DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg3 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	671	Identity:	179/671 - (26%)
Similarity:	283/671 - (42%)	Gaps:	174/671 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            |..::||..|.:.|..|.|:| ...||..:.|:|:|.||:|:|||.||..|..||.||....:.|
Mouse    22 SPPVVNTVKGKVLGKYVNLEG-FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPP 85

  Fly   219 VCPQR------LPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSG 277
            :|.|.      |.::.  |...|.:|   |::           ||||||||||.|..:
Mouse    86 MCSQDAVGGQVLSELF--TNRKENIP---LQF-----------SEDCLYLNIYTPADL------- 127

  Fly   278 SSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLAS 342
                                     |.:|        :.||:|::||........:.|||..|::
Mouse   128 -------------------------TKNS--------RLPVMVWIHGGGLVVGGASTYDGLALSA 159

  Fly   343 YGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHG 407
            :..::||||.||||:.||.:.. |.:|:  .|:|.:|.:|||.|:::|||.|||:|.|:|:.|..
Mouse   160 HENVVVVTIQYRLGIWGFFSTG-DEHSR--GNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGES 221

  Fly   408 TGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLMK 472
            .|...|..|:.|.....  ||:|||..||..|....:.::....|.:||....|.: ...|.::.
Mouse   222 AGGFSVSVLVLSPLAKN--LFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKT-TTSAVMVH 283

  Fly   473 CLREKTLDQLLSVPIR----------PPEFGFAFGPS-IDGVVIDGGDYVPPAPGSPAAQAQAQA 526
            |||:||.|:||...::          .|:..:.|.|: |||||:      |.||....|: ::.:
Mouse   284 CLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVL------PKAPEEILAE-KSFS 341

  Fly   527 STAAGNGLGGEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQY 591
            :.....|:..:     ..||..|               .|..|.|..|
Mouse   342 TVPYIVGINKQ-----EFGWIIP---------------TLMGYPLAEG----------------- 369

  Fly   592 GIEADRR---SRILKAYVRNTYTFHLNEIFATIVNEY----TDWERPVQHPINIRDETLEALSDA 649
              :.|::   |.:.|:|.    |..::|....:|.|.    ||      .....:|...:.::|.
Mouse   370 --KLDQKTANSLLWKSYP----TLKISENMIPVVAEKYLGGTD------DLTKKKDLFQDLMADV 422

  Fly   650 QVVAPAAQTVDLHSADHR----NSYLYVFDYQTRFGDYPQRQGCI--HGEDLPYIFGAPLVGGFN 708
            ....|:.    :.|..||    ::|:|.|:|:..|....:.:..|  ||:::..:||:|.:
Mouse   423 VFGVPSV----IVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFL---- 479

  Fly   709 HFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNF 773
              ....::.|.:||::||.:|:||.|.||||       |....       .|..|:. .:.||..
Mouse   480 --KDGASEEETNLSKMVMKFWANFARNGNPN-------GGGLP-------HWPEYDQ-KEGYLKI 527

  Fly   774 DTKPKLKNHYRAHRLSFWLNL 794
            ....:.....:...:|||..|
Mouse   528 GASTQAAQRLKDKEVSFWAEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	176/666 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	38/96 (40%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	175/664 (26%)
		Aes	<121..>239	CDD:223730	47/162 (29%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740