DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	961	Identity:	304/961 - (31%)
Similarity:	441/961 - (45%)	Gaps:	247/961 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::||..|.:.||..:|:...|.||..:.|:|||:||:|..||.||.:.|.|.||:.|....|.||
Mouse    43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACP 107

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVG----SRDSSGSSSSS 282
            |.|   |....|: .:|....:.|:....|:|||||||||||:|||.:.|    .||
Mouse   108 QNL---HGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRD-------- 160

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
                        .::.:...|....:|     |.||::|:||.||...:||.:||||||:||.::
Mouse   161 ------------EATLNPPDTDIRDSG-----KKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVI 208

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            |||:||||||||||:.. |:.:|  .||||:|.|.||.||.||||.|||||..||:.|.|.||:|
Mouse   209 VVTLNYRLGVLGFLSTG-DQAAK--GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASC 270

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREK 477
            |:.||.|.. .|| ||.:||..||:.::.||:...|.||..::|..|.|..: .....::|||.|
Mouse   271 VNLLILSHH-SEG-LFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDRE-DSTEAVECLRRK 332

  Fly   478 TLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAA 542
            :..:|:...::|..:..||||.:|      ||.||..|.
Mouse   333 SSRELVDQDVQPARYHIAFGPVVD------GDVVPDDPE-------------------------- 365

  Fly   543 AGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQYGIEADRRSRILKAYV 606
                         :||::   .:...||::.||.:.|.. |..:|.:.:.|:.|......:..:|
Mouse   366 -------------ILMQQ---GEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFV 414

  Fly   607 RNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLHSAD 665
            .|.|.:.     |.|   ||...||||..  :....:|.:||.|| :|.|.||||..|..|| ||
Mouse   415 DNLYGYPEGKDVLRE---TIKFMYTDWAD--RDNGEMRRKTLLALFTDHQWVAPAVATAKLH-AD 473

  Fly   666 HRNS-YLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYW 729
            :::. |.|.|.:..:....|:.....||::|||:||.|:||..:.|..|::|.::.||.|||.||
Mouse   474 YQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYW 538

  Fly   730 SNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSF 790
            :||.:||:||:.:..:    |   .:.:|::.:.|:.:.|..|:||:...||:::::|||::::|
Mouse   539 TNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAF 600

  Fly   791 WLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQ 855
            ||.|:|.||.        .|.:|.             :.....|||.:|...
Mouse   601 WLELVPHLHN--------LHTELF-------------TTTTRLPPYATRWPP------------- 631

  Fly   856 VFSLLNLSSPSSSLQRNGTRYG--------------GGKIYPDDMMDGDHAGGAASASQDSDGFA 906
                 ....|.:|    |||..              |.:.|  |...||        |:|
Mouse   632 -----RTPGPGTS----GTRRPPPPATLPPESDIDLGPRAY--DRFPGD--------SRD----- 672

  Fly   907 AYSTALSVTIAIGCSLLILNVLIFAGVYYQRDK------TRLSEPRPQTKLKRQENGQMPNNICG 965
             |||.||||:|:|.|||.||:|.||.:||:||:      .|||.|           |...:.:.|
Mouse   673 -YSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPP-----------GGSGSGVPG 725

  Fly   966 --------------DLETLTIHAK------SDPATILSHHHAMQHHQLPPPEFA--------DIP 1002
                          :.|.:::..|      :|||..|        ....||::.        |:|
Mouse   726 GGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEAL--------RPACPPDYTLALRRAPDDVP 782

  Fly  1003 HRA------------PPPPKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPHA 1041
            ..|            ||||....||. |.|..........|....:|.||:
Mouse   783 LLAPGALTLLPSGLGPPPPPPPPSLH-PFGPFPPPPPTATSHNNTLPHPHS 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	229/649 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	56/96 (58%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	229/649 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		10/59 (17%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836		12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I955
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69317
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8833
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830