Protein Alignment Nlg3 and cest-9.2

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_741910.3
• Gene: cest-9.2 / 259729
• WormBaseID: WBGene00007695
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 751
• Identity: 164/751 - (21%)
• Similarity: 256/751 - (34%)
• Gaps: 252/751 - (33%)

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            |.::|.|..|.:.|:....|..:...:  ::.:|:|.||:|.|||.||.....||||..|.::||
 Worm    20 SLKVIETSYGRVRGITEWSDDNNHKYM--FKSVPFAKPPIGKLRFAPPQYPDSWSGVLDASKYSP 82

  Fly   219 VCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283
            .|      :.|.:..  ..|:             ::.||||||:||:
 Worm    83 AC------LSNSSTT--STPQ-------------EHVSEDCLYINIF------------------ 108

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY-DGSVLASY--GQ 345
                               ||.....|    |..|:|:.||.:|..:|...: |..:|..|  ..
 Worm   109 -------------------TSEKCLRS----KCAVIVYFHGGAYNGDSATMFPDNFILERYVAED 150

  Fly   346 ILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGA 410
            :::.....||||.|.|.....  :.|..|..:.|.:.||.::...|..|||||..:|:.||.:|.
 Worm   151 VILAIPGVRLGVFGQLYFGPS--ALLTENLFMFDAVQALDFVHNEIPNFGGDPKQVTIMGHSSGG 213

  Fly   411 ACVHFL-ISSMAVPEGLLFNRAILMSGSGLAPW--SLVSNPAKYAAIVAHHVNC-------ASDL 465
            ..|..| .|:...|:..||.:.|::||:|:..:  .||.|    :.|::..:.|       .:|.
 Worm   214 TLVEALGFSNSVDPDLKLFQQIIVLSGTGMFGFYDLLVDN----SFIISEKLGCFNGTQEERTDA 274

  Fly   466 PHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAA 530
            ..|.:::|:|:                            |||.:.|
 Worm   275 NIAEILECMRQ----------------------------IDGHEIV------------------- 292

  Fly   531 GNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEA 595
                            |....:|::.        ||:...|:.|.    .|...|.     .||.
 Worm   293 ----------------GMQKHMEDVY--------KLTFKSLLRGA----PFMELNG-----KIEK 324

  Fly   596 DRRSRILKAYVRNT--YTFHLNEI--FATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAA 656
            .|.|...:..:..|  |.|. ||:  :..|...:.|:|.||....:..||.::.: |..:...|.
 Worm   325 FRNSTSPRNAIFGTTEYEFR-NEVERYLYITTTFLDFENPVAVAQHFDDELMQNM-DTMINGDAV 387

  Fly   657 Q---TVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTE 718
            .   :....|:...|:...|:.::||...|     ..|..|:.|..|         ..|....|.
 Worm   388 SIFVSAAAFSSAMANAGADVYLFETRQWPY-----SFHVSDMQYFIG---------IHREVLHTH 438

  Fly   719 ISLSEVVMFYWS---NFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNF--DTK-- 776
             .:..:..||..   ||.:||.|:.                  ||.:.|.....||..  ||:
 Worm   439 -DMDILDSFYSKLLVNFTKTGAPSP------------------EWNSLEPEKMNYLELRVDTRNG 484

  Fly   777 --PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLN------ 833
              |.:...|....:|||.          ||.:           |.|.||......|.|.
 Worm   485 KGPVMLEGYHDKEVSFWY----------GDMM-----------DYDRNITKMRQSKGLPRENQGV 528

  Fly   834 -----------PPYISRAANAAAMANFTIFTNQVFS 858
                       .|..:..||.|...|.:..||.:|:
 Worm   529 ESQLKYWSSIVEPRTTAHANNATQENISTSTNVLFT 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	146/665 (22%)
cest-9.2	NP_741910.3	alpha/beta hydrolases	22..501	CDD:473884	145/663 (22%)