Protein Alignment Nlg3 and cest-35.2

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_504398.1
• Gene: cest-35.2 / 178910
• WormBaseID: WBGene00016863
• Length: 544
• Species: Caenorhabditis elegans
• Alignment Length: 670
• Identity: 159/670 - (23%)
• Similarity: 257/670 - (38%)
• Gaps: 170/670 - (25%)

  Fly   149 LPAQLSSRIINTRNGAISGVIVQLDGRHLDP-VEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKK 212
            |..:.::.:.|...|.|.|.:.:    |.|. |..|.|||:|..|:|:|||...|.|..|:....
 Worm     8 LKPEKNTEVFNASCGPIRGNVYE----HGDKIVNGYLGIPFAKAPIGDLRFKKSVEAEKWTQPLD 68

  Fly   213 ADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQ---SEDCLYLNIYVPIQVGSRD 274
            ..::.|.|||        :|||     |.|     ::....|.   .::||.||::.|....:..
 Worm    69 CYKYGPGCPQ--------SAAL-----GAL-----MVSQATNHDFAEDNCLNLNVFAPKWKSAEF 115

  Fly   275 SSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSV 339
            .:|                                      :||:|:.:|..:|....:.:|...
 Worm   116 PNG--------------------------------------FPVMVYFYGGGFEVGFSSMFDDYS 142

  Fly   340 LAS---YGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSI 401
            |..   ...:::||.|||:|.|||. |..|..::  .|:||.|...||.|::::|.:|||||:::
 Worm   143 LTGTLPLKDVILVTPNYRIGPLGFF-ATGDDVAR--GNWGLWDQALALQWVQKHIKSFGGDPSNV 204

  Fly   402 TLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAK---YAAIVAHHVNCAS 463
            |::|...|.|.|.||  |::......|.:.|.|||:...|:.:.|...:   :.....||....:
 Worm   205 TISGTSAGGASVDFL--SLSPHANKYFQKFIPMSGAATCPFGIRSKDVEGLIFREFANHHGYTGN 267

  Fly   464 DLPHAHLMKCLREKTLDQLLSVP-IRPPEFG-FAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQA 526
            |  ...|::..:.:..:..|... .:.|..| |:|.|:.|      ||:.|    .|..:.:.:|
 Worm   268 D--SKSLLQWYQSQDSEIFLKAEGYKCPASGMFSFVPNFD------GDFFP----KPFDELRKEA 320

  Fly   527 -------STAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSF 584
                   |.....|||.|...|   |..||.|:.:..|..:...|            |.|..
 Worm   321 PKLGAIVSIGEYEGLGFEDFYA---GQKTPQQMLSAALGPEVVRN------------REEVV--- 367

  Fly   585 NSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDA 649
                          .|..::|::|....:...|..|:|..:.|:...|           .|....
 Worm   368 --------------KRAAESYLKNGGNENEENIAKTLVEIFGDYYFSV-----------GAFDTV 407

  Fly   650 QVVAPAAQTVDLHSADHRNSYLYVFDY-----QTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNH 709
            :.:.....||          |||.|:|     ...||.........||.||.||||        .
 Worm   408 RSLVKYGNTV----------YLYSFNYFNPNTPIVFGKNRPFNAANHGSDLRYIFG--------E 454

  Fly   710 FTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQ---METEHGSRQERSRYKTIEWTAYESVHKKYL 771
            .|..::|.:..:.:::..|.:||.:.||||.:   :..|..|.....||..|::...|...
 Worm   455 GTGEFSKEDRQVMDMMGTYHTNFAKYGNPNGKGVSVPWEKYSLDNPGRYFKIDYPKCEMAD---- 515

  Fly   772 NF-DTKPKLKNHYRAHRLSF 790
            || |.:.|:.:....|.:.:
 Worm   516 NFLDGRHKIIDEVNEHGIQY 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	158/665 (24%)
cest-35.2	NP_504398.1	COesterase	18..517	CDD:395084	153/640 (24%)