DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and si:dkey-30c15.17

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_003200472.2	Gene:	si:dkey-30c15.17 / 561375	ZFINID:	ZDB-GENE-060503-450	Length:	657	Species:	Danio rerio

Alignment Length:	792	Identity:	200/792 - (25%)
Similarity:	304/792 - (38%)	Gaps:	247/792 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LAAGISYSSNSGNLSTSQKSPSSANNGGLVLIGSSSATSSSV----PSLSLTSSSSAGLSSPGSS 110
            :|...::...|.||..|.:...:|::.|||   .|:..|:::    |.:.:|...:|   :...|
Zfish    57 IALDDTFLEESLNLIKSLEFYGNADDTGLV---ESTPDSTNIVHKDPEIDITVHDAA---NKAES 115

  Fly   111 SSSSSSSTSTSGSNSNRSSRPTSNNSNSNSNYSPNHDQLPAQLSSRIINTRNGAISGVIVQLDGR 175
            ..:|.::||:.|......:.|                         ::.|..|.:.|:.
Zfish   116 ILNSLNNTSSDGLEDGSGADP-------------------------VVVTLLGRVRGLT------ 149

  Fly   176 HLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERMPKG 240
             |:....:.|||||.||||:.|:.||...:.|.....|....|.|.|              |..|
Zfish   150 -LEKAHVFYGIPYADPPVGDKRWAPPSPVSPWLYTYNATFPRPACMQ--------------MCAG 199

  Fly   241 RLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSS 305
            .   ..||.|  ...||||||||::||:.|                             :.|...
Zfish   200 E---FSRLCP--PEVSEDCLYLNVFVPVSV-----------------------------NLSLPK 230

  Fly   306 SSAGSGSPAKYPVLVFVHGESYEWNSGNP--YDGSVLASYGQILVVTINYRLGVLGFLNANTDRY 368
            .:|       .||:|::||..:...|.:.  |||..:::|...:||.:.||||..|||....|..
Zfish   231 VTA-------LPVMVWIHGGDFIAGSASKPLYDGRYISNYSNTVVVNMEYRLGAFGFLVTGKDPE 288

  Fly   369 SKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV--HFLISSMAVPEGLLFNRA 431
            |....|||::|..|||||::|||||||||||.:||.|...||..|  |.::.|...    ||..|
Zfish   289 SSAVGNYGILDQQAALHWVQENIAAFGGDPNKVTLFGESAGAQSVSLHLMMQSSET----LFRHA 349

  Fly   432 ILMSGSGLAPWSLVSNPAK--YAAI-----VAHHVNCA-SDLPHAHLMKCLREKTLDQLLSV--- 485
            .:.|    .|:||   |.|  :.|:     .|...||: .|||      |:|..:.:.:|:.
Zfish   350 AIQS----LPFSL---PLKTRWDAMKLGWDFAKLTNCSVFDLP------CMRSLSSEDVLNAQIK 401

  Fly   486 -------PIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAA 543
                   |.|..|....:||.|||.::                 :.|..||           ...
Zfish   402 SGSKIINPFRFLEVFETWGPFIDGQLL-----------------KEQPITA-----------FQK 438

  Fly   544 GGW--------GTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSR 600
            |.|        ||..: |.::.:.:.....:|   ::..|....|.|.      |:.:      :
Zfish   439 GHWQSYKPVILGTTSE-EGVMFVYRNFNKSVS---MLECVLYTAAIFK------QHAL------K 487

  Fly   601 ILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQT----VDL 661
            ||..|:    .|:.|:            :|.|.        ..:.::|.....||.|:    |.:
Zfish   488 ILHKYI----PFYRNQ------------DRRVM--------LSQMVTDYVFSCPARQSARSGVKV 528

  Fly   662 HSADHRNSYLYVFDYQTRFGD------YPQRQGCIHGEDLPYIF-GAPLVGGFNHFTRNYTKTEI 719
            ..|    .::||||:.....:      :.....| ||.:||::| .||    ..:||  :|..|.
Zfish   529 GGA----VWMYVFDHAPSDPNIWAELTFCYNHSC-HGAELPFLFDSAP----STNFT--FTPQER 582

  Fly   720 SLSEVVMFYWSNFVRTGNPNEQMETEHGSRQER----SRYKTI-EWTAYESVHKKYLNFDTKPKL 779
            .|:..:..||..|..||:||.:.|..|..|::|    .||..| .||        .||...:...
Zfish   583 LLANRMACYWGMFAHTGDPNSRDEQTHFCREQRLPVWPRYTDIGGWT--------ILNLTLQSHP 639

  Fly   780 KNHYRAHRLSFW 791
            ::..|.|...||
Zfish   640 QHGSRDHFCDFW 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	178/685 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	44/98 (45%)
si:dkey-30c15.17	XP_003200472.2	COesterase	134..651	CDD:306613	179/707 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000