Protein Alignment Nlg3 and cest-10

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_501133.3
• Gene: cest-10 / 177493
• WormBaseID: WBGene00016595
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 672
• Identity: 146/672 - (21%)
• Similarity: 237/672 - (35%)
• Gaps: 218/672 - (32%)

  Fly   153 LSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFS 217
            :.|.|:.|..|.::|  .|:...||     ::.||:|.||:|.|||..|..|..|:||:.|..:.
 Worm    19 VDSVIVETSLGKLNG--DQIGNFHL-----FKKIPFAKPPLGKLRFQKPQPAETWNGVRNAKDYG 76

  Fly   218 PVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSS 282
            |.|...    .:.|..:::.                 ..||||:|||:
 Worm    77 PACMSN----SSTTKTVQKW-----------------VDEDCLHLNIF----------------- 103

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY-DGSVLASYG-- 344
                                ||.:...|.:.|   |::::||.:..::|...: |..:|.:|.
 Worm   104 --------------------TSETCLKSKNCA---VVIYLHGGNLHYDSAVMFNDTFLLHTYASQ 145

  Fly   345 QILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTG 409
            :|:.|....|||:  |.:...:..|..|.|..|.|::.|:.:.|.:|..|||:....||.||..|
 Worm   146 EIVFVIPAVRLGI--FSHFVVEDQSIAPNNLALFDMLQAMEFAKSDIHNFGGNNKRTTLLGHSYG 208

  Fly   410 AACVHFLISSMAVPEGL-LFNRAILMSGSGLAPWSLVSNPAKYAAI---------VAHHVNCASD 464
            ......|..|..|...| ||.:.|.|           |:|..:..:         .|.|.||
 Worm   209 GTVASMLSFSTKVNTDLSLFQQYISM-----------SSPTNFDTLELQVERTYRFAEHANC--- 259

  Fly   465 LP-----------HAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSP 518
            ||           ..::..||::|:..:||.:.....|.|:   |...|.|:.|          |
 Worm   260 LPKNSKFMRKNQKEVYMRDCLKKKSASELLRIQRSLEEAGY---PVYGGSVMRG----------P 311

  Fly   519 AAQAQAQAS-TAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFF 582
            ..|...:.. ..:.|.:....|..         :.|::|            ||....:.:|..|.
 Worm   312 IFQEVLERDFMDSPNNITSLTGCT---------KYESLV------------YDHYRNMGKALGFE 355

  Fly   583 SFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALS 647
            ::...:.:|..:: :..:|....|:|.....|.:| .|.||:......|..|
 Worm   356 NYEEVNEKYRSDS-KEGKIEFDNVKNATQIMLIQI-RTRVNKILKKNIPAYH------------- 405

  Fly   648 DAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGA-PLVGGFNHFT 711
                                      ::|.     ||:...  |.:||.:|.|. |.:...|
 Worm   406 --------------------------YEYA-----YPKHAN--HTDDLFFIMGVHPFIQDEN--- 434

  Fly   712 RNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDT- 775
                  ||.|.......:.||::||||....:   |:....|.|..:.|           |..|
 Worm   435 ------EIKLGNFYRSMFLNFIKTGNPGNGCD---GANLNGSTYFEVNW-----------NETTG 479

  Fly   776 -KPKLKNHYRAHRLSFWL-NLI 795
             :|.:||::....|.:|. |:|
 Worm   480 ERPVMKNNFEQKILDYWTKNMI 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	143/664 (22%)
cest-10	NP_501133.3	alpha/beta hydrolases	20..503	CDD:473884	146/671 (22%)