Protein Alignment Nlg3 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 961
• Identity: 303/961 - (31%)
• Similarity: 440/961 - (45%)
• Gaps: 247/961 - (25%)

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::||..|.:.||..:|:...|.||..:.|:|||:||:|..||.||.:.|.|.||:.|....|.||
  Rat    43 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACP 107

  Fly   222 QRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVG----SRDSSGSSSSS 282
            |.|   |....|: .:|....:.|:....|:|||||||||||:|||.:.|    .||
  Rat   108 QNL---HGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRD-------- 160

  Fly   283 SAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQIL 347
                        .::.:...|....:|     |.||::|:||.||...:||.:||||||:||.::
  Rat   161 ------------EATLNPPDTDIRDSG-----KKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVI 208

  Fly   348 VVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAAC 412
            |.|:||||||||||:.. |:.:|  .||||:|.|.||.||.||||.|||||..||:.|.|.||:|
  Rat   209 VATLNYRLGVLGFLSTG-DQAAK--GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASC 270

  Fly   413 VHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMKCLREK 477
            |:.||.|.. .|| ||.:||..||:.::.||:...|.||..::|..|.|..: .....::|||.|
  Rat   271 VNLLILSHH-SEG-LFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDRE-DSTEAVECLRRK 332

  Fly   478 TLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGIAA 542
            :..:|:...::|..:..||||.:|      ||.||..|.
  Rat   333 SSRELVDQDVQPARYHIAFGPVVD------GDVVPDDPE-------------------------- 365

  Fly   543 AGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQYGIEADRRSRILKAYV 606
                         :||::   .:...||::.||.:.|.. |..:|.:.:.|:.|......:..:|
  Rat   366 -------------ILMQQ---GEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFV 414

  Fly   607 RNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQVVAPAAQTVDLHSAD 665
            .|.|.:.     |.|   ||...||||..  :....:|.:||.|| :|.|.||||..|..|| ||
  Rat   415 DNLYGYPEGKDVLRE---TIKFMYTDWAD--RDNGEMRRKTLLALFTDHQWVAPAVATAKLH-AD 473

  Fly   666 HRNS-YLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYW 729
            :::. |.|.|.:..:....|:.....||::|||:||.|:||..:.|..|::|.::.||.|||.||
  Rat   474 YQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYW 538

  Fly   730 SNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSF 790
            :||.:||:||:.:..:    |   .:.:|::.:.|:.:.|..|:||:...||:::::|||::::|
  Rat   539 TNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAF 600

  Fly   791 WLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQ 855
            ||.|:|.||.        .|.:|.             :.....|||.:|...
  Rat   601 WLELVPHLHN--------LHTELF-------------TTTTRLPPYATRWPP------------- 631

  Fly   856 VFSLLNLSSPSSSLQRNGTRYG--------------GGKIYPDDMMDGDHAGGAASASQDSDGFA 906
                 ....|.:|    |||..              |.:.|  |...||        |:|
  Rat   632 -----RTPGPGTS----GTRRPPPPATLPPESDIDLGPRAY--DRFPGD--------SRD----- 672

  Fly   907 AYSTALSVTIAIGCSLLILNVLIFAGVYYQRDK------TRLSEPRPQTKLKRQENGQMPNNICG 965
             |||.||||:|:|.|||.||:|.||.:||:||:      .|||.|           |...:.:.|
  Rat   673 -YSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPP-----------GGSGSGVPG 725

  Fly   966 --------------DLETLTIHAK------SDPATILSHHHAMQHHQLPPPEFA--------DIP 1002
                          :.|.:::..|      :|||..|        ....||::.        |:|
  Rat   726 GGPLLPTAGRELPPEEELVSLQLKRGGGVGADPAEAL--------RPACPPDYTLALRRAPDDVP 782

  Fly  1003 HRA------------PPPPKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPHA 1041
            ..|            ||||....||. |.|..........|....:|.||:
  Rat   783 LLAPGALTLLPSGLGPPPPPPPPSLH-PFGPFPPPPPTATSHNNTLPHPHS 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	228/649 (35%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	228/649 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661		10/59 (17%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836		12/43 (28%)