Protein Alignment Nlg3 and cest-2.1

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_506508.2
• Gene: cest-2.1 / 179916
• WormBaseID: WBGene00013875
• Length: 675
• Species: Caenorhabditis elegans
• Alignment Length: 839
• Identity: 182/839 - (21%)
• Similarity: 292/839 - (34%)
• Gaps: 259/839 - (30%)

  Fly   149 LPAQLSSRIINTRNGAISGVIVQLD----GRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSG 209
            |...:|:| :....|.|.|.|:...    |.|..  ..:.|||:..||.|||||..|.....|.|
 Worm    13 LHISISTR-VQLSTGTIEGKILTSTYSPLGNHTG--IGFLGIPFVEPPAGNLRFRKPRPPIPWDG 74

  Fly   210 VKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQ-----SEDCLYLNIYVPIQ 269
            :.:...:.|.|                |...:..|        :|.     ||||||.|::....
 Worm    75 ILETKEYKPAC----------------MSDAKKTY--------KNGVGGPISEDCLYANVFTNQY 115

  Fly   270 VGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP 334
            ...|.:..                                        |::.|||......|.:.
 Worm   116 CMKRKNCS----------------------------------------VMIVVHGGRILTESASA 140

  Fly   335 YDGSVLAS--YGQ---ILVVTINYRLGVLGF--LNANTDRYSKLPANYGLMDIIAALHWLKENIA 392
            ::..:|.:  .||   |:|||.|||||..||  ||.     .|..:|.|:.|::.|:.|.::.:.
 Worm   141 FNPEILVNNFVGQGRNIVVVTFNYRLGTFGFGVLNG-----EKGDSNVGMFDMLEAVKWTRKEVH 200

  Fly   393 AFGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAH 457
            .|||:.:.:|:.||..|.:.|....|| .:.:|:| |:.|:|||: |.....::| .|....:|.
 Worm   201 NFGGNKDKLTMVGHSAGGSLVGAFTSS-PLSKGML-NQQIIMSGA-LYQMGKLAN-FKGMTAMAQ 261

  Fly   458 HVNCASD------LPHAHLMK---CLR----EKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGD 509
            ...|..:      |....:.|   |||    ::.||..|.| ::...: :...|.|||..:
 Worm   262 KAGCLPEVFGFRKLSQVRIDKTYSCLRNISAQEVLDAQLWV-LQNTTY-YISVPHIDGEFL---- 320

  Fly   510 YVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAG 574
                                    |.....|.|:|                 .|:.::.   |.|
 Worm   321 ------------------------LNYSDEILASG-----------------TIHPINS---MIG 341

  Fly   575 VTRAEAFFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIR 639
            .|.||........|::   .||::..:||....:        |...:..|..::.|..|......
 Worm   342 TTTAELRDPIYINDLK---NADKKEELLKNLCEH--------IGYELYTEPEEFSRKCQKFYGNG 395

  Fly   640 DETLEALSDAQVVAPAAQTVDLHSADHRNSYLYVFDYQ---TRFGDYPQRQGCIHGEDLPYIFGA 701
            |:......|.:....:.:..:.|::.:...::|.:||:   ..|..|.|.....|.|||.|:||.
 Worm   396 DDAQFLADDMEFYDGSIKVANAHASKNTKVFMYSYDYKDAGPAFKKYAQAPPPHHSEDLIYVFGT 460

  Fly   702 PLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESV 766
            .        ..|:|:.:..:.::....:::||..|||:...|.              :|..|...
 Worm   461 S--------RGNFTEKDYVIEQIYSGMFADFVNFGNPSPSKEQ--------------KWKEYSPE 503

  Fly   767 HKKY--LNFD---TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSD 826
            .::|  ::||   |.|..::.|.:..|.||        ...|....:.|:.           ||.
 Worm   504 KREYFLIDFDKNFTMPGTRDGYYSRALEFW--------STAGTKSFSEHYS-----------PSL 549

  Fly   827 ASVKP--LNPPYISRAANAAAMANFT-------IFTNQVFSLLNLSSPSSSLQR---NGTRYGGG 879
            .|...  |..|.:|.....|...:.|       :...::|.....|.....|.:   ...|.|||
 Worm   550 DSFTTGILIDPIVSHMKGVATGPDKTFEQFEKMLLEREMFLKTLKSERKLELLKEKWRKIRNGGG 614

  Fly   880 KIY------PDDMMDGDHAGGAASASQDSDGFAAYSTALSVTIAIGCSLLILNVLIFAG 932
            :|.      |.:|.||         .:.|.|              |.|||:   :||.|
 Worm   615 RIVERAGNAPMEMRDG---------KKGSRG--------------GVSLLL---IIFGG 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	148/673 (22%)
cest-2.1	NP_506508.2	COesterase	18..533	CDD:395084	148/673 (22%)