DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and alpha-Est1

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_524269.3	Gene:	alpha-Est1 / 40909	FlyBaseID:	FBgn0015568	Length:	565	Species:	Drosophila melanogaster

Alignment Length:	624	Identity:	154/624 - (24%)
Similarity:	234/624 - (37%)	Gaps:	180/624 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 SRIINTRNGAISGVIVQLDGRHLDPVE---AYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRF 216
            ::::.||:|.:.|    ...|.|...|   |:.|||:|.||||.|||..|.....|.||:..
  Fly    32 TKVVCTRDGQVRG----HRRRTLYDEEMYFAFEGIPFAQPPVGELRFRAPQPPHPWLGVRDC--- 89

  Fly   217 SPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSS 281
              ..|:..|                  ..|..:..:...||||||||:|
  Fly    90 --TYPRAKP------------------MQKHFVLSIVEGSEDCLYLNVY---------------- 118

  Fly   282 SSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEW-NSGNPYDGSVLASYGQ 345
                                   |....|..|  .||:|:::|..::: .:|..:..........
  Fly   119 -----------------------SKRLRSDKP--LPVIVWIYGGGFQFGEAGRDFYSPDYFMQQD 158

  Fly   346 ILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGA 410
            ::|||.|||:|.||||:. .||...:|.|.||.|.:.||.|:.:|||.|.|||.:||:.|...||
  Fly   159 VVVVTFNYRVGALGFLSL-ADRDLDVPGNAGLKDQVMALRWISQNIAQFNGDPQNITVMGESAGA 222

  Fly   411 ACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPA-KYAAIVAHHVNCASDLPHAHLMKCL 474
            |.||.|:::... .| ||::||:.|||....|:  :.|: ::|..:|..:..:.......:.:.|
  Fly   223 ASVHALMTTEQT-RG-LFHKAIMQSGSMFCEWA--NEPSGRWAYRLACQLGYSGSENEKEVFRYL 283

  Fly   475 REKTLDQ-------LLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGN 532
            ::....:       |:|...|.....|.|.|.::..:.  .|.|.|       :...:....|
  Fly   284 QKAPASEMAAQGITLVSQEERRQYVLFPFTPVVEPYIT--RDCVLP-------RCHREMLPEA-- 337

  Fly   533 GLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNS--GDVQYGIEA 595
                         ||                |.|   .|:.|....|..||:.|  .|.::.:.|
  Fly   338 -------------WG----------------NDL---PLILGGNSFEGLFSYQSTLHDEEHMLSA 370

  Fly   596 DRRSRILKAYVRNTYT-FHLNEIFATI-VNEYTDWER------------PVQHPIN-IRDETLEA 645
              ...::...:|...| .||.::.... |:.:.|..|            .|:|..: |....|..
  Fly   371 --FEVLIPREIREKSTQSHLKDLLRQFKVDNFDDATRGRMEFNECLHILSVKHFWHGIHRTVLAR 433

  Fly   646 LSDAQVVAPAAQTVDLHSADHRNSYLYVFDYQT-RFGDYPQ------RQGCIHGEDLPYIFGAPL 703
            ||.    |||..|           |||.||..: .|..:.|      .:|..|.:||.|:
  Fly   434 LSH----APATPT-----------YLYRFDVDSPHFNHFRQVMCGKHVRGVSHADDLSYL----- 478

  Fly   704 VGGFNHFTRN---YTKTEISLSEVVMFYWSNFVRTGNPN 739
               |.|...|   .:..|....:.::..|..|.|..|||
  Fly   479 ---FYHILANKVDKSSMEYQTIQRLVGMWVAFARNDNPN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	154/624 (25%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	37/97 (38%)
alpha-Est1	NP_524269.3	COesterase	28..541	CDD:278561	154/624 (25%)
alpha-Est1	NP_524269.3	Aes	<117..>233	CDD:223730	46/157 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440329
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740