKHLVPHL------------YNLHD------------------------------MFHYTSTT 671

  Fly   854 NQVFSLLNLSSPSSSLQRN-GTRYGGGKIYP-----------------DDMMDGDHAGGAASASQ 900
            .:|       .|..:.|.: .|:...||.:|                 .:..:|:...|......
Zfish   672 TKV-------PPLETTQNSLSTKRPNGKAWPFNTKRPPMSPAYNSESGKEQWNGEEEPGPLVVEN 729

  Fly   901 DSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQMPNNICG 965
            ..|    |||.||||||:|.|||.||||.||.:||::||.| .|..||....|.......|....
Zfish   730 PRD----YSTELSVTIAVGASLLFLNVLAFAALYYRKDKRR-QEQHPQPSPPRATTTNDVNRHAP 789

  Fly   966 DLETLTIHAKSDPATILSHHHAMQHHQLPPPEFADIPHRA 1005
            :.|.:::....      :||.........|...|.:|..|
Zfish   790 EEEIMSLQVNQ------THHECDAGPTGDPLRLASLPDYA 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	230/651 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	51/96 (53%)
nlgn3a	XP_005157256.1	COesterase	69..651	CDD:306613	230/651 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000