Protein Alignment Nlg3 and cest-19

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_509187.4
• Gene: cest-19 / 180973
• WormBaseID: WBGene00020125
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 700
• Identity: 172/700 - (24%)
• Similarity: 260/700 - (37%)
• Gaps: 213/700 - (30%)

  Fly   137 NSNSNYSPNHDQLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPP 201
            :|:...|..|      :|...:...:|||.|..:..||:   ....::|||:|.||||.|||..|
 Worm    13 HSHLTISTRH------ISPFELRVNSGAIRGERLLTDGQ---DYSVFKGIPFAMPPVGYLRFQMP 68

  Fly   202 VSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYV 266
            ...|.|.||..|.::|.:|.|.:.:  |:....||              |:.:.||||||||::.
 Worm    69 KEPAKWRGVMNATQYSAMCMQNIDE--NDAGEPER--------------YVAHVSEDCLYLNVFS 117

  Fly   267 PIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNS 331
            |......:.:                                       |||:||:||..::..|
 Worm   118 PTPYQYTNDT---------------------------------------YPVIVFIHGGRFQTGS 143

  Fly   332 GNPY-DGSVLASY--GQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAA 393
            |:.. ..::|:::  .:|:.||.|||||.|||.:...   |.||.|.||.|.|.||.|:|.|...
 Worm   144 GSDIPQRAILSNFVSRKIVFVTFNYRLGPLGFASTGD---SVLPGNIGLWDQIWALKWVKANAEV 205

  Fly   394 FGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHH 458
            |||||::|.|.|||||||....|..|... || ||.:.:|||||.|.|..:.:........:...
 Worm   206 FGGDPSNILLMGHGTGAASASLLALSPRA-EG-LFQKVLLMSGSALQPGVVRNTQVNATWNMNDR 268

  Fly   459 VNCASDLPHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQ 523
            ..|.: ...:.|:.|.|:::.:::........:....|.|.||||    |..:|..|
 Worm   269 FGCRA-FNSSELLDCARKRSKEEIFQYKRLHFDDYEEFVPIIDGV----GGILPEPP-------- 320

  Fly   524 AQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVL-MRKTAINKLSRYDLMAGVTRAEA---FFSF 584
                                         |.:.| .|||.|        :.|.|:.|:   ....
 Worm   321 -----------------------------EQLTLHRRKTPI--------VIGTTKDESSLRILLL 348

  Fly   585 NSGDVQY-----------------GIEADRRSRILKAYVRNTY-------TFHLNEIFATIVNEY 625
            |..|:.:                 |.:..:..|::....::.|       :|..:.:|.:::..|
 Worm   349 NEKDLNFSSITWENGETLADNLTLGFKQFQNHRLISQGCKSEYVWTQVDPSFPESVLFNSLLKMY 413

  Fly   626 TD-WERPVQHPINIRDETLEALSDAQVVAPAAQTVDLHSADHRNSYLYVFDY-QTRFGDYPQRQG 688
            :. |                      ..|||:|....:.......|||.||: ...|.|..:
 Worm   414 SHFW----------------------YDAPASQLATYYLKHDLPVYLYSFDHISENFYDIDR--- 453

  Fly   689 CIHGEDLPYIFGAPLVGGFNHFTRNYTK------------TEISLSEVVMFYWSNFVRTGNPNEQ 741
            ..||.|..:|        ||...|...|            .|| .||:|    :||...|.|..:
 Worm   454 AFHGVDKLHI--------FNVTPRFLNKRKDMNWQLDQRVVEI-FSELV----ANFALYGTPTHE 505

  Fly   742 METEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFW 791
            .:.           .:..||:..:....||:....|.::..||.....||
 Worm   506 NDG-----------FSFNWTSTTAKELSYLSITDSPSMQVGYRWQGHVFW 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	167/681 (25%)
cest-19	NP_509187.4	alpha/beta hydrolases	24..544	CDD:473884	167/681 (25%)