DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and CG9289

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_609245.1	Gene:	CG9289 / 34195	FlyBaseID:	FBgn0032058	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	187/818 - (22%)
Similarity:	278/818 - (33%)	Gaps:	264/818 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 NSNRSSRPTSNNSNSNSNYSPNHDQLPAQLSSRIINT---RNGAISGVIV-------QLDGRHL- 177
            |:||..:......|.|.....|....|.::..:..|.   :||....|..       :|.||.|
  Fly    28 NANRQKQQKPRPGNQNFGIQKNKRPKPQKVQKQKPNKQQGQNGQEPKVFTTTVPDLGRLRGRTLT 92

  Fly   178 -----DPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERM 237
                 ..:..:..|||....    ||.|...|..|.||..|.|....||.
  Fly    93 TDWTGQKIMQFLDIPYGKAE----RFRPAEPAPSWKGVLPAHRPHAGCPS--------------- 138

  Fly   238 PKGRLEYLKRLLPYLQNQS-----EDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSS 297
                   ::.|:.:.:.:.     ||||.|::              ::.:..|.|
  Fly   139 -------IQDLIVFAKLEEDGFDVEDCLRLSV--------------NTKAMEGKS---------- 172

  Fly   298 SSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDG-SVLASYGQIL-----VVTINYRLG 356
                              .||:|::||:.:       ||| ||.|:.|.:|     :|::.||||
  Fly   173 ------------------LPVMVYIHGDFF-------YDGDSVEAAPGYLLEHDVVLVSVRYRLG 212

  Fly   357 VLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLISSMA 421
            ..|||:..||   ::|.|..:.|||.||.|::::||:|||||..:||.|...|||.|:.|..|.|
  Fly   213 PFGFLSTLTD---EMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPA 274

  Fly   422 VPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLDQLLSVP 486
            ||.| ||:|.|..||:.|:|..:...|......:.....|........|.|||.......||:
  Fly   275 VPAG-LFHRVIYQSGTALSPAFITDAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATMLLA-- 336

  Fly   487 IRPPEFGFAFG------PSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGG 545
                    ||.      ||:.|....|...|                      :||.:||...
  Fly   337 --------AFSVHGENQPSLSGGAYGGVQLV----------------------IGGPSGILPE-- 369

  Fly   546 WGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRNTY 610
              .||:|        .|..|...|..|             .|.|::|                 .
  Fly   370 --HPGRL--------LAAEKFQAYPTM-------------GGSVKHG-----------------G 394

  Fly   611 TFHLNEIFATIVNE-----------YTD--------------WERPVQHPI----NIRDETLEAL 646
            ||.|.:|||.|.||           |.|              |:......|    ::::.|.:.|
  Fly   395 TFMLRDIFADIFNETILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQNDVKNGTFKRL 459

  Fly   647 --------SDAQVVAPAAQTVDLHSADHRNS-YLYVFDYQTRFGDYPQRQGCIHGED----LPYI 698
                    |...:..|....:..::....|| |||.|||:.....|..      |||    :|:.
  Fly   460 TPGLIDLCSTISLKNPVLLVLQANAKKLPNSTYLYSFDYEGEQNRYAT------GEDEANFVPFD 518

  Fly   699 FGAPLVGG------FNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQ-METEHGSRQERSRYK 756
            .|..|...      :..|....:..::.::..::..|::|..||.|... :........|...|.
  Fly   519 MGVSLTDDNLYLFPWPRFLALNSNRDLKVARRMVALWTSFATTGVPQAPGLPAWPAMNDETGPYM 583

  Fly   757 TIEWTAYESVHKKYLNFDTKPKLKNHYR--AHRLSFWLNLIPDLHKPGGDNVPAAH--HQLHDDD 817
            .|:.|.  |....||         :.||  ........||:.|.:....:.:.||.  ..|:|.:
  Fly   584 KIDRTV--SFGDNYL---------DEYRIAVEEAKHGYNLVNDEYYDLQEALLAASKLDSLNDAN 637

  Fly   818 DEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQ 855
            :||.....||..:        |||:.....|:.....:
  Fly   638 EEDEEDQDDAEGQ--------RAASQTGGQNWVFIARK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	165/723 (23%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	41/102 (40%)
CG9289	NP_609245.1	COesterase	83..600	CDD:278561	159/686 (23%)
CG9289	NP_609245.1	Aes	<171..351	CDD:223730	72/228 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830