DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and CES4A

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_011521323.1	Gene:	CES4A / 283848	HGNCID:	26741	Length:	628	Species:	Homo sapiens

Alignment Length:	710	Identity:	185/710 - (26%)
Similarity:	291/710 - (40%)	Gaps:	193/710 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHL----DPVEAYRGIPYASPPVGNLRFMPPVSAAMWSG 209
            |.||.:...::|:...:......|.|:.:    .|::.:.|:|::.||:|.|||.||.....|.|
Human    36 LMAQTALGALHTKRPQVVTKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKG 100

  Fly   210 VKKADRFSP-----------------------------VCPQR--------LPDIHNETAALERM 237
            ::.|..:.|                             :.||.        |.:...:.|::...
Human   101 IRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVS 165

  Fly   238 PKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSS 302
            .:.|.::|:        .||||||||:|.|
Human   166 TRERYKWLR--------FSEDCLYLNVYAP----------------------------------- 187

  Fly   303 TSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTINYRLGVLGFL--NANT 365
                :...|.| :.||:|:..|.::...:.:.|:||.||:..::::|.:.:|||:.|||  ...|
Human   188 ----ARAPGDP-QLPVMVWFPGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRT 247

  Fly   366 DRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNR 430
            |. |....|:||:|.:|||.|::||||||||||.::||.|...||..:..|:.| .:..| ||:|
Human   248 DD-SHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMS-PLASG-LFHR 309

  Fly   431 AILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLDQLLSVPIR------- 488
            ||..||:.|....:.|||.|.|..|||...|..:.... |:.|||..:..:::.|..:
Human   310 AISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQI-LVNCLRALSGTKVMRVSNKMRFLQLN 373

  Fly   489 ----PPEFGFAFGPSIDGVVIDGGDYVPPAPGSP-AAQAQAQASTA----AGNGLGGEAGIAAAG 544
                |.|..::..|.:|||||         |..| ....|.:.|:.    ..|.|        ..
Human   374 FQRDPEEIIWSMSPVVDGVVI---------PDDPLVLLTQGKVSSVPYLLGVNNL--------EF 421

  Fly   545 GWGTPGQLE---NIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYV 606
            .|..|..::   |...|||..|.|      |...||           ....|..::...:::.|:
Human   422 NWLLPYIMKFPLNRQAMRKETITK------MLWSTR-----------TLLNITKEQVPLVVEEYL 469

  Fly   607 RNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNSYL 671
            .|             |||: ||:.       :|:..::.:.||..|....||...|.......||
Human   470 DN-------------VNEH-DWKM-------LRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYL 513

  Fly   672 YVFDYQTRFGDY--PQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVR 734
            |.|::..| |..  |:..|..||:::.::||.|...|.:      ...|.:||..:|.||:||.|
Human   514 YEFEHHAR-GIIVKPRTDGADHGDEMYFLFGGPFATGLS------MGKEKALSLQMMKYWANFAR 571

  Fly   735 TGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNL 794
            |||||:      |:.....||...|         |||..|...::....:..:::||::|
Human   572 TGNPND------GNLPCWPRYNKDE---------KYLQLDFTTRVGMKLKEKKMAFWMSL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	181/703 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	41/98 (42%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	179/695 (26%)
CES4A	XP_011521323.1	Aes	<184..>291	CDD:223730	44/147 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810