DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and ace-2

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_491141.1	Gene:	ace-2 / 171905	WormBaseID:	WBGene00000036	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	741	Identity:	178/741 - (24%)
Similarity:	277/741 - (37%)	Gaps:	186/741 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            :::|..|.|.||....||.   .|.|:.|:|||.||:|:.||........|||..:|...:..|.
Worm    40 VVHTPLGTIRGVGQTFDGA---KVSAFLGVPYAKPPIGSRRFKMAEMIDRWSGELEARTLAKTCY 101

  Fly   222 QRLPDIHNETAALERM-PKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSSAG 285
            ..:.....:....|.. |.|.:             |||||.:||:||     .|..||
Worm   102 LTIDSAFPQFPGAEMWNPPGAI-------------SEDCLNMNIWVP-----EDHDGS------- 141

  Fly   286 SSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP----YDGSVLASYGQI 346
                                            |:|:::|..:  .||.|    |.|||.|:....
Worm   142 --------------------------------VMVWIYGGGF--FSGTPSLDLYSGSVFAAKEHT 172

  Fly   347 LVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAA 411
            :||.:|||||..|||....|  |.:..|.||||...||.|:.|||.|||||.:.:||.|...|:|
Worm   173 IVVNVNYRLGPFGFLYFGDD--SPIQGNMGLMDQQLALRWVHENIGAFGGDRSRVTLFGESAGSA 235

  Fly   412 CVHFLISSMAVPEG-LLFNRAILMSGSGLAPWSLVSNPA--KYAAIVAHHVNCASDLPHAHLMKC 473
            ..   .:.:..|.. ..|...|..|||.:..|:..:.|.  ..:..:|..|||:|...:| ::||
Worm   236 ST---TAHLFAPNSHKYFRNIIAKSGSIINSWASATPPTMLDLSFRLAKKVNCSSPDMNA-IVKC 296

  Fly   474 LREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEA 538
            ||        |||....:   |...:|.|.:           |.|...|....|:.| |...|:
Worm   297 LR--------SVPAHLVQ---AEADNISGDI-----------GPPMTFAYVPVSSDA-NFFQGD- 337

  Fly   539 GIAAAGGWGTPGQLENIVLMRKTAINKLSRYD--LMAGVTRAEAF-------------FSFN--- 585
                              :.:|.| ||..:.|  ::.|..:.|..             |:||
Worm   338 ------------------VFQKLA-NKQFKKDVNIIFGSVKDEGTYWLPYYMSLPKYGFAFNHTI 383

  Fly   586 SGDVQYG---IEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALS 647
            |.:..:.   |..|.....::|::  .|......:....:|.|.............||.....|.
Worm   384 SAEDPHNRALITRDHYEESMRAFM--PYFAGSKLVLNAFMNSYEHVSTSNVPEERYRDGVARFLG 446

  Fly   648 DAQVVAPAAQTVDLHSAD-HRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFT 711
            |...........||.|.: ..|.|:|.|.|::....:|:..|.:||.::.|.||.|.... :.:.
Worm   447 DLFFTCSLIDFADLISDNIFGNVYMYYFTYRSSANPWPKWMGVMHGYEIEYAFGQPYWRP-HLYD 510

  Fly   712 RNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTK 776
            :.:.:.|..||.::|..|:||..||..:.                  .|..|..:.:|.:... :
Worm   511 QTHLEDEKRLSSIIMQIWANFANTGRTDS------------------FWPQYNKIERKAIELG-E 556

  Fly   777 PKLKNHYRAHRLSFWLNLIPDLHKPGG-----DNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPY 836
            ..|:..:|         :|.|:|  ||     |...|...|.:.:|.....  ..||.:.|
Worm   557 TTLQGKHR---------IISDVH--GGFCRMIDEAKAFVKQKNANDCRTTR--KSASTEDL---- 604

  Fly   837 ISRAANAAAMANFTIFTNQVFSLLNL 862
             :.:::...:.:..::.:.:.|.::|
Worm   605 -TSSSSTTYLFSIIVYLSILISYISL 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	164/663 (25%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	42/100 (42%)
ace-2	NP_491141.1	COesterase	33..546	CDD:278561	161/637 (25%)
ace-2	NP_491141.1	Aes	<135..>233	CDD:223730	46/145 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910