DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and NLGN1

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	949	Identity:	298/949 - (31%)
Similarity:	421/949 - (44%)	Gaps:	233/949 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.|.|:..:|:...|.||..:.|:|||:||.|..||.||...:.||.::.|.:|:||||
Human    54 LVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   222 Q-----RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVG-----SRDSS 276
            |     |||::        .:|......|..:..|:|:|||||||||||||.:.|     ..|..
Human   119 QNIIDGRLPEV--------MLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDL 175

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLA 341
            |.:..:.                    ......||.|.  ||:|::||.||...:||.|||||||
Human   176 GDNDGAE--------------------DEDIRDSGGPK--PVMVYIHGGSYMEGTGNLYDGSVLA 218

  Fly   342 SYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGH 406
            |||.::|:|:||||||||||:.. |:.:|  .||||:|:|.||.|..|||..|||||..||:.|.
Human   219 SYGNVIVITVNYRLGVLGFLSTG-DQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS 280

  Fly   407 GTGAACVHFLISSMAVPEGL--------LFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNC-A 462
            |.|.:||:.|..| ...||.        ||.|||..||:.|:.|::...|||||.::|..|.| .
Human   281 GAGGSCVNLLTLS-HYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNV 344

  Fly   463 SDLPHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQAS 527
            ||.  ..|::||::|...:|:...|:|..:..||||.|||.||         |..|.
Human   345 SDT--VELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVI---------PDDPQ-------- 390

  Fly   528 TAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQY 591
                                        :||.:   .:...||:|.||.:.|.. |..|..|...
Human   391 ----------------------------ILMEQ---GEFLNYDIMLGVNQGEGLKFVENIVDSDD 424

  Fly   592 GIEADRRSRILKAYVRNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQ 650
            ||.|......:..:|.|.|.:.     |.|   ||...||||..  :|....|.:||.|| :|.|
Human   425 GISASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWAD--RHNPETRRKTLLALFTDHQ 484

  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYT 715
            .||||..|.||||.....:|.|.|.:..:....|......||:::||:.|.|::|....|..|::
Human   485 WVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFS 549

  Fly   716 KTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTK 776
            |.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.||.|....:.||:...|
Human   550 KNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWTRYSQKDQLYLHIGLK 611

  Fly   777 PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAA 841
            |::|.||||::::.||.|:|.|            |.|:|
Human   612 PRVKEHYRANKVNLWLELVPHL------------HNLND-------------------------- 638

  Fly   842 NAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKI---YPDDMMDGDHAGGAASASQDSD 903
                ::.:|..|.:|        ||:.:....||.....:   :|....|        ...|...
Human   639 ----ISQYTSTTTKV--------PSTDITFRPTRKNSVPVTSAFPTAKQD--------DPKQQPS 683

  Fly   904 GFAA----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQMPNNIC 964
            .|:.    |||.||||||:|.|||.||:|.||.:||::||.|....|.                |
Human   684 PFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRR----------------C 732

  Fly   965 GDLETLT---IHAKSDPATILSHHHAMQHHQLP-------------PPEFA--------DIPHRA 1005
            ....|.|   .||:.:....|...|....|:..             ||::.        |:|...
Human   733 SPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMT 797

  Fly  1006 PPP----PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPH 1040
            |..    |..:..:|......:.:|  |.:..:..|.||
Human   798 PNTITMIPNTIPGIQPLHTFNTFTG--GQNNTLPHPHPH 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	235/663 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	55/96 (57%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	235/663 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I954
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8600
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860