DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Cel

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_034015.1	Gene:	Cel / 12613	MGIID:	88374	Length:	599	Species:	Mus musculus

Alignment Length:	732	Identity:	194/732 - (26%)
Similarity:	287/732 - (39%)	Gaps:	178/732 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 LPAQLSSRI--INTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVK 211
            |.|..::::  :.|..|.:.||..:|.....|.|:.::|||:|:...    ...|.....|.|..
Mouse    15 LAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKT----LENPQRHPGWQGTL 75

  Fly   212 KADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSS 276
            ||..|...|.|......|                    .|.|   ||||||||:||        .
Mouse    76 KATNFKKRCLQATITQDN--------------------TYGQ---EDCLYLNIWVP--------Q 109

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNP------- 334
            |....|.                               ..||:|:::|.::...||..
Mouse   110 GRKQVSH-------------------------------NLPVMVWIYGGAFLMGSGQGANFLKNY 143

  Fly   335 -YDGSVLASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDP 398
             |||..:|:.|.::|||.|||:|.||||:...   :.||.|:||.|...|:.|:|.|||||||||
Mouse   144 LYDGEEIATRGNVIVVTFNYRVGPLGFLSTGD---ANLPGNFGLRDQHMAIAWVKRNIAAFGGDP 205

  Fly   399 NSITLAGHGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCAS 463
            ::||:.|...|||.|.  :.:::.....|..|||..||..|:||::..||..:|..:|..|.|.:
Mouse   206 DNITIFGESAGAASVS--LQTLSPYNKGLIRRAISQSGMALSPWAIQKNPLFWAKTIAKKVGCPT 268

  Fly   464 DLPHAHLMKCLR---EKTLDQLLSVPIRPPEFG----FAFGPSIDGVVIDGGDYVPPAPGSPAAQ 521
            : ....:..||:   .:.|.....:|::..|:.    .||.|.||      ||::|..|.: ...
Mouse   269 E-DTGKMAACLKITDPRALTLAYKLPVKKQEYPVVHYLAFIPVID------GDFIPDDPIN-LYN 325

  Fly   522 AQAQASTAAG-NGLGGE--AGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFS 583
            ..|.....|| |.:.|.  |.|....           |...|..:.:...|.|::|.|.|:..
Mouse   326 NTADIDYIAGINNMDGHLFATIDVPA-----------VDKTKQTVTEEDFYRLVSGHTVAKGL-- 377

  Fly   584 FNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTD-W-ERPVQHPINIRDETLEAL 646
                   .|.:|               ||.:          ||: | :.|.|.  |::...:...
Mouse   378 -------KGAQA---------------TFDI----------YTESWAQDPSQE--NMKKTVVAFE 408

  Fly   647 SDAQVVAPAAQTVDLHSADHRN--SYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNH 709
            :|...:.|....:..|.|..::  :|.|:|.:.:|...||:..|..|.:||.|:||.|.....
Mouse   409 TDVLFLIPTEIALAQHKAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPL-- 471

  Fly   710 FTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFD 774
               .|...:.::|:.::.||:||.|:|:||          ...|...| .|..|...:..||:..
Mouse   472 ---GYRPQDRAVSKAMIAYWTNFARSGDPN----------MGNSPVPT-HWYPYTLENGNYLDIT 522

  Fly   775 ---TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDN---VPAAHHQLHDDDDEDNNIPSDAS-VKPL 832
               |...:|.|.|...|.||......|....||.   .|.     .||.:...:.|||.| |.|:
Mouse   523 KTITSASMKEHLREKFLKFWAVTFEVLPTVTGDQDTLTPP-----EDDSEVAPDPPSDDSQVVPV 582

  Fly   833 NPPYISRAANAAAMANF 849
            .|...|..|...|...|
Mouse   583 PPTDDSVEAQMPATIGF 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	174/666 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	43/104 (41%)
Cel	NP_034015.1	COesterase	26..542	CDD:278561	173/657 (26%)
		Aes	<117..>247	CDD:223730	54/134 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..599		15/50 (30%)
		4 X 11 AA tandem repeats, O-glycosylated region	559..588		10/33 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910