Protein Alignment Nlg3 and Ces2a

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: NP_598721.1
• Gene: Ces2a / 102022
• MGIID: 2142491
• Length: 558
• Species: Mus musculus
• Alignment Length: 665
• Identity: 188/665 - (28%)
• Similarity: 281/665 - (42%)
• Gaps: 174/665 - (26%)

  Fly   154 SSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSP 218
            :|.|.||..|.:.|..|.:.... ..|.|:.|||:|.||||.|||.||.....||||:.......
Mouse    30 ASPIRNTHRGQVRGSFVHVKDTK-SGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPA 93

  Fly   219 VCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSGSSSSSS 283
            :|.|  |||.|...|.|         :..:||.: :.||||||||||.|
Mouse    94 MCLQ--PDIMNLEDAKE---------MNLILPPI-SMSEDCLYLNIYTP---------------- 130

  Fly   284 AGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQILV 348
                                  :.|..||  ..||:|::||......|.:..|.|.||:..:|::
Mouse   131 ----------------------THAQEGS--NLPVMVWIHGGGLVVGSASMNDVSKLAATEEIVI 171

  Fly   349 VTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACV 413
            |.|.||||||||.:.. |::::  .|:|.:|.:|||.|:::|||.|||:.:.:|:.|...|...|
Mouse   172 VAIQYRLGVLGFFSTG-DQHAR--GNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSV 233

  Fly   414 -HFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYA-AIVAHHVNCASDLPHAHLMKCLRE 476
             ..::|.|:  :| ||:.||:.||..|.| .|:|:.::.. ..||:...|.:....| |:.|||.
Mouse   234 SSHILSPMS--KG-LFHGAIMQSGVALLP-DLISDTSEVVYKTVANLSGCEATDSEA-LIHCLRA 293

  Fly   477 KTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGGEAGI- 540
            |:..::|::     ...|...|:    |:| |:::|..|       |...::...:.:....|:
Mouse   294 KSKQEILAI-----NQVFKMIPA----VVD-GEFLPKHP-------QELLTSMDFHPVPSIIGVN 341

  Fly   541 AAAGGWGTP---GQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNSGDVQYGIEADRRSRIL 602
            ....|||.|   | |::|:                ..:||                      ..|
Mouse   342 TDECGWGVPMFMG-LDHII----------------KNITR----------------------ETL 367

  Fly   603 KAYVRNTYT--------FHLNEIFATIVNEYT-DWERPVQHPINIRDETLEA-----LSDAQVVA 653
            .|.::||..        .||      :|.||. |.|.|         |||:|     |.|...|.
Mouse   368 PAVLKNTAARMMLPPECSHL------LVEEYMGDTEDP---------ETLQAQFREMLGDFMFVI 417

  Fly   654 PAAQTVDLHSADHRNSYLYVFDYQTRFGDY--PQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTK 716
            ||.|......: ....|.|.|.:.:.|..:  |......||:|:.::||:.|.    ....:.|:
Mouse   418 PALQVAHFQRS-QAPVYFYEFQHLSSFIKHVRPSHVKADHGDDVAFVFGSYLW----DMNLDLTE 477

  Fly   717 TEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKN 781
            .|..|..::|.||:||.|.||||.:              ....|...:. .::||..||:|.:..
Mouse   478 EEELLKRMMMKYWANFARNGNPNSE--------------GLPSWPVLDH-DEQYLQLDTQPAVGR 527

  Fly   782 HYRAHRLSFWLNLIP 796
            ..:|.||.||...:|
Mouse   528 ALKARRLQFWTKTLP 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	185/658 (28%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:395084	185/658 (28%)