DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg3 and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	904	Identity:	297/904 - (32%)
Similarity:	423/904 - (46%)	Gaps:	197/904 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            |:.|..|.:.|:...|....|.|||.|.|||||.||.|..||.||.....|.|::.|.:|:||||
Zfish    44 IVTTNYGKLRGLKTPLPNEILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCP 108

  Fly   222 QRLPD--IHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQ-VGSRDSSGSSSSSS 283
            |.|.|  :.|     :.:|......|..::.|:|:|||||||||||||.: ||         ::.
Zfish   109 QFLEDRFLLN-----DMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVG---------ANK 159

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348
            ....::..||.:......:           ...||:|::||.||...:||..|||:|||||.::|
Zfish   160 GDDFTNNEGGENKDIHDEN-----------GLRPVMVYIHGGSYMEGTGNMIDGSILASYGNVIV 213

  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413
            ||:||||||||||:.. |:.:|  .||||:|.|.||.|:||||.||.|||..:|:.|.|.||:||
Zfish   214 VTLNYRLGVLGFLSTG-DQAAK--GNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCV 275

  Fly   414 HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKT 478
            ..|..|....:  ||.:||:.||:.|:.|::...||||..|:|..|.| :.|....|::||:.|.
Zfish   276 SLLTLSHYSED--LFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVGC-NMLDSIDLVECLQNKN 337

  Fly   479 LDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAA 543
            ..:|:...|...::..||||.|||.||         |..|.
Zfish   338 YKELIEQYITQAKYHIAFGPVIDGDVI---------PDDPQ------------------------ 369

  Fly   544 GGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIEADRRSRILKAYV 606
                        :||.:   .:...||:|.||.:.|. |.|..|  |.:.|:.|:.....:..:|
Zfish   370 ------------ILMEQ---GEFLNYDIMLGVNQGEG-FKFVDGIVDSEDGVSANDFDFAVSDFV 418

  Fly   607 RNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLH 662
            .:.|.:     .|.|   ||...||||   |.|     ..|.:||.|| :|.|.||||..|.|||
Zfish   419 DHLYGYPEGKDTLRE---TIKFMYTDWADKENP-----ETRRKTLVALFTDHQWVAPAVATADLH 475

  Fly   663 SADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMF 727
            :.....:|.|.|.:..:....|......||:::||:||.|::|..:.|..|::|.::.||.|||.
Zfish   476 AQYGSPTYFYAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVMLSAVVMT 540

  Fly   728 YWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRL 788
            ||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||::::||||.::
Zfish   541 YWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKV 602

  Fly   789 SFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFT 853
            :|||.|:|.||     |:    ::|.........||.. ...|.  ||..|
Zfish   603 AFWLELVPHLH-----NI----NELFQYVSTTTKIPPQ-DTTPF--PYTKR-------------- 641

  Fly   854 NQVFSLLNLSSPSSSLQRNGTRYGG-----GKIYPDDMMDGDHAGGAA---SASQDSDGFAAYST 910
                  |..:.||:      ||:.|     .|...|.....|.:..:|   ...:|      |||
Zfish   642 ------LGKTWPST------TRHPGVPPANTKQTTDQRKGNDLSDDSAVVIETKRD------YST 688

  Fly   911 ALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSE----PRPQTKLKRQENGQMPNNICGDLETLT 971
            .||||||:|.|||.||:|.||.:||::||.|...    |.||       ....|.|:..:...:.
Zfish   689 ELSVTIAVGASLLFLNILAFAALYYKKDKRRHESNRRGPSPQ-------RNSAPANVVANANDIA 746

  Fly   972 IHAKSDPATIL---------SHHH---AMQHHQ----LPPPEFA--------DIPHRAP 1006
             |.:||....|         .|||   ::|.|.    ..|.::.        |||...|
Zfish   747 -HLQSDELMSLQMKQQQMEHEHHHECDSLQAHDTLRLTCPADYTLTLRRSPDDIPLMTP 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	229/651 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	53/96 (55%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	229/651 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860