Protein Alignment Nlg3 and CES1

DIOPT Version :9

• Sequence 1: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 695
• Identity: 188/695 - (27%)
• Similarity: 287/695 - (41%)
• Gaps: 189/695 - (27%)

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            |..:::|.:|.:.|..|.|:| ...||..:.|||:|.||:|.|||.||..|..||.||.|..:.|
Human    23 SPPVVDTVHGKVLGKFVSLEG-FAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPP 86

  Fly   219 VCPQ--RLPDIHNE--TAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSS 279
            :|.|  :...:.:|  |...|.:|      ||        .||||||||||.|..:..::
Human    87 MCTQDPKAGQLLSELFTNRKENIP------LK--------LSEDCLYLNIYTPADLTKKN----- 132

  Fly   280 SSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYG 344
                                               :.||:|::||......:.:.|||..||::.
Human   133 -----------------------------------RLPVMVWIHGGGLMVGAASTYDGLALAAHE 162

  Fly   345 QILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTG 409
            .::||||.||||:.||.:.. |.:|:  .|:|.:|.:|||.|:::|||:|||:|.|:|:.|...|
Human   163 NVVVVTIQYRLGIWGFFSTG-DEHSR--GNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAG 224

  Fly   410 AACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSL------VSNPAKYAAIVAHHVNCASDLPHA 468
            ...|..|:.|.....  ||:|||  |.||:|..|:      |...|:..||.|   .|.: ...|
Human   225 GESVSVLVLSPLAKN--LFHRAI--SESGVALTSVLVKKGDVKPLAEQIAITA---GCKT-TTSA 281

  Fly   469 HLMKCLREKTLDQLLSVPIR-----------PPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQA 522
            .::.|||:||.::||...::           |.|.....|..|||:::        .......||
Human   282 VMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLL--------LKTPEELQA 338

  Fly   523 QAQASTAAGNGLGGEAGI-AAAGGWGTPGQLENIVLM-----RKTAINKL-SRYDLMAGVTRAEA 580
            :....|     :....|| ....||..|.||.:..|.     :|||::.| ..|.|:.
Human   339 ERNFHT-----VPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVC------- 391

  Fly   581 FFSFNSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEY---TDWERPVQHPINIRDET 642
                                |.|            |:......:|   ||      ..:..:|..
Human   392 --------------------IAK------------ELIPEATEKYLGGTD------DTVKKKDLF 418

  Fly   643 LEALSDAQVVAPAAQTVDLHSADHRN----SYLYVFDYQTRFGDYPQRQGCI--HGEDLPYIFGA 701
            |:.::|.....|:.    :.:.:||:    :|:|.|.|:..|....:.:..|  ||::|..:|||
Human   419 LDLIADVMFGVPSV----IVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGA 479

  Fly   702 PLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESV 766
            |.:      ....::.||.||::||.:|:||.|.||||.: ...|             |..|..
Human   480 PFL------KEGASEEEIRLSKMVMKFWANFARNGNPNGE-GLPH-------------WPEYNQ- 523

  Fly   767 HKKYLNFDTKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHH 811
            .:.||......:.....:...::||.||..   |...:..|...|
Human   524 KEGYLQIGANTQAAQKLKDKEVAFWTNLFA---KKAVEKPPQTEH 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	181/673 (27%)
		Aes	<313..>410	CDD:223730	39/96 (41%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	180/671 (27%)
		Aes	<122..>240	CDD:223730	46/162 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740