Protein Alignment Nlg3 and Nlgn3

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_766520.2
• Gene: Nlgn3 / 245537
• MGIID: 2444609
• Length: 825
• Species: Mus musculus
• Alignment Length: 970
• Identity: 310/970 - (31%)
• Similarity: 442/970 - (45%)
• Gaps: 220/970 - (22%)

  Fly    92 PSLSLTSSSSAGLS---SPGSSSSSSSSSTSTSGSNSNRSSRPTSNNSNSNSNYSPNHDQLPAQL 153
            |||||:.:.:.|.|   :.|..|....:||                             |.||.
Mouse     5 PSLSLSPTPTVGRSLCLTLGFLSLVLRAST-----------------------------QAPAP- 39

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
               .:||..|.:.|..|.|....|.||:.|.|:|||:||:|..||:||.....|||::.|..|.|
Mouse    40 ---TVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPP 101

  Fly   219 VCPQRLPDIHNETAALERM-PKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSS 282
            ||||   :||  ||..|.| |......|..:..|:|..:|||||||:|||    :.|.||:...
Mouse   102 VCPQ---NIH--TAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVP----TEDGSGAKKQ- 156

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
                      |...:.:..........||:.   ||:|::||.||...:||..|||||||||.::
Mouse   157 ----------GEDLADNDGDEDEDIRDSGAK---PVMVYIHGGSYMEGTGNMIDGSVLASYGNVI 208

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            |:|:|||:||||||:.. |:.:|  .||||:|.|.||.|:.||||.|||||..||:.|.|.||:|
Mouse   209 VITLNYRVGVLGFLSTG-DQAAK--GNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASC 270

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREK 477
            |..|..|.. .|| ||.|||:.|||.|:.|::...|.||.:::|..|.| :.|....::.|||:|
Mouse   271 VSLLTLSHH-SEG-LFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC-NVLDTVDMVDCLRQK 332

  Fly   478 TLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAA 542
            :..:|:...|:|..:..||||.|||.||         |..|.
Mouse   333 SAKELVEQDIQPARYHVAFGPVIDGDVI---------PDDPE----------------------- 365

  Fly   543 AGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSG--DVQYGIEADRRSRILKAY 605
                         :||.:   .:...||:|.||.:.|. ..|..|  |.:.|:........:..:
Mouse   366 -------------ILMEQ---GEFLNYDIMLGVNQGEG-LKFVEGVVDPEDGVSGTDFDYSVSNF 413

  Fly   606 VRNTYTF-----HLNEIFATIVNEYTDW---ERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDL 661
            |.|.|.:     .|.|   ||...||||   :.|     ..|.:||.|| :|.|.|.|:..|.||
Mouse   414 VDNLYGYPEGKDTLRE---TIKFMYTDWADRDNP-----ETRRKTLVALFTDHQWVEPSVVTADL 470

  Fly   662 HSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVM 726
            |:.....:|.|.|.:..:....|......||:::||:||.|:||..:.|..|::|.::.||.|||
Mouse   471 HARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVM 535

  Fly   727 FYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHR 787
            .||:||.:||:||:.:..:    |   .:.:|::.:.|:.|....:.||:...||::::||||.:
Mouse   536 TYWTNFAKTGDPNKPVPQDTKFIH---TKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATK 597

  Fly   788 LSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIF 852
            ::||.:|:|.|            :.|||                              |.::|..
Mouse   598 VAFWKHLVPHL------------YNLHD------------------------------MFHYTST 620

  Fly   853 TNQVFSLLNLSSPSSSLQRNGTRYGGGKIYP------DDMMDGDHAGGAASASQDSDGFAA---- 907
            |.:|      ..|.::...:.||...||.:.      ......::|.|:.:..||:.....
Mouse   621 TTKV------PPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPR 679

  Fly   908 -YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTR---LSEPRPQTKLKRQENGQMPNNICGDLE 968
             |||.||||||:|.|||.||||.||.:||::||.|   |.:|.||......|.|..|......|:
Mouse   680 DYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQ 744

  Fly   969 TLTIHAKSDPATILSHHHAMQHHQLP--------PPEFADIPHRAPPP----PKHMKSLQ 1016
            ....|.:.:..   ..|..::...||        .|:  |||...|..    |..:..||
Mouse   745 LGPTHHECEAG---PPHDTLRLTALPDYTLTLRRSPD--DIPLMTPNTITMIPNSLVGLQ 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	231/652 (35%)
Nlgn3	NP_766520.2	COesterase	37..601	CDD:395084	233/656 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		3/31 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..668		8/51 (16%)