DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nlg3 and CES3

DIOPT Version :10

Sequence 1:NP_731170.2 Gene:Nlg3 / 40912 FlyBaseID:FBgn0083963 Length:1159 Species:Drosophila melanogaster
Sequence 2:NP_079198.2 Gene:CES3 / 23491 HGNCID:1865 Length:571 Species:Homo sapiens


Alignment Length:665 Identity:176/665 - (26%)
Similarity:275/665 - (41%) Gaps:174/665 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQ 222
            ::|..|.:.|..|.:.|.. ..|..:.|||:|.||:|..||..|..|..|.||:.|....|:|.|
Human    36 VDTTLGRVRGRQVGVKGTD-RLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQ 99

  Fly   223 RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSS 287
            .:..:::....|    .|:.:        :.:.|||||.||:|.|.:|                 
Human   100 DVESMNSSRFVL----NGKQQ--------IFSVSEDCLVLNVYSPAEV----------------- 135

  Fly   288 SSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTIN 352
                               .||||.    ||:|:|||.:....:...||||.||:||.::|||:.
Human   136 -------------------PAGSGR----PVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQ 177

  Fly   353 YRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLI 417
            ||||||||.:...:.   .|.|.|.:|::|||.|::||||.||||.|.:|:.|...|.:.:..|:
Human   178 YRLGVLGFFSTGDEH---APGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLV 239

  Fly   418 SSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLDQL 482
            .| .|..| ||:|||..||....|..:.|:|...|..:|:.:.|:|..| |.:::||::|..::|
Human   240 LS-PVAAG-LFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSP-AEMVQCLQQKEGEEL 301

  Fly   483 -LSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG---GEAGIAAA 543
             ||..::    ...:..::||.|.         |.||....:.:...:....:|   .|......
Human   302 VLSKKLK----NTIYPLTVDGTVF---------PKSPKELLKEKPFHSVPFLMGVNNHEFSWLIP 353

  Fly   544 GGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRN 608
            .|||....:|           ::||.|::|..|..     ..|.||.                  
Human   354 RGWGLLDTME-----------QMSREDMLAISTPV-----LTSLDVP------------------ 384

  Fly   609 TYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQ-----------TVDL- 661
                  .|:..|:::||                 |.:.||||....|.|           ||.. 
Human   385 ------PEMMPTVIDEY-----------------LGSNSDAQAKCQAFQEFMGDVFINVPTVSFS 426

  Fly   662 -HSADHRNSYLYVFDYQTRFGDY----PQRQGCIHGEDLPYIFGAPLVGGFNHFTR----NYTKT 717
             :..| ..|.::.:::|.|...:    |......||.:..::||.|.:  .:..:|    ..|:.
Human   427 RYLRD-SGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFL--MDESSRLAFPEATEE 488

  Fly   718 EISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTI-EWTAYESVHKKYLNFDTKPKLKN 781
            |..||..:|..|::|.|||:||.               |.: .|..:... ::||..:..|:...
Human   489 EKQLSLTMMAQWTHFARTGDPNS---------------KALPPWPQFNQA-EQYLEINPVPRAGQ 537

  Fly   782 HYRAHRLSFWLNLIP 796
            .:|...:.||...:|
Human   538 KFREAWMQFWSETLP 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg3NP_731170.2 COesterase 154..791 CDD:395084 173/658 (26%)
CES3NP_079198.2 COesterase 32..547 CDD:395084 173/658 (26%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.