DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and ACHE

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	669	Identity:	193/669 - (28%)
Similarity:	291/669 - (43%)	Gaps:	165/669 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::..|.|.:.|:.::..|   .||.|:.|||:|.||:|..||:||.....||||..|..|..||.
Human   107 LVTVRGGRLRGIRLKTPG---GPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCY 168

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGS 286
            |.:..::......|.....|            ..||||||||::.|.   .|.:|.:
Human   169 QYVDTLYPGFEGTEMWNPNR------------ELSEDCLYLNVWTPY---PRPTSPT-------- 210

  Fly   287 SSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSG----NPYDGSVLASYGQIL 347
                                          ||||:::|..:  .||    :.|||..|....:.:
Human   211 ------------------------------PVLVWIYGGGF--YSGASSLDVYDGRFLVQAERTV 243

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            :|::|||:|..|||.....|  :.|.|.||:|...||.|::||:|||||||.|:||.|...|||.
Human   244 LVSMNYRVGAFGFLALPGSR--EAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAAS 306

  Fly   413 V--HFLISSMAVPEGLLFNRAILMSGSGLAPWSLV--SNPAKYAAIVAHHVNC------ASDLPH 467
            |  |.|    :.|...||:||:|.||:...||:.|  ....:.|..:||.|.|      .:|
Human   307 VGMHLL----SPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGND--- 364

  Fly   468 AHLMKCLREKTLDQLLSVP--IRPPE--FGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQAST 528
            ..|:.|||.:....|::..  :.|.|  |.|:|.|.:|      ||::...|         :|..
Human   365 TELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVD------GDFLSDTP---------EALI 414

  Fly   529 AAG--NGLGGEAGIAAAGG-----WGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNS 586
            .||  :||....|:....|     :|.||       ..|...:.:||.:.:||
Human   415 NAGDFHGLQVLVGVVKDEGSYFLVYGAPG-------FSKDNESLISRAEFLAG------------ 460

  Fly   587 GDVQYGIEADRRSRILKAYVRNTYTFHLNEIFA-TIVNEYTDWERPVQHPINIRDETLEALSDAQ 650
              |:.|:.                  .::::.| .:|..||||..| :.|..:|:...:.:.|..
Human   461 --VRVGVP------------------QVSDLAAEAVVLHYTDWLHP-EDPARLREALSDVVGDHN 504

  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYT 715
            ||.|.||.....:|.....|.|||:::.....:|...|..||.::.:|||.||     ..:||||
Human   505 VVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYEIEFIFGIPL-----DPSRNYT 564

  Fly   716 KTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKP-KL 779
            ..|...::.:|.||:||.|||:|||..:.           |..:|..|.:..::|::.|.:| ::
Human   565 AEEKIFAQRLMRYWANFARTGDPNEPRDP-----------KAPQWPPYTAGAQQYVSLDLRPLEV 618

  Fly   780 KNHYRAHRLSFWLNLIPDL 798
            :...||...:||...:|.|
Human   619 RRGLRAQACAFWNRFLPKL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	189/660 (29%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	41/100 (41%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	189/660 (29%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910