DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Gli

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	1027	Identity:	249/1027 - (24%)
Similarity:	365/1027 - (35%)	Gaps:	291/1027 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 INTRNGAISGVIVQLDGRHLDPVEAYR-----------------GIPYASPPVGNLRFMPPVSAA 205
            :.|..|.:.|..|.:.. :.||...||                 |||||.||....||.||....
  Fly   137 VTTNYGQVQGFKVYMYD-NPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHR 200

  Fly   206 MWSGVKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQV 270
            .|..::..| |.|.|||.:    ..|.|    .||           :.:..|||||||:|.|
  Fly   201 GWQLLQAVD-FGPACPQPV----RYTGA----TKG-----------IMDMDEDCLYLNVYSP--- 242

  Fly   271 GSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY 335
                                                ..|:|...||||:|::||..:...:.|.:
  Fly   243 ------------------------------------KTGAGVAQKYPVMVYIHGGEFIRGASNLF 271

  Fly   336 DGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNS 400
            .|.:|||:..::|||:|||||.||||:...:   ..|.|||::|...||.|:.:||..|.||.||
  Fly   272 QGHILASFYDVVVVTLNYRLGALGFLSTGDE---NSPGNYGILDQAMALRWVYDNIEFFNGDRNS 333

  Fly   401 ITLAGHGTGAACVHFLISSMAVPEGL-LFNRAILMSGSGLAPWSLVSNPAKYAA-----IVAHHV 459
            |||.|.|.|.|....|   |..|:.. :..|.|..|||.||.|:|:.:  ||.|     ::...:
  Fly   334 ITLFGPGAGGASAGLL---MVAPQTRNIVRRVIAQSGSALADWALIQD--KYRAQNTSRVLGQLL 393

  Fly   460 NCASDLPHAHLMKCLRE-KTLDQLLSVPIRPPEFGFAFGPSID-GVVIDGGDYVPPAPGSPAAQA 522
            .|:.: ....|:.|||. ::..:|.:....|....|.:||.:| ...:.|.|:..
  Fly   394 GCSIE-SSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYE---------- 447

  Fly   523 QAQASTAAGNGLGGEAGIAAAGGW---------GTPGQLENIVLMRKTAINKLSRYDLMAGVTRA 578
                                  ||         .||.     .|:|....|:..:|  |.|||..
  Fly   448 ----------------------GWREKDWRFLTQTPE-----TLIRAGKFNRNIQY--MTGVTTQ 483

  Fly   579 E-AFFSFNSGDVQYGIEADRR---SRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIR 639
            | |||...:..:....|.|.|   .:|.:...|..||.:.|.::..|...||.|..|..:.| ||
  Fly   484 EAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTI-IR 547

  Fly   640 DETLEALSDAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLV 704
            |:.:..|||....||..|.|.|........|:||.:......:.||.:...|..:..::.|||.:
  Fly   548 DQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFM 612

  Fly   705 G-----GFNHFTRN-YTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAY 763
            .     ...|..|| :|..:.::|...|..::||.|.|||..|...  |...:|         ||
  Fly   613 DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVL--GMHFQR---------AY 666

  Fly   764 ESVHKKYLNFDT--KPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSD 826
            :. ..:|||.:|  ...:..:||....:||...:|.:.   |..||              ..|..
  Fly   667 QG-EIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVI---GVLVP--------------TYPPT 713

  Fly   827 ASV--KPLNPPYISRAANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKIYPDDMMDG 889
            ...  :|..|..|:          |...:...|.|:.|......:.||..|. ..:.|.:|:...
  Fly   714 TEYWWEPKEPLQIA----------FWSMSVACFFLIVLVVICCIMWRNAKRQ-SDRFYDEDVFIN 767

  Fly   890 DHAGGAASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPR--PQTKLK 952
               |......||:.|                   :.|..:....:..|.:..:.|.|  |.||
  Fly   768 ---GEGLEPEQDTRG-------------------VDNAHMVTNHHALRSRDNIYEYRDSPSTK-- 808

  Fly   953 RQENGQMPNNICGDLETLTIHAKSDPATILSHHHAMQHHQLPPPEFADIPHRAPPPPKHMKSLQD 1017
                            ||...|.:|..::.|                         |..:...|.
  Fly   809 ----------------TLASKAHTDTTSLRS-------------------------PSSLAMTQK 832

  Fly  1018 PGGGGSVSGAVGVSGVVQMPPPHALQVMGNQCGTLTKKS------CMKQTQAQAQQHSPAQQQQQ 1076
            .....|:...:.:.               ...|.|.|:|      ..:|..:.|:..||..::::
  Fly   833 SSSQASLKSGISLK---------------ETNGHLVKQSERAATPRSQQNGSTAKVASPPVEEKR 882

  Fly  1077 QQQQQQQHVVTHQQHLQNHHNQSMTTVLTTAGGLVVPTPPTVPVIVASTTQH 1128
            ..|......||   .||....:.:.|..:.:|.....||  || ...|||.|
  Fly   883 LLQPLSSTPVT---QLQAEPAKRVPTAASVSGSSRSTTP--VP-SARSTTTH 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	188/678 (28%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	44/96 (46%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	188/678 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850