Protein Alignment Nlg3 and nlgn2

DIOPT Version :10

• Sequence 1: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: XP_031755501.1
• Gene: nlgn2 / 100329187
• XenbaseID: XB-GENE-6034906
• Length: 810
• Species: Xenopus tropicalis
• Alignment Length: 932
• Identity: 295/932 - (31%)
• Similarity: 428/932 - (45%)
• Gaps: 209/932 - (22%)

  Fly   147 DQLPAQLSSRIINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVK 211
            |:.|      ::||..|.:.||...|:...|.||..|.|||||:||:|..||..|.:.|.|:.|:
 Frog    26 DKYP------VVNTNYGKLRGVKKDLNNEILGPVVQYLGIPYATPPIGERRFQAPEAPASWTEVR 84

  Fly   212 KADRFSPVCPQRLPDIHNETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSS 276
            .|..|:|||||.|   |.....: .:|....|.:..:..|:|||||||||||||||::.|....|
 Frog    85 NATTFAPVCPQNL---HGMLPGI-MLPLWFTENMDVVAGYVQNQSEDCLYLNIYVPLEDGPISKS 145

  Fly   277 GSSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLA 341
                            ......:..:.......||   |.||::|:||.||...:||.:||||||
 Frog   146 ----------------REDPRKAQHTPDEDIRDSG---KKPVMMFIHGGSYMEGTGNMFDGSVLA 191

  Fly   342 SYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGH 406
            :||.::|||:|||||:|||::.. |:.:|  .||||:|.|.||.||:|||..|||||..||:.|.
 Frog   192 AYGNVIVVTLNYRLGILGFMSTG-DQAAK--GNYGLLDQIQALRWLEENIGHFGGDPERITIFGS 253

  Fly   407 GTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLPHAHLM 471
            |.||:||..||.|.. .|| ||.:||..||:.::.||:...|.||..::|..|.|... .::.::
 Frog   254 GAGASCVSLLILSHH-SEG-LFQKAIAQSGTAISSWSVNYEPLKYTRLLAAKVGCDYQ-ENSEMV 315

  Fly   472 KCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLGG 536
            .|||.|....|:...|:|..:..||||.:|      ||.||..|.
 Frog   316 MCLRRKPYRDLVDQDIQPARYHIAFGPVVD------GDVVPDDPE-------------------- 354

  Fly   537 EAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAF-FSFNSGDVQYGIEADRRSR 600
                               :||.:   .:...||::.||.:.|.. |..::.:.:.||.......
 Frog   355 -------------------ILMEQ---GEFLNYDILMGVNQGEGLKFVEDTLESEDGISNSYFDF 397

  Fly   601 ILKAYVRNTYTFH-----LNEIFATIVNEYTDWERPVQHPINIRDETLEAL-SDAQVVAPAAQTV 659
            .:..:|.|.|.|.     |.|   ||...||||..  :...::|.:||.|| :|.|.||||..|.
 Frog   398 TVSNFVDNLYGFAEGKDVLRE---TIKFMYTDWAD--RDNGDMRRKTLLALFTDHQWVAPAIATA 457

  Fly   660 DLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEV 724
            ..|:......|.|.|.::.:....|:.....||:::||:||.|:||..:.|..|::|.::.||.|
 Frog   458 KFHAEYESPVYFYAFYHRCQAEGRPEWGEAAHGDEVPYVFGVPMVGATDLFPCNFSKNDVMLSAV 522

  Fly   725 VMFYWSNFVRTGNPNEQMETE----HGSRQERSRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRA 785
            ||.||:||.:||:||:.:..:    |   .:.:|::.:.||.:....|:||:...||::|::|||
 Frog   523 VMTYWTNFAKTGDPNQPVPQDTKFIH---TKPNRFEEVVWTKFNPKEKQYLHIGLKPRVKDNYRA 584

  Fly   786 HRLSFWLNLIPDLHKPGGDNVPAAHHQLHDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFT 850
            ::::|||.|:|.||:        .:..||            .|.....|...:|..::.:.....
 Frog   585 NKVAFWLELVPHLHE--------LNTGLH------------TSTTTRQPTGGTRRTSSGSTTRRP 629

  Fly   851 IFTNQVFSLLNLSSPSSSLQR---NGTRYGGGKIYPDDMMDGDHAGGAASASQDSDGFAAYSTAL 912
            ..|         ..|...::.   |..||..   :|.|..|                   |||.|
 Frog   630 PVT---------FPPDIDIEEEMDNRPRYSP---FPGDSRD-------------------YSTEL 663

  Fly   913 SVTIAIGCSLLILNVLIFAGVYYQRDKTRLSEPRPQTKLKRQENGQ--MPNNICG---------- 965
            |||:|:|.|||.||:|.||.:||:||:      |.:.:.:|...|:  :|.|...
 Frog   664 SVTVAVGASLLFLNILAFAALYYKRDR------RHELRQRRHSPGRGGVPGNDLAHHGPEEELMS 722

  Fly   966 ----------DLETLTIHAKSDPAT----ILSHHHAMQHHQLPPPEFADIPHRAPPPPKHMKSLQ 1016
                      |||.|..|....||.    .|:...|.:...||||         ||||.
 Frog   723 LQIKRAGGAPDLEPLRPHDILRPACPPDYTLALRRAPEDAPLPPP---------PPPPT------ 772

  Fly  1017 DPGGGGSVSGAVGVSGVVQMPP 1038
                  ||.....:||:..:.|
 Frog   773 ------SVMAPSTISGLPSLHP 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	225/647 (35%)
nlgn2	XP_031755501.1	COesterase	29..590	CDD:395084	226/651 (35%)