DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and cest-25

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_497609.1	Gene:	cest-25 / 175390	WormBaseID:	WBGene00022178	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	163/696 - (23%)
Similarity:	269/696 - (38%)	Gaps:	183/696 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NSNSNSNYSPNHDQLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFM 199
            :.::..:|.|          ||.:.|..|.|.|..:..:|.  ..|:|::|||||:||:|||||.
Worm     6 SKHTTPHYPP----------SRQVLTSYGPIEGRRLIHEGE--KQVDAFQGIPYAAPPIGNLRFA 58

  Fly   200 PPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNI 264
            .|.....|:.|::...|.....|:                   :::  |.|....||||.|.|||
Worm    59 LPQPHEKWTEVRETKSFGARGIQK-------------------DHV--LSPKTSPQSEDNLTLNI 102

  Fly   265 YVPIQVGSRDSSGSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEW 329
            :.|:.                                 |..:..|      :||::::||..:..
Worm   103 FTPVW---------------------------------TPKNETG------FPVILYIHGGGFVS 128

  Fly   330 NSGNPYDGSVLASY---GQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENI 391
            :|.:.|....:..:   ..::||||.||||.|||.   |...|.:|.|..|.|::.||.|:||||
Worm   129 DSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFW---TTGDSSIPDNVALHDMVFALKWVKENI 190

  Fly   392 AAFGGDPNSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVA 456
            ..|.||||:|||.|...|.|.|.||  |::.....||.:.|.|.|:....|::...|.......|
Worm   191 GLFNGDPNNITLMGQSAGGASVDFL--SISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRA 253

  Fly   457 HHVNCASDLPHAHLMKCLREKTLDQLLSV-------PIRPPEFGFAFGPSIDGVVIDGGDYVPPA 514
            ..:.....:.....::.|||...|:..|.       ....||  ...||..|.:.|       |.
Worm   254 QEIGVFDGMNTLDWVEKLRELPADKFASALNMEAVDTKTDPE--LLIGPKYDNLFI-------PR 309

  Fly   515 PGSPAAQAQAQASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAE 579
            |                                       ::.:||.|..|    ..:.|..::|
Worm   310 P---------------------------------------VMELRKEAPMK----PRLLGCAKSE 331

  Fly   580 ----AFFSFNSGDVQYGIEADRRSRI------LKAYVRNTYTFHLNEIFATIVNEYT--DWERPV 632
                |||..|:....:.::.|..:.:      |||   ..|.....|....|..:::  :|:|.:
Worm   332 GLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKA---RDYQEKALEKLIEIGTDHSKEEWQRAM 393

  Fly   633 QHPINIRDETLEALSDAQVVAPAAQT-----VDLHSADHRNSYLY-VFDYQTRFGDYPQRQGCIH 691
               ::::.::...:...|.|....:|     :.::|.|:.|...| :..::..|.|      ..|
Worm   394 ---VDLKGDSFLNVGIQQNVLDVLETQPSTPIYMYSFDYCNPKAYGIMGFKLPFKD------ATH 449

  Fly   692 GEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPN-EQMETEHGSRQERSRY 755
            ..|:.|:.|..:|..|     ::.:.:..:.|:....|:||.:.|||| |..:..|  .:|:...
Worm   450 CTDISYVVGNHIVNSF-----DFNEEDYKMIEITTRLWTNFAKYGNPNGEGDDVAH--LEEKWEP 507

  Fly   756 KTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIPDLHKP 801
            .|||      ..:.::....:|||.:.|:..|..|...|:.:...|
Worm   508 ATIE------SPQTHMALTLQPKLHHVYKQGRPLFMAKLLKEARPP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	158/668 (24%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	39/99 (39%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	156/661 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810