Protein Alignment Nlg3 and cest-5.2

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 822
• Identity: 173/822 - (21%)
• Similarity: 270/822 - (32%)
• Gaps: 311/822 - (37%)

  Fly   156 RIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVC 220
            |||.|..|       :|:|:.....:.:|.||:|.||:|.|||..|.||..|:||..|..:.|.|
 Worm    22 RIIKTSLG-------RLEGKQSGKYQLFRRIPFAKPPIGTLRFQKPESAEKWNGVWNATEYGPAC 79

  Fly   221 ---------PQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSS 276
                     ||:..|                              ||||::||:
 Worm    80 MSNSTWTQSPQKWVD------------------------------EDCLHVNIF----------- 103

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPY-DGSVL 340
                                      ||.....|...|   |:|::||....::|...: |..:|
 Worm   104 --------------------------TSDKCLKSKDCA---VVVYIHGGEIVFDSAVMFNDTFLL 139

  Fly   341 ASY--GQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITL 403
            .|:  ..:::|...:|||:......:....:  |.|..|.|||.|..::|..|..||||...|||
 Worm   140 ESFVKQDVILVIPAFRLGIFSHFTVHDQNIA--PNNLALYDIILAQEFVKSEIHNFGGDIQKITL 202

  Fly   404 AGHGTGAACVHFLISSMAVPEGL-LFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLP- 466
            .||..|......:..|..:.:.| ||.|.|:||.:..  :..:....:.:..|..|..|:  :|
 Worm   203 FGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQY--FDTLEEQIERSDRVVKHAGCS--VPT 263

  Fly   467 -----------HAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAA 520
                       ..::||||::.:..:||||.....|.|:   |.|..:|:.|    |..|...:.
 Worm   264 NLARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAGY---PDIGNLVLRG----PLFPDVTSL 321

  Fly   521 QAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEA----- 580
            :                             .||:..::           .::||.|:.|:
 Worm   322 E-----------------------------MLESPKMI-----------PMLAGCTKFESDDEDE 346

  Fly   581 --FFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETL 643
              |...:.| ::..||.|.:.|                         .|.|..:....|..|:|
 Worm   347 THFIGKHFG-LENPIECDEKYR-------------------------KDLENGIFDRQNHSDKT- 384

  Fly   644 EALSDAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFN 708
                 ..::.|....||........:|||.|       .||:.  ..|.:||.||.      |.:
 Worm   385 -----QAIMVPTKLRVDQLRKHGVPAYLYEF-------TYPKH--AFHTDDLYYIM------GIH 429

  Fly   709 HFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNF 773
            .|.::  :.|..|.:|......||::.|.|....|.   |....|.|..|.|.  |:..:
 Worm   430 PFEKD--ENEEHLEKVYRNMLINFIKFGEPGMGFEM---SDLNESTYFEIYWN--ETTGQ----- 482

  Fly   774 DTKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNI----PSDASVKPLNP 834
              ||:::..:..:..::||..:.:.                     |.||    .:..|:||
 Worm   483 --KPRMRKRFEENITNYWLKEMMEY---------------------DRNITKAKKNQRSIKP--- 521

  Fly   835 PYISRAANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKIYPDDMMDGDHAGGAASAS 899
                            :|..:.|.:       .||::|               ||.|.
 Worm   522 ----------------VFKTEQFYV-------KSLEKN---------------DGSHE------- 541

  Fly   900 QDSDGFAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTR 941
                           .|.|...|:|..|...||.|...:.||
 Worm   542 ---------------FIGIIIVLIIFLVGFIAGRYCCENGTR 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	147/666 (22%)
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	147/666 (22%)