Protein Alignment Nlg3 and cest-8

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_001359583.1
• Gene: cest-8 / 182818
• WormBaseID: WBGene00007691
• Length: 605
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 155/702 - (22%)
• Similarity: 231/702 - (32%)
• Gaps: 255/702 - (36%)

  Fly   156 RIINTRNGAISGVIV-QLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPV 219
            :||||..|.:.|:.. ..|..|   ...::.:|:|.||:|||||.||.....|.|:..|..:|..
 Worm    19 KIINTSYGKLRGMAEWSDDANH---KFTFKSVPFAKPPIGNLRFAPPQKLDHWDGILDASVYSAA 80

  Fly   220 CPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSA 284
            |      :.|.|...:       .|:          :|||||:||:
 Worm    81 C------MSNSTLTTQ-------SYV----------NEDCLYINIF------------------- 103

  Fly   285 GSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY-DGSVLASY--GQI 346
                              ||.....|    |..|:|:.||.:|...|...: |..:|..|  ..:
 Worm   104 ------------------TSEKCLKS----KCSVIVYFHGGAYNTESATMFSDRFILDRYVHEDV 146

  Fly   347 LVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAA 411
            :.|....||||.|.|....:.|  |..|..:.|.|.||.::...|:.|||||..:|:.||.:|..
 Worm   147 IFVIPAVRLGVFGQLYFGPNAY--LTENLFMFDAILALDFVHNEISNFGGDPEKVTIMGHSSGGT 209

  Fly   412 CVHFL-ISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLR 475
            .|..| .|||..||..||.:.|::|.:|:
 Worm   210 LVEALGFSSMVDPELKLFQQMIMLSSTGM------------------------------------ 238

  Fly   476 EKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGI 540
                            |||      |.:|||....:....|             ..||...|.
 Worm   239 ----------------FGF------DDLVIDNSFTIVEKLG-------------CFNGTKEER-- 266

  Fly   541 AAAGGWGTPGQLENIVLMR-------------KTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYG 592
                  .|....|.:..||             ...:::||...|:.|     |.|...:|::
 Worm   267 ------NTVNVAETLDCMRHIDGYEILRVQQKMELMDQLSFKYLLRG-----APFMLLNGNI--- 317

  Fly   593 IEADRRSRILKAYVRNTYTFHLNEIFATIVNE--------------YTDWERPVQHPINIRDETL 643
              ||.:..          |...|.||.|..:|              :.|:|.||....|.....:
 Worm   318 --ADLKKN----------TSPRNAIFGTTEHEFFDVTEKYLYITVTFLDYENPVAVARNYDGRLM 370

  Fly   644 EAL-----SDAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPL 703
            :.:     .|:..:..:..|.   :|...|:...||.::||      :...:|..|:.|..|
 Worm   371 KNMETMITGDSAAIFVSTATC---AAAMANAGADVFLFETR------QSYSVHVSDMQYFIG--- 423

  Fly   704 VGGFNHFTRNYTKTEISLSEVVMFY---WSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYES 765
                ||...|.|   |.:..:..||   .:||.:.|.|:.                  .|...:.
 Worm   424 ----NHCAHNRT---IDIDILDSFYSKLLTNFTKHGKPSP------------------GWDPVDP 463

  Fly   766 VHKKYLNF--DTK----PKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHH 811
            ....||..  |:|    |.:...|.|..:|||:..:.:..:    ||....|
 Worm   464 GRMNYLELKVDSKARSGPVMLEGYHAKDVSFWVGEMTEFDQ----NVSKMRH 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	150/680 (22%)
cest-8	NP_001359583.1	alpha/beta hydrolases	19..495	CDD:473884	150/680 (22%)