DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Ces1f

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	659	Identity:	187/659 - (28%)
Similarity:	279/659 - (42%)	Gaps:	171/659 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            |..:::|.:|.:.|..|.::| ...||..:.|||:|.||:|:|||.||..|..||.||.|..:.|
Mouse    22 SPPVVDTAHGKVLGKHVNVEG-FSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPP 85

  Fly   219 VCPQRLPDIHNETAA----LERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSS 279
            :|.|   |.....|.    ..|..|..||:           ||||||||||.|     .|.|.:|
Mouse    86 MCSQ---DAARGQAVNDLITNRKEKIHLEF-----------SEDCLYLNIYTP-----ADFSKNS 131

  Fly   280 SSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYG 344
                                               :.||:|::||...:....:.:||..|::|.
Mouse   132 -----------------------------------RLPVMVWIHGGGLKLGGASSFDGRALSAYE 161

  Fly   345 QILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTG 409
            .::||.|.|||.:.||.:.. |.:|:  .|:|.:|.:|||||:::|||.|||||.|:|:.|...|
Mouse   162 NVVVVAIQYRLSIWGFFSTG-DEHSR--GNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAG 223

  Fly   410 AACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCL 474
            ...|..||.|.....  ||:|||..||....|.....:.......:|....|.: ...|.::.|:
Mouse   224 GYSVSILILSPLSKN--LFHRAISESGVAFIPGMFTKDVRPITEQIAVTAGCKT-TTSAVIVHCM 285

  Fly   475 REKTLDQLLSVPIRPPEFGFA----------FGPSI-DGVVIDGGDYVPPAPGSPAAQAQAQAST 528
            |:||.::||.:..:...:..:          |..|: ||||:      |..|....|:...
Mouse   286 RQKTEEELLEIMHKLNLYKLSLQGDTKNSDQFVTSVLDGVVL------PKDPKEILAEKNF---- 340

  Fly   529 AAGNGLGGEAGI-AAAGGWGTP---GQL-ENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGD 588
               |.:....|| ....||..|   |.| .::.|.:|.||..|.::..|.|:.
Mouse   341 ---NTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFASMTGIP------------ 390

  Fly   589 VQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVA 653
                                      .:|....|.:||   :....|..||:..|:|:.|.....
Mouse   391 --------------------------EDIIPVAVEKYT---KGSDDPDQIREGVLDAMGDVAFGV 426

  Fly   654 PAAQTVDLHSADHRN----SYLYVFDYQTRFGDYPQRQGCI---HGEDLPYIFGAPLVGGFNHFT 711
            |:.    :.|..||:    :|:|.:.|...|.. |||...:   |.:|:..:||||::      .
Mouse   427 PSV----IVSRGHRDTGAPTYMYEYQYYPSFSS-PQRPKNVVGDHADDVYSVFGAPIL------R 480

  Fly   712 RNYTKTEISLSEVVMFYWSNFVRTGNPN----------EQMETE-H--GSRQERSRYKTIE---W 760
            ...::.||:||::||.:|:||.|.||||          :|.|.. |  |:.|:..|.|..|   |
Mouse   481 EGASEEEINLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEGYLHIGGTTQQAQRLKEEEVTFW 545

  Fly   761 TAYESVHKK 769
            |  :|:.||
Mouse   546 T--QSLAKK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	187/659 (28%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	38/96 (40%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	181/646 (28%)
		Aes	<121..>225	CDD:223730	45/146 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740