Protein Alignment Nlg3 and cest-28

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_504691.2
• Gene: cest-28 / 187305
• WormBaseID: WBGene00019654
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 678
• Identity: 171/678 - (25%)
• Similarity: 265/678 - (39%)
• Gaps: 186/678 - (27%)

  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKA 213
            |..:..|..:|...|.|.|.:.::..:   .|:.|.|||:|.|.|   ||..|..|..|..|:..
 Worm     8 LEREKHSEKLNATCGPIQGNVYRIGDK---TVDGYLGIPFAKPLV---RFKKPEPAGTWEEVRDC 66

  Fly   214 DRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGS 278
            .::.|.|||..|...            .:.:.|..:|    ...:||.||::..|
 Worm    67 TKYGPRCPQSGPFAE------------AINFQKDDIP----DEANCLTLNVFSKI---------- 105

  Fly   279 SSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY-DGSVLAS 342
                            |.|.:.:.|.            ||:|::||..||.::...| |.||..:
 Worm   106 ----------------SDSKNFNKTR------------PVMVYIHGGGYECSASRDYCDYSVAGT 142

  Fly   343 --YGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAG 405
              ...::|||:|||:|:|||.   |...:..|.|:.|.|:...|:|::::|.:|||||.:||:.|
 Worm   143 LPLKDVVVVTLNYRVGILGFF---TTGDTVCPGNFALWDLTLGLNWIQKHIESFGGDPGNITIFG 204

  Fly   406 HGTGAACVHFLISSMAVPEGL-LFNRAILMSGSGLAPWSL--VSNPAKYAAIVAHHVNCASDLPH 467
            ...|||||..|..|   |... ||||.|:|||..|..:::  .::.||.....|.|:........
 Worm   205 QSAGAACVDLLALS---PHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEFARHLGYDGTNSQ 266

  Fly   468 AHLMKCLREKTLDQLLSV-PIRPPEFG-FAFGPSIDGVVIDGGDYVPPA-----PGSPAAQAQAQ 525
            . |...::.|.|:::..: ..:.|..| .|:.|::|      .|:.|.:     .|:|
 Worm   267 T-LFNWMKSKPLEEIEKMNGFQVPASGILAWTPNLD------DDFFPKSLDELRIGAP------- 317

  Fly   526 ASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEA-FFSFNSGDV 589
                                                      :.|:|.|....|. ||.|...|.
 Worm   318 ------------------------------------------KKDIMMGFAEHEGLFFEFLIKDP 340

  Fly   590 QYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRD----ETLEALSDAQ 650
            ...:||      ||.||...|.....:.|....|:..::     :..|:.|    .|.|.|.|
 Worm   341 TPPLEA------LKLYVNEYYKKDTGDHFEATRNKIIEF-----YSRNVEDTDEKSTKERLID-- 392

  Fly   651 VVAPAAQTVDL-----HSADHRNS-YLYVFDY--QTRFGDYPQRQGCI---HGEDLPYIFGAPLV 704
            .|..|..|..:     :...|.|: :||:|||  .:.||:..:....:   |..||.|:.|..|.
 Worm   393 FVGDALFTAGVFDNAKNCLKHGNNVWLYIFDYCNPSGFGNQEEFMTFVAPTHCTDLRYVLGEGLY 457

  Fly   705 GGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAY--ESVH 767
            ..|..     |:.|..:.|.:...:|||.:.||||     ||||.         ||..:  ::..
 Worm   458 SDFQP-----TEEEHKMIEKMTTIYSNFAKYGNPN-----EHGSS---------EWEKFTLDNPR 503

  Fly   768 KKYLNFDTKPKLKNHYRAHRLSFWLNLI 795
            :.:.....:.|::|.|...|:.| |.||
 Worm   504 RHFQISYPRGKMRNDYHPDRMKF-LELI 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	166/667 (25%)
cest-28	NP_504691.2	COesterase	17..526	CDD:395084	165/662 (25%)