Protein Alignment Nlg3 and Ces4a

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 670
• Identity: 175/670 - (26%)
• Similarity: 285/670 - (42%)
• Gaps: 179/670 - (26%)

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|::|.:.|..|.:..   .|::.:.|||::.||||..||.||.....|:|::.|..:.|.|
Mouse    35 LLITKHGILQGKQVHVGD---TPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSC- 95

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAGS 286
              |.:...:..::....:.:.::|        :.||||||||:|.|:
Mouse    96 --LQESWGQILSMYLNTRKQYKWL--------HFSEDCLYLNVYAPV------------------ 132

  Fly   287 SSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILVVTI 351
                                 ...|:|. .||:|:..|.::...|.:.|:||.||:.|::::|.:
Mouse   133 ---------------------LAPGAPL-LPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFL 175

  Fly   352 NYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVH-F 415
            .||||:|||.:...   |....|:||:|.||||.|::|||.||||||:|:||.|...||..|. .
Mouse   176 QYRLGILGFFSTGN---SHARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGL 237

  Fly   416 LISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREKTLD 480
            ::|.:|  :| ||::||..||:.:....:..:|...|..:||...|..:.... :::|||..:.:
Mouse   238 MVSPLA--QG-LFHQAISQSGTAVLKAFITPDPLTSAKKIAHLAGCDHNSTKV-MVECLRSLSAE 298

  Fly   481 QLLSVPIR-----------PPEFGFAFGPSIDGVV--------IDGGDYVPPAP---GSPAAQAQ 523
            ::..|..|           |.|..:...|.:||||        :..|. |.|.|   |...|:.:
Mouse   299 EVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPVVLLTRGQ-VKPVPYLLGVNNAEFE 362

  Fly   524 AQASTAAGNGLGGEAGIAAAGGWGTPGQLE---NIVLMRKTAINKLSRYDLMAGVTRAEAFFSFN 585
                                  |..|..::   |..:|.:|.|||:              .:|||
Mouse   363 ----------------------WNLPFLMKIQLNQRMMNQTNINKI--------------LWSFN 391

  Fly   586 SGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQ 650
               |...|..::...:.:.|:.:..:.|             ||:.       .|:..::.:.||.
Mouse   392 ---VLLNITKEQVPVVAREYLNDAISNH-------------DWKM-------FRNRLIDLIGDAT 433

  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFG----DYPQRQGCIHGEDLPYIFGAPLVGGFNHFT 711
            .|....|....|.......|||.|.:....|    .|   .|..||::|.|:||:|    |:..:
Mouse   434 FVYATLQAARYHRDAGSPVYLYEFKHHASSGIIIKPY---NGADHGDELSYLFGSP----FSKGS 491

  Fly   712 RNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKY--LNFD 774
            ....:.|.||.  :|.||:||..|||||.:              |...|..::. .:||  |:||
Mouse   492 SAGEEKEFSLQ--MMKYWANFAHTGNPNGE--------------KLPYWPRFDK-DEKYLQLDFD 539

  Fly   775 TKPKLKNHYRAHRLSFWLNL 794
            |:..:|  .:..:::||..|
Mouse   540 TRVGVK--LKEKKMAFWSQL 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	172/665 (26%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	172/665 (26%)