Protein Alignment Nlg3 and NLGN1

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 949
• Identity: 298/949 - (31%)
• Similarity: 421/949 - (44%)
• Gaps: 233/949 - (24%)

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.|.|:..:|:...|.||..:.|:|||:||.|..||.||...:.||.::.|.:|:||||
Human    54 LVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   222 Q-----RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVG-----SRDSS 276
            |     |||::        .:|......|..:..|:|:|||||||||||||.:.|     ..|..
Human   119 QNIIDGRLPEV--------MLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDL 175

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLA 341
            |.:..:.                    ......||.|.  ||:|::||.||...:||.|||||||
Human   176 GDNDGAE--------------------DEDIRDSGGPK--PVMVYIHGGSYMEGTGNLYDGSVLA 218

  Fly   342 SYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGH 406
            |||.::|:|:||||||||||:.. |:.:|  .||||:|:|.||.|..|||..|||||..||:.|.
Human   219 SYGNVIVITVNYRLGVLGFLSTG-DQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS 280

  Fly   407 GTGAACVHFLISSMAVPEGL--------LFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNC-A 462
            |.|.:||:.|..| ...||.        ||.|||..||:.|:.|::...|||||.::|..|.| .
Human   281 GAGGSCVNLLTLS-HYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNV 344

  Fly   463 SDLPHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQAS 527
            ||.  ..|::||::|...:|:...|:|..:..||||.|||.||         |..|.
Human   345 SDT--VELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVI---------PDDPQ-------- 390

  Fly   528 TAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQY 591
                                        :||.:   .:...||:|.||.:.|.. |..|..|...
Human   391 ----------------------------ILMEQ---GEFLNYDIMLGVNQGEGLKFVENIVDSDD 424

  Fly   592 GIEADRRSRILKAYVRNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQ 650
            ||.|......:..:|.|.|.:.     |.|   ||...||||..  :|....|.:||.|| :|.|
Human   425 GISASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWAD--RHNPETRRKTLLALFTDHQ 484

  Fly   651 VVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYT 715
            .||||..|.||||.....:|.|.|.:..:....|......||:::||:.|.|::|....|..|::
Human   485 WVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFS 549

  Fly   716 KTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTK 776
            |.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.||.|....:.||:...|
Human   550 KNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWTRYSQKDQLYLHIGLK 611

  Fly   777 PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAA 841
            |::|.||||::::.||.|:|.|            |.|:|
Human   612 PRVKEHYRANKVNLWLELVPHL------------HNLND-------------------------- 638

  Fly   842 NAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKI---YPDDMMDGDHAGGAASASQDSD 903
                ::.:|..|.:|        ||:.:....||.....:   :|....|        ...|...
Human   639 ----ISQYTSTTTKV--------PSTDITFRPTRKNSVPVTSAFPTAKQD--------DPKQQPS 683

  Fly   904 GFAA----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQMPNNIC 964
            .|:.    |||.||||||:|.|||.||:|.||.:||::||.|....|.                |
Human   684 PFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRR----------------C 732

  Fly   965 GDLETLT---IHAKSDPATILSHHHAMQHHQLP-------------PPEFA--------DIPHRA 1005
            ....|.|   .||:.:....|...|....|:..             ||::.        |:|...
Human   733 SPQRTTTNDLTHAQEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMT 797

  Fly  1006 PPP----PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPH 1040
            |..    |..:..:|......:.:|  |.:..:..|.||
Human   798 PNTITMIPNTIPGIQPLHTFNTFTG--GQNNTLPHPHPH 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	235/663 (35%)
NLGN1	NP_001352852.1	COesterase	52..626	CDD:395084	235/663 (35%)