Protein Alignment Nlg3 and Nlgn4l

DIOPT Version :9

• Sequence 1: NP_001036685.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Sequence 2: XP_036018038.1
• Gene: Nlgn4l / 100113365
• MGIID: 3775191
• Length: 945
• Species: Mus musculus
• Alignment Length: 1023
• Identity: 324/1023 - (31%)
• Similarity: 452/1023 - (44%)
• Gaps: 253/1023 - (24%)

  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221
            ::.|..|.:.||...|.|..|.||..:.|:|||:||.|..||.||...:.|:||:.|.||:||||
Mouse    30 VVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCP 94

  Fly   222 QRLPDIHNETAAL-ERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSR----DSSGSSSS 281
            |.|    :|.|.| :|:|......|..:..|:|:|||||||||:|||.....:    |.:|:...
Mouse    95 QHL----DERALLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGGANGKKMADDVTGNDHG 155

  Fly   282 SSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYGQI 346
            ....|...|.||:::::               |:.||:|::||.||...:.|..|||||||||.:
Mouse   156 DDQDSRDPGVGGAAAAA---------------ARKPVMVYIHGGSYMEGTANIVDGSVLASYGDV 205

  Fly   347 LVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAA 411
            :|||:||||||||||:.. |:.:|  .||||:|.|.||.|::||..||||||:.:|:.|.|.||:
Mouse   206 IVVTVNYRLGVLGFLSTG-DQAAK--GNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGAS 267

  Fly   412 CVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVSNPAKYAAIVAHHVNCASDLP---------- 466
            ||..|..| ...|| ||.:||:.||:.|:.|::...||:||..:...|.||:..|
Mouse   268 CVSLLTLS-HYSEG-LFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGW 330

  Fly   467 -HAHLMKCLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQ------- 523
             .|.|:.|||.|...:|....:.|..:..||||::|      ||.:|..|.....|.:
Mouse   331 DSASLVSCLRGKAAGELARARVTPATYHVAFGPTVD------GDVIPDDPQILMEQGEFLNYDIM 389

  Fly   524 AQASTAAG----NGLGG--EAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFF 582
            ...:...|    :||||  :.|....|| |..|.:|:..:..       ...|..||...|..|.
Mouse   390 LGVNQGEGARFVDGLGGGHDGGYGGYGG-GYGGGVEDDEVQD-------GGPDGAAGGVSAGEFD 446

  Fly   583 SFNSGDVQ--YGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDW---ERPVQHPINIRDET 642
            ...||.:.  ||....|...:     |.|..|           .||||   :.|     ..|.:|
Mouse   447 LAVSGFINDLYGRPEGRGDAL-----RETVKF-----------MYTDWADRDSP-----EARRKT 490

  Fly   643 LEAL-SDAQVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGD----------------------YP 684
            |.|| :|.|.||||..|.|||:.....:|.|.|.::...|.                      .|
Mouse   491 LVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHRCHGGGGGGGGVDGVAGGVAGGVGGEEARP 555

  Fly   685 QRQGCIHGEDLPYIFGAPLVGGFNHFTRNYTKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSR 749
            ......||:::||:||.|:.|..:.|..|:::.::.||.|||.||:||.:||:||:.:..:....
Mouse   556 AWADAAHGDEVPYVFGVPMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPNQPVAQDTRFV 620

  Fly   750 QER-SRYKTIEWTAYESVHKKYLNFDTKPKLKNHYRAHRLSFWLNLIPDLHKPGGDNVPAAHHQL 813
            ..| :|::.:.|..|:...:.||:...:|::::||||.:::|||.|:|.||....|  |.|
Mouse   621 HTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLHGLAAD--PGA---- 679

  Fly   814 HDDDDEDNNIPSDASVKPLNPPYISRAANAAAMANFTIFTNQVFSLLNLSSPSSSLQRNGTRYGG 878
                                  |:|.||..||                   ||....|:....||
Mouse   680 ----------------------YLSAAATRAA-------------------PSGDPDRDPGGGGG 703

  Fly   879 GKIYPDD-------MMDGDHAGGAASASQDSDGFAA----------------YSTALSVTIAIGC 920
            |:..|..       |.....|.|:...|....|..:                |||.||||||:|.
Mouse   704 GRRRPRPATRRPAVMTSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAVGA 768

  Fly   921 SLLILNVLIFAGVYYQRDKTRLS----------------------EPRPQTKLKRQENGQMPNNI 963
            |||.||||.||.:||::||.|..                      .|||......:..|:
Mouse   769 SLLFLNVLAFAALYYKKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAGRRGGE----- 828

  Fly   964 CGDLETLTIHAKSDPATILSHH-----------HAMQHHQLP-PPEFA--------DIPHRAPPP 1008
            ||  ..:|..|....|..|.|.           ..:...:|. ||::|        |:| ||...
Mouse   829 CG--AVVTAMAAEASAGGLGHDGVGGVGVGGVIGGVAGLRLACPPDYALTLRRSPDDVP-RAGAG 890

  Fly  1009 PKHMKSLQDP---GGGGSVSG------AVGVSGVV-----QMPP--PH 1040
            |..|..:...   ||||:|.|      .|||:||.     |..|  ||
Mouse   891 PGAMTLIPGALGGGGGGAVHGFNTFGSGVGVAGVAGVATSQAGPGLPH 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	236/691 (34%)
		Aes	<313..>410	CDD:223730	53/96 (55%)
Nlgn4l	XP_036018038.1	COesterase	30..663	CDD:395084	236/691 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	360	1.000	Domainoid score	I955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.150