DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Nlgn1

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_006535478.1	Gene:	Nlgn1 / 192167	MGIID:	2179435	Length:	863	Species:	Mus musculus

Alignment Length:	951	Identity:	300/951 - (31%)
Similarity:	424/951 - (44%)	Gaps:	217/951 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.|.|:..:|:...|.||..:.|:|||:||.|..||.||...:.||.::.|.:|:||||
Mouse    54 LVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   222 Q-----RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSS 281
            |     |||::        .:|......|..:..|:|:|||||||||||||.:...|.|  ...:
Mouse   119 QNIIDGRLPEV--------MLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRIS--KECA 173

  Fly   282 SSAGSSSSGSGGSSSSSSSSSTSSSSAG-------SGSPAKYPVLVFVHGESYEWNSGNPYDGSV 339
            ...|......||..:...:.....:...       ||.|.  ||:|::||.||...:||.|||||
Mouse   174 RKPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPK--PVMVYIHGGSYMEGTGNLYDGSV 236

  Fly   340 LASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLA 404
            |||||.::|:|:||||||||||:.. |:.:|  .||||:|:|.||.|..|||..|||||..||:.
Mouse   237 LASYGNVIVITVNYRLGVLGFLSTG-DQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVF 298

  Fly   405 GHGTGAACVHFLISSMAVPEGL--------LFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNC 461
            |.|.|.:||:.|..| ...||.        ||.|||..||:.|:.|::...|||||.|:|..|.|
Mouse   299 GSGAGGSCVNLLTLS-HYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGC 362

  Fly   462 -ASDLPHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQ 525
             .||.  ..|::||::|...:|:...::|..:..||||.|||.||         |..|.
Mouse   363 NVSDT--VELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVI---------PDDPQ------ 410

  Fly   526 ASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDV 589
                                          :||.:   .:...||:|.||.:.|.. |..|..|.
Mouse   411 ------------------------------ILMEQ---GEFLNYDIMLGVNQGEGLKFVENIVDS 442

  Fly   590 QYGIEADRRSRILKAYVRNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SD 648
            ..|:.|......:..:|.|.|.:.     |.|   ||...||||..  :|....|.:||.|| :|
Mouse   443 DDGVSASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWAD--RHNPETRRKTLLALFTD 502

  Fly   649 AQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRN 713
            .|.||||..|.||||.....:|.|.|.:..:....|......||:::||:.|.|::|....|..|
Mouse   503 HQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCN 567

  Fly   714 YTKTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFD 774
            ::|.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.||.|....:.||:..
Mouse   568 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWTRYSQKDQLYLHIG 629

  Fly   775 TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISR 839
            .||::|.||||::::.||.|:|.|            |.|:|
Mouse   630 LKPRVKEHYRANKVNLWLELVPHL------------HNLND------------------------ 658

  Fly   840 AANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKI---YPDDMMDGDHAGGAASASQD 901
                  ::.:|..|.:|        ||:.:....||.....:   :|....|        ...|.
Mouse   659 ------ISQYTSTTTKV--------PSTDITLRPTRKNSTPVTSAFPTAKQD--------DPKQQ 701

  Fly   902 SDGFAA----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQMPNN 962
            ...|:.    |||.||||||:|.|||.||:|.||.:||::||.|....|.
Mouse   702 PSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRR--------------- 751

  Fly   963 ICGDLETLT---IHAKSDPATILSHHHAMQHHQLP-------------PPEFA--------DIPH 1003
             |....|.|   .||..:....|...|....|:..             ||::.        |||.
Mouse   752 -CSPQRTTTNDLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDIPL 815

  Fly  1004 RAPPP----PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPH 1040
            ..|..    |..:..:|......:.:|  |.:..:..|.||
Mouse   816 MTPNTITMIPNTIPGIQPLHTFNTFTG--GQNNTLPHPHPH 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	236/665 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	55/96 (57%)
Nlgn1	XP_006535478.1	COesterase	53..646	CDD:365897	236/665 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I955
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm8833
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3146
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850