Protein Alignment Nlg3 and Nlg2

DIOPT Version :9

• Sequence 1: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_001245916.1
• Gene: Nlg2 / 33962
• FlyBaseID: FBgn0031866
• Length: 1248
• Species: Drosophila melanogaster
• Alignment Length: 1218
• Identity: 372/1218 - (30%)
• Similarity: 543/1218 - (44%)
• Gaps: 306/1218 - (25%)

  Fly   111 SSSSSSSTSTSGSNSNRSSR---PTSNNSNSNSNYSPNHDQLPAQL------------------S 154
            |::|::|.:.:|:.|.|...   |      .:|...|.|.:..|.|                  .
  Fly   123 SATSAASAAPAGATSPRRRHLHYP------GHSAVQPGHPEACALLVLLLLTSLWPDCCECLHGG 181

  Fly   155 SRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPV 219
            |..:.|:.|.:.|::|    |....|||:.||||||||||:||||||::.:.|..|:.|||||||
  Fly   182 SNTVKTKYGLLRGIVV----RSSPLVEAFLGIPYASPPVGSLRFMPPITPSTWKTVRSADRFSPV 242

  Fly   220 CPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSA 284
            |||.:|...|...||..:|:.||..|:||||.|:||||||||||||||.:
  Fly   243 CPQNIPIPPNGPEALLEVPRARLAQLRRLLPLLKNQSEDCLYLNIYVPYE--------------- 292

  Fly   285 GSSSSGSGGSSSSSSSSSTSSSSAGSGSP-AKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348
                          :.....::...:|.| .|...:||:|||||:||||||||||.||::|.::|
  Fly   293 --------------TRRQRRNTDDTTGEPKTKLSTVVFIHGESYDWNSGNPYDGSELAAHGNVIV 343

  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413
            ||||:|||:.|||  .|........|:||||::|.|||||||:.||||||.||||.|:||||...
  Fly   344 VTINFRLGIFGFL--KTGGKESAQGNFGLMDLVAGLHWLKENLPAFGGDPQSITLLGYGTGAVLA 406

  Fly   414 HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKT 478
            :.|:.|....:  |..|.:|:|||.|:||::..||......||....|..|:.:..|..|||.|:
  Fly   407 NILVVSPVASD--LIQRTVLVSGSALSPWAIQKNPLFVKRRVAEQTGCHGDMLYDDLAPCLRTKS 469

  Fly   479 LDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAA 543
            :.:||:|.:..|.|...|.|.:||.||           ||.|......:...|:.:...:||..|
  Fly   470 VAELLAVKVDHPRFLVGFAPFVDGTVI-----------SPGANPLGSTTLPLGSAIVSTSGIEYA 523

  Fly   544 GGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRN 608
                                 ...:.||:..:|..|::...::.|:::|....||.|||:.:|||
  Fly   524 ---------------------NFPKRDLIFCLTSVESYLDLSAQDLEFGFNETRRDRILRTFVRN 567

  Fly   609 TYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNSYLYV 673
            .:.:|||||||.:.|||||||:.:::|::.||.||:.|||....:|..:...:||.....:|...
  Fly   568 NFHYHLNEIFAVLKNEYTDWEKAIRNPLSSRDATLQFLSDGHTASPLIKLGYMHSLRGGRAYFLH 632

  Fly   674 FDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTG-- 736
            |.::|...:||||.|.:.|||:|:..|.|:...|.|   |||..|..:..:::.|.|||.:||
  Fly   633 FKHKTIEEEYPQRSGSVRGEDVPFWLGLPMSPLFPH---NYTTQERQIGRLMLRYLSNFAKTGNP 694

  Fly   737 ----------NPNEQMETEHGSRQERS-----------------------------------RYK 756
                      ||||.:||....:::||                                   |.:
  Fly   695 NQSTAKSVLPNPNEVLETALHQQKKRSTSLTHPNLSEALNLAVLYNQRRSNAMHEKRSYIRRRLR 759

  Fly   757 TIE------------------------WTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIPD 797
            :.:                        |.||:.|::.|:....|..:::|||.|:||.||||||.
  Fly   760 SNDAAFTQLGISSERDVGSYDGDELPFWDAYDVVNQLYVELGNKANIQSHYRGHKLSMWLNLIPQ 824

  Fly   798 LHKPGGDNVPA-AHHQLHDDDD------------------EDNNI-----------------PSD 826
            ||:....|..: .|||..||.:                  ||:||                 ||.
  Fly   825 LHRHFNINDQSMRHHQFQDDMNNRDLYEGVVRPQLQTKPAEDDNIIIMQRSRTTTPPPPSKNPST 889

  Fly   827 ASVKPLNP-----PYISRAANAAAMANFTIFTNQ-----------VFSLLNLSSPSSSLQRN--G 873
            .:.:.|||     |..:......||:...:.|.|           |.:..:|::.|:.:..|  .
  Fly   890 NATQALNPLGTGTPTTTECGIDGAMSVSELTTTQSPKDNRTGIVRVETQKDLATASTGIIGNLEL 954

  Fly   874 TRYGGGKIYPDDMMDGDHAGGAASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRD 938
            .|..|||                       .|.:|:|||..|:|:||.|||||||||||:|:||:
  Fly   955 LRRLGGK-----------------------QFQSYTTALIATVAVGCFLLILNVLIFAGIYHQRE 996

  Fly   939 KTRLSEPRPQTKLKRQEN-------------------GQMPNNICGDLETLT---IHAKSDPATI 981
            | |..:.:.:.:|:..:|                   |..|.:| .|..||:   :.:|.....:
  Fly   997 K-RARDAKTKEELQEGDNSKNSSILKLNALMGGGGACGSGPGDI-ADAYTLSGSVVDSKGGVGVV 1059

  Fly   982 LSHHHAMQH--HQLPPPE-FADIPHRAPPPPKHMKSLQDPGGGGSVSGAVGV-----SGVVQMPP 1038
            ...:.....  .||...: ..::|   |.......||.....|...:..:.:     ...::|..
  Fly  1060 FGEYSCYDEKTKQLKEEKLLVELP---PSSSTGQTSLMIDNWGACSTSTLDLLKTKPGDPIEMVT 1121

  Fly  1039 PHAL-QVMGNQCGTLTKKSCMKQTQAQAQQHSPAQQQQQQQQQQQQHVVTHQQHLQ---NHHNQS 1099
            ..|| .||.:.....:|:.....|..|.  :||.|.....|...|......:..::   .|.::
  Fly  1122 YSALPSVMESTSAMSSKRGSFVDTTLQF--NSPQQFDYAVQSSDQMSFKAIEDAVKAAAGHDSE- 1183

  Fly  1100 MTTVLTTAGGLVVPTPPTVPVIVASTTQHQQHQQQHQQQQHQQQQQQQ 1147
                :|....:..|.||....:.|            ||||.|||||||
  Fly  1184 ----ITRDDDIPEPPPPPRSFLAA------------QQQQQQQQQQQQ 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	255/729 (35%)
		Aes	<313..>410	CDD:223730	60/97 (62%)
Nlg2	NP_001245916.1	COesterase	182..712	CDD:278561	236/601 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I889
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I1271
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11301at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6461
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	0	0.000	Not matched by this tool.
	8	8.000