DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Ces1b

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	693	Identity:	183/693 - (26%)
Similarity:	280/693 - (40%)	Gaps:	183/693 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 SSRIINTRNGAISGVIVQLDG-RHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFS 217
            ||.:::|..|.|.|....|:| .|  ||..:.|:|:|.||:|:|||.||..|..||.||.|..:.
Mouse    22 SSPVVDTTQGKILGKYTSLEGFEH--PVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNATSYP 84

  Fly   218 PVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSS 282
            |:|.|        .|...::....|...|..:|.|  .||||||||||.|..:
Mouse    85 PMCSQ--------DAVAVQLLSDMLSTKKESIPPL--FSEDCLYLNIYSPADL------------ 127

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
                                |.||        ..||:|::||........:.|:|..|:::..::
Mouse   128 --------------------TKSS--------LLPVMVWIHGGGLMTGGASLYNGLALSAHENVV 164

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            ||||.||||:.|..:.. |.:|:  .|:..:|.:|||.|:::|||.|||:|:|:|:.|...|...
Mouse   165 VVTIQYRLGIWGLFSTG-DEHSR--GNWAHLDQLAALRWVQDNIANFGGNPDSVTVFGSSAGGVS 226

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSN----PAKYAAIVAHHVNCASDLPHAHLMKC 473
            |..|:.|.....  ||:|||  |.|.:...::|..    ....:.::|....| :|.....:::|
Mouse   227 VSVLVLSPLAKN--LFHRAI--SESSVVLENIVITLDLVACDLSQMIATVSGC-NDTSSTAMVQC 286

  Fly   474 LREKTLDQLLSVPIR-----------PPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQAS 527
            ||:||.::||.:.::           ..:...:....|||||:      |.||  ....|:...|
Mouse   287 LRQKTENELLEITVKLEVTKVGGAASAKKDNTSMSTVIDGVVL------PKAP--EEILAEKSFS 343

  Fly   528 TAAGNGLGGEAGIAAAG------GWGTPGQLENIV----LMRKTAINKLSRY--DLMAGVTRAEA 580
            |..          ...|      ||..|..|.:::    :..:||...|.|:  ||
Mouse   344 TVP----------YIVGFNKQEFGWIIPTMLGDLLSEGKMNEETASLLLRRFHSDL--------- 389

  Fly   581 FFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEA 645
                       .|.......:::.|:|.|                       ..|...||..|:.
Mouse   390 -----------NISESLIPAVIEKYLRGT-----------------------DDPAKKRDLLLDM 420

  Fly   646 LSDAQVVAPAAQTVDLHSADHR----NSYLYVFDYQTRF--GDYPQRQGCIHGEDLPYIFGAPLV 704
            .||.....||.    |.|...|    ::|:|.|.|:..|  ...||.....||:::..:||.||:
Mouse   421 FSDVFFGIPAV----LLSRSLRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFSVFGIPLL 481

  Fly   705 GGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKK 769
                  ....::.|.:||::||.:|:||.|.||||.: ...|             |..|:. .:.
Mouse   482 ------KEGTSEEETNLSKMVMKFWANFARNGNPNGE-GLPH-------------WPEYDE-KEG 525

  Fly   770 YLNFDTKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQ 812
            ||......:.....:|..::||..|   |.|...:..|..|.:
Mouse   526 YLQIGATTQQAQRLKAEEVAFWTEL---LAKNPPETDPTEHRE 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	176/670 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	35/96 (36%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	176/670 (26%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	45/162 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740