Protein Alignment Nlg3 and NLGN3

DIOPT Version :9

• Sequence 1: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 916
• Identity: 299/916 - (32%)
• Similarity: 429/916 - (46%)
• Gaps: 178/916 - (19%)

  Fly   148 QLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKK 212
            |.||.    .:||..|.:.|..|.|....|.||:.|.|:|||:||:|..||:||.....|||::.
Human    38 QAPAP----TVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRN 98

  Fly   213 ADRFSPVCPQRLPDIHNETAALERM-PKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSS 276
            |..|.|||||   :||  ||..|.| |......|..:..|:|..:|||||||:|||.:...|.|.
Human    99 ATHFPPVCPQ---NIH--TAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISK 158

  Fly   277 GSSSSSS-----AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYD 336
            ..:...:     .|.|.:...|...:.:..........||:.   ||:|::||.||...:||..|
Human   159 ECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAK---PVMVYIHGGSYMEGTGNMID 220

  Fly   337 GSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSI 401
            ||:|||||.::|:|:|||:||||||:.. |:.:|  .||||:|.|.||.|:.||||.|||||..|
Human   221 GSILASYGNVIVITLNYRVGVLGFLSTG-DQAAK--GNYGLLDQIQALRWVSENIAFFGGDPRRI 282

  Fly   402 TLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLP 466
            |:.|.|.||:||..|..|.. .|| ||.|||:.|||.|:.|::...|.||.:::|..|.| :.|.
Human   283 TVFGSGIGASCVSLLTLSHH-SEG-LFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-NVLD 344

  Fly   467 HAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAG 531
            ...::.|||:|:..:|:...|:|..:..||||.|||.||         |..|.
Human   345 TVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVI---------PDDPE------------ 388

  Fly   532 NGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIE 594
                                    :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:.
Human   389 ------------------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVEGVVDPEDGVS 425

  Fly   595 ADRRSRILKAYVRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQ 650
            .......:..:|.|.|.:     .|.|   ||...||||   :.|     ..|.:||.|| :|.|
Human   426 GTDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADRDNP-----ETRRKTLVALFTDHQ 482

  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYT 715
            .|.|:..|.|||:.....:|.|.|.:..:....|......||:::||:||.|:||..:.|..|::
Human   483 WVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFS 547

  Fly   716 KTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTK 776
            |.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...|
Human   548 KNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIH---TKANRFEEVAWSKYNPRDQLYLHIGLK 609

  Fly   777 PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAA 841
            |::::||||.:::||.:|:|.|            :.|||
Human   610 PRVRDHYRATKVAFWKHLVPHL------------YNLHD-------------------------- 636

  Fly   842 NAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKIYP------DDMMDGDHAGGAASASQ 900
                |.::|..|.:|      ..|.::...:.||...||.:.      ......::|.|:.:..|
Human   637 ----MFHYTSTTTKV------PPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQ 691

  Fly   901 DSDGFAA-----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTR---LSEPRPQTKLKRQENG 957
            |:.....     |||.||||||:|.|||.||||.||.:||::||.|   |.:|.||......|.|
Human   692 DAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELG 756

  Fly   958 QMPNNICGDLETLTIHAKSDPATILSHHHAMQHHQLP--------PPEFADIPHRAPPP----PK 1010
            ..|......|:....|.:.:..   ..|..::...||        .|:  |||...|..    |.
Human   757 AAPEEELAALQLGPTHHECEAG---PPHDTLRLTALPDYTLTLRRSPD--DIPLMTPNTITMIPN 816

  Fly  1011 HMKSLQ 1016
            .:..||
Human   817 SLVGLQ 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	232/660 (35%)
		Aes	<313..>410	CDD:223730	52/96 (54%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	234/663 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694		10/54 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860