Protein Alignment Nlg3 and cest-16

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_741812.2
• Gene: cest-16 / 180905
• WormBaseID: WBGene00020330
• Length: 697
• Species: Caenorhabditis elegans
• Alignment Length: 773
• Identity: 197/773 - (25%)
• Similarity: 293/773 - (37%)
• Gaps: 254/773 - (32%)

  Fly   155 SRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPV 219
            ||.:....|.:.|.|..:||:|   ::.:||:|||.||:|.|||.|||....|.....|..:.|.
 Worm    23 SRSVWVEQGLVRGNIYNIDGKH---IQIFRGVPYAEPPIGELRFKPPVKKTRWHQELPAVEYGPP 84

  Fly   220 CPQRLPDIH-NETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283
            |.|.: |.| |:..|...|.:               |||||||||::.|.     |:...|.:
 Worm    85 CLQFM-DFHKNDKFAKTNMDR---------------QSEDCLYLNVFSPY-----DTDDESKT-- 126

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP-YDGSVLA----SY 343
                                            ||:||::||.|:...|.:. .|..|:|    |.
 Worm   127 --------------------------------YPILVWIHGGSFLAGSADTGIDMEVIAANIVSK 159

  Fly   344 GQILVVTINYRLGVLGFLN-ANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHG 407
            | |..|:||||||.|||:| .|.|   ||..|:|:.|::.||.|::.||..|.|||..:|:.|..
 Worm   160 G-IAFVSINYRLGPLGFMNYQNGD---KLEGNFGIWDMVMALQWIQSNIKQFNGDPTKVTVMGES 220

  Fly   408 TGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSL--VSNPAKYAA--IVAH----------- 457
            .|.|....|..|... .||| ::||:||||.:|.|::  .|.|| |:.  :||:
 Worm   221 AGGAASSLLALSPKT-SGLL-HQAIIMSGSSMAGWAIHRHSQPA-YSVDNLVAYFRCEKWINEDD 282

  Fly   458 ---------------------------HVNC-ASDLPHAHLMKCLREKTLDQLLSVPIRPPEFGF 494
                                       .:|| ..|:.....|.||| |.|:  .|.|:.......
 Worm   283 TKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQMDKMNCLR-KELN--FSSPLFRKALAA 344

  Fly   495 AFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMR 559
            ..|  :..:|:| ||.||                        .:|::               |:|
 Worm   345 ELG--VSKMVVD-GDLVP------------------------SSGVS---------------LVR 367

  Fly   560 KTAINKLSRYDLMAGVTRAE------AFFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIF 618
            ..|     |..:|.||.|.|      .|::.:..|   |::.......:...:.|::....:|..
 Worm   368 NNA-----RIPIMTGVARKEWGHKKAMFYNMHQRD---GLKRSDVEEQVYRIIDNSFHETASEKL 424

  Fly   619 ----------ATIVNEYTDWERPVQHPIN--IRDETLEAL----SDAQVVAPAAQTVDLHSADHR 667
                      ||||       |.::.|.|  |.|:.:.||    ||.:.|||..:.|..:.....
 Worm   425 ANSTVQLIANATIV-------RYLETPNNEFIADQVVGALQKLESDIEFVAPCEREVAAYVDKGV 482

  Fly   668 NSYLYVFDYQTR-------------FGDYP-----------QRQGCIHGEDLPYIFGAPLVGGFN 708
            ..|||.|||..:             ||..|           ..:...||.|..:||.......|.
 Worm   483 PVYLYSFDYVPKSPILESERKIYSLFGTKPVEMKRTEKSEILEKAAFHGLDHAFIFSKGYSSNFE 547

  Fly   709 HFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNF 773
              ...|||.|.::|:::....:|||:.|:|:            .:|:   .|..:.....:|::.
 Worm   548 --ISPYTKREETMSKILCTMLTNFVKNGDPS------------TTRF---SWPIFSGNSSQYVSL 595

  Fly   774 DTKPKLKNHYRAHRLSFWLNLIPDLHKPGGD--NVPAAHHQLHDDDDEDNNIPSDASV 829
            |...||              |..::|.|...  |..|.....:...|.:.::..||.:
 Worm   596 DVPLKL--------------LEGEIHFPDAQFWNTEAELITRYVSKDSETDLDPDADL 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	189/731 (26%)
cest-16	NP_741812.2	alpha/beta hydrolases	23..608	CDD:473884	190/740 (26%)