DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and cest-2.3

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_506510.2	Gene:	cest-2.3 / 179918	WormBaseID:	WBGene00013873	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	687	Identity:	164/687 - (23%)
Similarity:	249/687 - (36%)	Gaps:	218/687 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LSSRIINTRNGAISGVIVQLD----GRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKA 213
            :|:| |....|.|.|.|:...    |.....|  :.||||..||:|.|||..|.....|.||.:.
Worm    16 ISTR-IQLSTGTIEGKILNATYSPFGNQTATV--FLGIPYVEPPIGELRFRKPRLLKSWEGVLET 77

  Fly   214 DRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLP--YLQNQSEDCLYLNIYVPIQVGSRDSS 276
            ..:.|.|                     :.|.::...  ::...||||||.|::
Worm    78 KDYKPAC---------------------MSYWRKTFKNGFVGEISEDCLYANVF----------- 110

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLA 341
                               ::.......:.|          |::.|||......||:.:...:..
Worm   111 -------------------TNQYCLQNKNCS----------VMIVVHGGRLVCESGSAFKPEIFI 146

  Fly   342 S--YGQ---ILVVTINYRLGVLGF--LNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPN 399
            :  .||   |:|||.||||||.||  .|..|.     ..|..:.|::.|:.|:::.|..|||:.:
Worm   147 NNFVGQDRNIVVVTFNYRLGVFGFGVFNGETG-----DTNVAMYDMLEAVKWVRKEIDQFGGNKD 206

  Fly   400 SITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKY--AAIVAHHVNCA 462
            .||:|||..||..:....|| .:.:||| ::.|:||    ||...:|..|.:  ..|||.:|.|
Worm   207 RITMAGHSAGAGLIVDFTSS-TLSKGLL-HQQIVMS----APLQDISKSANFKGMTIVAQNVGC- 264

  Fly   463 SDLPHAH----LMK--------CLREKTLDQLLSVPIRPPEFG-FAFG-PSIDGVVIDGGDYVPP 513
              :|..:    |.|        ||:.|:...||...:...:.. |.|| |.:||..|.  ||
Worm   265 --IPKEYGFRKLSKTQINKTYLCLQNKSAQDLLHAQLSMQQNSTFYFGSPRVDGDFIT--DY--- 322

  Fly   514 APGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRA 578
                                               |..|.|        .|.:...:...|.|..
Worm   323 -----------------------------------PDNLFN--------FNTIYPINTFIGTTTG 344

  Fly   579 EAFFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQ-------HPI 636
            |.      .|..| |...:..||.:..::|.......|:|          |:|.:       :..
Worm   345 EL------RDSLY-ITDPKNDRIKEQLLKNMCEHVGYELF----------EKPEEFTKKCGNYYK 392

  Fly   637 NIRDETLEALS-DAQVVAPAAQTVDLHSADHRNSYLYVFDYQ---TRFGDYPQRQGCIHGEDLPY 697
            |..|  .:.|| |.:..:.|.:..:.|...:...::|.:||:   |.|..|.:.....|.|||.|
Worm   393 NGTD--AQFLSDDMEFYSGAIKVANAHKRANSKVFMYSYDYKGAGTAFHKYLEAPSPHHSEDLIY 455

  Fly   698 IFG---APLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIE 759
            .||   .|.|      .::|.     :..:.....:||:...:|              |..||.:
Worm   456 TFGTSRGPFV------AKDYV-----IERIYSGMLANFINFEDP--------------SPSKTQQ 495

  Fly   760 WTAYESVHKKY--LNFD---TKPKLKNHYRAHRLSFW 791
            |..|....::|  ::||   |.|.:|:||....|.||
Worm   496 WRQYTQEKREYFLIDFDKNFTMPGMKDHYYTRALDFW 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	162/685 (24%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	35/103 (34%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	160/680 (24%)
cest-2.3	NP_506510.2	CemA	<550..>647	CDD:383495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900