DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg3 and Nlgn1

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	XP_038957495.1	Gene:	Nlgn1 / 116647	RGDID:	621117	Length:	863	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	299/951 - (31%)
Similarity:	425/951 - (44%)	Gaps:	217/951 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.|.|:..:|:...|.||..:.|:|||:||.|..||.||...:.||.::.|.:|:||||
  Rat    54 LVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVCP 118

  Fly   222 Q-----RLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSS 281
            |     |||::        .:|......|..:..|:|:|||||||||||||.:...|.|  ...:
  Rat   119 QNIIDGRLPEV--------MLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRIS--KECA 173

  Fly   282 SSAGSSSSGSGGSSSSSSSSSTSSSSAG-------SGSPAKYPVLVFVHGESYEWNSGNPYDGSV 339
            ...|......||..:.:.:.....:...       ||.|.  ||:|::||.||...:||.|||||
  Rat   174 RKPGKKICRKGGPLTKTQTDDLGDNDRAEDEDIRDSGGPK--PVMVYIHGGSYMEGTGNLYDGSV 236

  Fly   340 LASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLA 404
            |||||.::|:|:||||||||||:.. |:.:|  .||||:|:|.||.|..|||..|||||..||:.
  Rat   237 LASYGNVIVITVNYRLGVLGFLSTG-DQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVF 298

  Fly   405 GHGTGAACVHFLISSMAVPEGL--------LFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNC 461
            |.|.|.:||:.|..| ...||.        ||.|||..||:.|:.|::...|||||.|:|..|.|
  Rat   299 GSGAGGSCVNLLTLS-HYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGC 362

  Fly   462 -ASDLPHAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQ 525
             .||.  ..|::||::|...:|:...::|..:..||||.|||.||         |..|.
  Rat   363 NVSDT--VELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVI---------PDDPQ------ 410

  Fly   526 ASTAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDV 589
                                          :||.:   .:...||:|.||.:.|.. |..|..|.
  Rat   411 ------------------------------ILMEQ---GEFLNYDIMLGVNQGEGLKFVENIVDS 442

  Fly   590 QYGIEADRRSRILKAYVRNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SD 648
            ..|:.|......:..:|.|.|.:.     |.|   ||...||||..  :|....|.:||.|| :|
  Rat   443 DDGVSASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWAD--RHNPETRRKTLLALFTD 502

  Fly   649 AQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRN 713
            .|.||||..|.||||.....:|.|.|.:..:....|......||:::||:.|.|::|....|..|
  Rat   503 HQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCN 567

  Fly   714 YTKTEISLSEVVMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFD 774
            ::|.::.||.|||.||:||.:||:||:.:..:    |   .:.:|::.:.||.|....:.||:..
  Rat   568 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVAWTRYSQKDQLYLHIG 629

  Fly   775 TKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISR 839
            .||::|.||||::::.||.|:|.|            |.|:|
  Rat   630 LKPRVKEHYRANKVNLWLELVPHL------------HNLND------------------------ 658

  Fly   840 AANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGGGKI---YPDDMMDGDHAGGAASASQD 901
                  ::.:|..|.:|        ||:.:....||.....:   :|....|        ...|.
  Rat   659 ------ISQYTSTTTKV--------PSTDITLRPTRKNSTPVTSAFPTAKQD--------DPKQQ 701

  Fly   902 SDGFAA----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQMPNN 962
            ...|:.    |||.||||||:|.|||.||:|.||.:||::||.|....|.
  Rat   702 PSPFSVDQRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVHRR--------------- 751

  Fly   963 ICGDLETLT---IHAKSDPATILSHHHAMQHHQLP-------------PPEFA--------DIPH 1003
             |....|.|   .||..:....|...|....|:..             ||::.        |:|.
  Rat   752 -CSPQRTTTNDLTHAPEEEIMSLQMKHTDLDHECESIHPHEVVLRTACPPDYTLAMRRSPDDVPL 815

  Fly  1004 RAPPP----PKHMKSLQDPGGGGSVSGAVGVSGVVQMPPPH 1040
            ..|..    |..:..:|......:.:|  |.:..:..|.||
  Rat   816 MTPNTITMIPNTIPGIQPLHTFNTFTG--GQNNTLPHPHPH 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	236/665 (35%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	55/96 (57%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	236/665 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1599
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	1	1.000	-	-		mtm9080
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970